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GO:0006285 base-excision repair, AP site formation

The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired.

Term Information

ID GO:0006285
Name base-excision repair, AP site formation
Ontology Biological Process
Definition The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired.
Comment

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Ancestor Chart

Visual display of a section of the GO directed acyclic graph (DAG) for a single GO term. Terms in the GO are linked to parent (more general) terms and often to child (more specific) terms by one or more 'relationships'

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Chart

Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0008150 biological_process
GO:0050896 response to stimulus
GO:0009987 cellular process
GO:0008152 metabolic process
GO:0044238 primary metabolic process
GO:0006807 nitrogen compound metabolic process
GO:0009056 catabolic process
GO:0006950 response to stress
GO:0043170 macromolecule metabolic process
GO:0044237 cellular metabolic process
GO:0043283 biopolymer metabolic process
GO:0006974 response to DNA damage stimulus
GO:0051716 cellular response to stimulus
GO:0009057 macromolecule catabolic process
GO:0044248 cellular catabolic process
GO:0033554 cellular response to stress
GO:0044260 cellular macromolecule metabolic process
GO:0043285 biopolymer catabolic process
GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO:0034984 cellular response to DNA damage stimulus
GO:0034960 cellular biopolymer metabolic process
GO:0044265 cellular macromolecule catabolic process
GO:0006259 DNA metabolic process
GO:0034962 cellular biopolymer catabolic process
GO:0006281 DNA repair
GO:0006308 DNA catabolic process
GO:0006284 base-excision repair
GO:0006285 base-excision repair, AP site formation

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
I GO:0045007 depurination
I GO:0045008 depyrimidination

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

This display shows those GO terms which have been annotated to the same proteins as this term.
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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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17ms
Stand-alone
Hostnametomcat-8.ebi.ac.uk
Uptime17:46 13/10/2009
Data version2009-11-27-04-02-36
Terminal
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