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GO:0006273 lagging strand elongation

The synthesis of DNA from a template strand in a net 3' to 5' direction. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork.

Term Information

ID GO:0006273
Name lagging strand elongation
Ontology Biological Process
Definition The synthesis of DNA from a template strand in a net 3' to 5' direction. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork.
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Ancestor Chart

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Chart

Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0008152 metabolic process
GO:0009058 biosynthetic process
GO:0006807 nitrogen compound metabolic process
GO:0043170 macromolecule metabolic process
GO:0044238 primary metabolic process
GO:0044237 cellular metabolic process
GO:0043283 biopolymer metabolic process
GO:0009059 macromolecule biosynthetic process
GO:0044260 cellular macromolecule metabolic process
GO:0044249 cellular biosynthetic process
GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO:0043284 biopolymer biosynthetic process
GO:0034960 cellular biopolymer metabolic process
GO:0034645 cellular macromolecule biosynthetic process
GO:0006259 DNA metabolic process
GO:0022616 DNA strand elongation
GO:0034961 cellular biopolymer biosynthetic process
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006271 DNA strand elongation during DNA replication
GO:0006273 lagging strand elongation

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
P GO:0033567 DNA replication, Okazaki fragment processing

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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12ms
Stand-alone
Hostnametomcat-7.ebi.ac.uk
Uptime16:38 12/10/2009
Data version2009-11-24-04-03-40
Terminal
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