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GO:0006099 tricarboxylic acid cycle

Term Information

ID GO:0006099
Name tricarboxylic acid cycle
Ontology Biological Process
Definition A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
GONUTS GO:0006099 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact Krebs cycle
exact TCA cycle
exact citric acid cycle

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:30769 citric acid

Cross-references

Database ID
InterPro IPR004224
InterPro IPR004406
InterPro IPR004434
InterPro IPR004436
InterPro IPR004439
InterPro IPR004489
InterPro IPR006231
InterPro IPR006248
InterPro IPR006255
InterPro IPR007566
InterPro IPR011281
InterPro IPR011603
InterPro IPR014273
InterPro IPR014312
InterPro IPR014314
InterPro IPR015929
InterPro IPR015933
InterPro IPR018129
InterPro IPR018495
InterPro IPR018951
InterPro IPR019810
InterPro IPR021135
InterPro IPR022805
InterPro IPR023958
MetaCyc P105-PWY
MetaCyc P42-PWY
MetaCyc TCA
UniProtKB-KW Tricarboxylic acid cycle
Wikipedia Tricarboxylic_acid_cycle

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0006100 tricarboxylic acid cycle intermediate metabolic process CONSIDER GO:0006099

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006099:
Relationship To GO:0006099 Child Term Child Term Name
Is a GO:0019643 reductive tricarboxylic acid cycle

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO ID
Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0006099. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0006099 based on the entire annotation set Co-occurrence statistics for GO:0006099 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-12-04 Added RELATION is a GO:0006101 (citrate metabolic process)
2013-01-24 Added RELATION is a GO:0044238 (primary metabolic process)
2013-01-24 Deleted RELATION is a GO:0046356 (acetyl-CoA catabolic process)
2009-05-21 Deleted XREF MetaCyc:P82-PWY
2009-05-21 Deleted XREF MetaCyc:P63-PWY
2009-05-21 Deleted XREF MetaCyc:P62-PWY
2009-05-21 Deleted XREF MetaCyc:P104-PWY
2009-05-21 Deleted XREF MetaCyc:P103-PWY
2009-05-21 Deleted XREF MetaCyc:P102-PWY
2009-03-02 Added XREF Wikipedia:Tricarboxylic_acid_cycle
2008-05-13 Added DEFINITION A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
2008-05-12 Deleted DEFINITION A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
2008-04-27 Updated DEFINITION A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
2008-04-01 Updated RELATION is a GO:0046356 (acetyl-CoA catabolic process)
2008-04-01 Updated RELATION part of GO:0009060 (aerobic respiration)
2007-08-09 Added SYNONYM Krebs cycle
2007-08-09 Added SYNONYM TCA cycle
2007-08-09 Added SYNONYM citric acid cycle
2007-08-09 Deleted SYNONYM Krebs cycle
2007-08-09 Deleted SYNONYM TCA cycle
2007-08-09 Deleted SYNONYM citric acid cycle
2004-07-08 Added SYNONYM TCA cycle
2004-07-04 Deleted SYNONYM TCA cycle
2004-07-02 Added SYNONYM TCA cycle
2004-07-01 Added DEFINITION A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two C02 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
2004-04-19 Added SYNONYM Krebs cycle
2004-04-19 Added SYNONYM citric acid cycle
2004-04-16 Deleted SYNONYM Krebs cycle
2004-04-16 Deleted SYNONYM citric acid cycle
2003-10-27 Added SYNONYM Krebs cycle
2003-10-27 Added SYNONYM citric acid cycle
2003-10-27 Added XREF MetaCyc:TCA
2003-10-27 Added XREF MetaCyc:P82-PWY
2003-10-27 Added XREF MetaCyc:P63-PWY
2003-10-27 Added XREF MetaCyc:P62-PWY
2003-10-27 Added XREF MetaCyc:P42-PWY
2003-10-27 Added XREF MetaCyc:P105-PWY
2003-10-27 Added XREF MetaCyc:P104-PWY
2003-10-27 Added XREF MetaCyc:P103-PWY
2003-10-27 Added XREF MetaCyc:P102-PWY
2003-03-19 Deleted SYNONYM Krebs cycle
2003-03-19 Deleted SYNONYM citric acid cycle
2002-02-06 Updated TERM tricarboxylic acid cycle
2001-04-03 Updated TERM tricarboxylic acid cycle
2001-03-30 Added SYNONYM Krebs cycle
2001-03-30 Added SYNONYM citric acid cycle
2001-03-30 Added TERM tricarboxylic acid cycle

Term

Timestamp Action Category Detail
2002-02-06 Updated TERM tricarboxylic acid cycle
2001-04-03 Updated TERM tricarboxylic acid cycle
2001-03-30 Added TERM tricarboxylic acid cycle

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
2008-05-12 Deleted DEFINITION A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
2008-04-27 Updated DEFINITION A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
2007-08-09 Added SYNONYM Krebs cycle
2007-08-09 Added SYNONYM TCA cycle
2007-08-09 Added SYNONYM citric acid cycle
2007-08-09 Deleted SYNONYM Krebs cycle
2007-08-09 Deleted SYNONYM TCA cycle
2007-08-09 Deleted SYNONYM citric acid cycle
2004-07-08 Added SYNONYM TCA cycle
2004-07-04 Deleted SYNONYM TCA cycle
2004-07-02 Added SYNONYM TCA cycle
2004-07-01 Added DEFINITION A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two C02 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
2004-04-19 Added SYNONYM Krebs cycle
2004-04-19 Added SYNONYM citric acid cycle
2004-04-16 Deleted SYNONYM Krebs cycle
2004-04-16 Deleted SYNONYM citric acid cycle
2003-10-27 Added SYNONYM Krebs cycle
2003-10-27 Added SYNONYM citric acid cycle
2003-03-19 Deleted SYNONYM Krebs cycle
2003-03-19 Deleted SYNONYM citric acid cycle
2001-03-30 Added SYNONYM Krebs cycle
2001-03-30 Added SYNONYM citric acid cycle

Relationships

Timestamp Action Category Detail
2014-12-04 Added RELATION is a GO:0006101 (citrate metabolic process)
2013-01-24 Added RELATION is a GO:0044238 (primary metabolic process)
2013-01-24 Deleted RELATION is a GO:0046356 (acetyl-CoA catabolic process)
2008-04-01 Updated RELATION is a GO:0046356 (acetyl-CoA catabolic process)
2008-04-01 Updated RELATION part of GO:0009060 (aerobic respiration)

Cross-references

Timestamp Action Category Detail
2009-05-21 Deleted XREF MetaCyc:P82-PWY
2009-05-21 Deleted XREF MetaCyc:P63-PWY
2009-05-21 Deleted XREF MetaCyc:P62-PWY
2009-05-21 Deleted XREF MetaCyc:P104-PWY
2009-05-21 Deleted XREF MetaCyc:P103-PWY
2009-05-21 Deleted XREF MetaCyc:P102-PWY
2009-03-02 Added XREF Wikipedia:Tricarboxylic_acid_cycle
2003-10-27 Added XREF MetaCyc:TCA
2003-10-27 Added XREF MetaCyc:P82-PWY
2003-10-27 Added XREF MetaCyc:P63-PWY
2003-10-27 Added XREF MetaCyc:P62-PWY
2003-10-27 Added XREF MetaCyc:P42-PWY
2003-10-27 Added XREF MetaCyc:P105-PWY
2003-10-27 Added XREF MetaCyc:P104-PWY
2003-10-27 Added XREF MetaCyc:P103-PWY
2003-10-27 Added XREF MetaCyc:P102-PWY
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