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GO:0006099 tricarboxylic acid cycle

A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

Term Information

ID GO:0006099
Name tricarboxylic acid cycle
Ontology Biological Process
Definition A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
Comment

Synonyms

Type Synonym
exact citric acid cycle
exact TCA cycle
exact Krebs cycle

Cross-references associated with this term:

Database ID
INTERPRO IPR004439
INTERPRO IPR004489
INTERPRO IPR001449
INTERPRO IPR018951
INTERPRO IPR018495
INTERPRO IPR007566
INTERPRO IPR015929
INTERPRO IPR015933
MetaCyc P105-PWY
MetaCyc P42-PWY
MetaCyc TCA
Wikipedia Tricarboxylic_acid_cycle
INTERPRO IPR004224
INTERPRO IPR019810
INTERPRO IPR006255
INTERPRO IPR015930
INTERPRO IPR006231
INTERPRO IPR006248
INTERPRO IPR014273
INTERPRO IPR018129
INTERPRO IPR007992
INTERPRO IPR011281
INTERPRO IPR000701
INTERPRO IPR004406
INTERPRO IPR004434
INTERPRO IPR004436

This term can be used instead of these obsolete terms:

GO:0006100 tricarboxylic acid cycle intermediate metabolic process (consider GO:0006099)

Web service: term information

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Ancestor Chart

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Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0008152 metabolic process
GO:0009056 catabolic process
GO:0044237 cellular metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0051186 cofactor metabolic process
GO:0044248 cellular catabolic process
GO:0015980 energy derivation by oxidation of organic compounds
GO:0006732 coenzyme metabolic process
GO:0045333 cellular respiration
GO:0006084 acetyl-CoA metabolic process
GO:0009060 aerobic respiration
GO:0051187 cofactor catabolic process
GO:0009109 coenzyme catabolic process
GO:0046356 acetyl-CoA catabolic process
GO:0006099 tricarboxylic acid cycle

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
I GO:0019643 reductive tricarboxylic acid cycle

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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