spacer

GO:0006127 glycerophosphate shuttle

Term Information

ID GO:0006127
Name glycerophosphate shuttle
Ontology Biological Process
Definition The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle.
PMID:16368075
GONUTS GO:0006127 Wiki Page

Cross-Ontology Relations

Relation Other Ontology ID Term
has_input CHEBI CHEBI:16908 NADH
has_output CHEBI CHEBI:15846 NAD(+)
has_participant CHEBI CHEBI:16108 glycerone phosphate
has_participant CHEBI CHEBI:57597 sn-glycerol 3-phosphate(2-)

Cross-references

Database ID
MetaCyc PWY-6118

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006127:
Relationship To GO:0006127 Child Term Child Term Name
Has part GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity
Has part GO:0052590 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0006127. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0006127 based on the entire annotation set Co-occurrence statistics for GO:0006127 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2015-08-09 Added RELATION is a GO:0006116 (NADH oxidation)
2015-08-09 Deleted RELATION is a GO:0006839 (mitochondrial transport)
2015-08-09 Added RELATION is a GO:1901135 (carbohydrate derivative metabolic process)
2015-08-09 Added RELATION is a GO:0042180 (cellular ketone metabolic process)
2015-08-09 Added XREF MetaCyc:PWY-6118
2008-05-13 Added DEFINITION The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle.
2008-05-12 Deleted DEFINITION The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle.
2008-04-01 Updated RELATION is a GO:0006839 (mitochondrial transport)
2008-04-01 Updated RELATION part of GO:0022904 (respiratory electron transport chain)
2005-09-02 Added DEFINITION The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle.
2002-02-06 Updated TERM glycerophosphate shuttle
2001-04-03 Updated TERM glycerophosphate shuttle
2001-03-30 Added TERM glycerophosphate shuttle

Term

Timestamp Action Category Detail
2002-02-06 Updated TERM glycerophosphate shuttle
2001-04-03 Updated TERM glycerophosphate shuttle
2001-03-30 Added TERM glycerophosphate shuttle

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle.
2008-05-12 Deleted DEFINITION The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle.
2005-09-02 Added DEFINITION The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle.

Relationships

Timestamp Action Category Detail
2015-08-09 Added RELATION is a GO:0006116 (NADH oxidation)
2015-08-09 Deleted RELATION is a GO:0006839 (mitochondrial transport)
2015-08-09 Added RELATION is a GO:1901135 (carbohydrate derivative metabolic process)
2015-08-09 Added RELATION is a GO:0042180 (cellular ketone metabolic process)
2008-04-01 Updated RELATION is a GO:0006839 (mitochondrial transport)
2008-04-01 Updated RELATION part of GO:0022904 (respiratory electron transport chain)

Cross-references

Timestamp Action Category Detail
2015-08-09 Added XREF MetaCyc:PWY-6118
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
13ms