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GO:0006099 tricarboxylic acid cycleA nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
Term Information
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| Type | Synonym |
| exact | citric acid cycle |
| exact | TCA cycle |
| exact | Krebs cycle |
| Database | ID |
| INTERPRO | IPR004439 |
| INTERPRO | IPR004489 |
| INTERPRO | IPR001449 |
| INTERPRO | IPR018951 |
| INTERPRO | IPR018495 |
| INTERPRO | IPR007566 |
| INTERPRO | IPR015929 |
| INTERPRO | IPR015933 |
| MetaCyc | P105-PWY |
| MetaCyc | P42-PWY |
| MetaCyc | TCA |
| Wikipedia | Tricarboxylic_acid_cycle |
| INTERPRO | IPR004224 |
| INTERPRO | IPR019810 |
| INTERPRO | IPR006255 |
| INTERPRO | IPR015930 |
| INTERPRO | IPR006231 |
| INTERPRO | IPR006248 |
| INTERPRO | IPR014273 |
| INTERPRO | IPR018129 |
| INTERPRO | IPR007992 |
| INTERPRO | IPR011281 |
| INTERPRO | IPR000701 |
| INTERPRO | IPR004406 |
| INTERPRO | IPR004434 |
| INTERPRO | IPR004436 |
GO:0006100 tricarboxylic acid cycle intermediate metabolic process |
(consider GO:0006099) |
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0008150 biological_process | ||||||||||||||||
![]() | GO:0009987 cellular process | |||||||||||||||
![]() | ![]() | GO:0008152 metabolic process | ||||||||||||||
![]() | ![]() | ![]() | GO:0009056 catabolic process | |||||||||||||
![]() | ![]() | ![]() | ![]() | GO:0044237 cellular metabolic process | ||||||||||||
![]() | ![]() | ![]() | ![]() | ![]() | GO:0006091 generation of precursor metabolites and energy | |||||||||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0051186 cofactor metabolic process | ||||||||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0044248 cellular catabolic process | |||||||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0015980 energy derivation by oxidation of organic compounds | ||||||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0006732 coenzyme metabolic process | |||||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0045333 cellular respiration | ||||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0006084 acetyl-CoA metabolic process | |||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0009060 aerobic respiration | ||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0051187 cofactor catabolic process | |||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0009109 coenzyme catabolic process | ||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0046356 acetyl-CoA catabolic process | |
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0006099 tricarboxylic acid cycle |
| Code | Relationship |
![]() | part of |
![]() | is a |
![]() | regulates |
![]() | +ve regulates |
![]() | -ve regulates |
| I | GO:0019643 reductive tricarboxylic acid cycle |
| Code | Relationship |
| P | part of |
| I | is a |
| Hostname | tomcat-7.ebi.ac.uk |
| Uptime | 16:38 12/10/2009 |
| Data version | 2009-11-20-04-03-08 |