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GO:0005967 mitochondrial pyruvate dehydrogenase complex

Term Information

ID GO:0005967
Name mitochondrial pyruvate dehydrogenase complex
Ontology Cellular Component
Definition Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
Comment Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'.
GONUTS GO:0005967 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
broad pyruvate dehydrogenase complex (lipoamide)

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000057 GO:0005623 cell only_in_taxon 131567 cellular organisms
GOTAX:0000060 GO:0005739 mitochondrion only_in_taxon 2759 Eukaryota
More information on taxon constraints in GO is available here

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005967:
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Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0005967. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0005967 based on the entire annotation set Co-occurrence statistics for GO:0005967 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2015-06-25 Deleted RELATION is a GO:0044429 (mitochondrial part)
2015-05-11 Added RELATION is a GO:0098798 (mitochondrial protein complex)
2015-04-24 Added RELATION part of GO:0005739 (mitochondrion)
2013-02-02 Deleted RELATION part of GO:0005739 (mitochondrion)
2012-10-29 Added RELATION part of GO:0005739 (mitochondrion)
2009-07-11 Added SYNONYM pyruvate dehydrogenase complex (lipoamide)
2009-07-11 Deleted SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Eukaryota)
2009-07-11 Deleted SYNONYM pyruvate dehydrogenase complex (sensu Eukaryota)
2009-07-11 Added DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
2009-07-11 Deleted DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
2008-05-13 Added DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
2008-05-12 Deleted DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
2008-04-01 Updated RELATION is a GO:0045254 (pyruvate dehydrogenase complex)
2008-04-01 Updated RELATION part of GO:0005759 (mitochondrial matrix)
2008-04-01 Updated RELATION is a GO:0044429 (mitochondrial part)
2007-08-09 Added SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Eukaryota)
2007-08-09 Added SYNONYM pyruvate dehydrogenase complex (sensu Eukaryota)
2007-08-09 Deleted SYNONYM pyruvate dehydrogenase complex (sensu Eukaryota)
2007-08-09 Deleted SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Eukaryota)
2007-02-16 Updated DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
2007-02-12 Added SYNONYM pyruvate dehydrogenase complex (sensu Eukaryota)
2007-02-12 Updated TERM mitochondrial pyruvate dehydrogenase complex
2007-01-18 Deleted SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu the Eukaryota research community)
2007-01-18 Added SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Eukaryota)
2007-01-18 Updated TERM pyruvate dehydrogenase complex (sensu Eukaryota)
2007-01-15 Updated TERM pyruvate dehydrogenase complex (sensu the Eukaryota research community)
2007-01-15 Added SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu the Eukaryota research community)
2007-01-15 Deleted SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Eukaryota)
2004-09-19 Added SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Eukaryota)
2004-09-19 Deleted SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Eukarya)
2004-09-19 Updated TERM pyruvate dehydrogenase complex (sensu Eukaryota)
2004-07-09 Updated DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759).
2004-04-19 Added SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Eukarya)
2004-04-16 Deleted SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Eukarya)
2003-04-18 Added SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Eukarya)
2003-04-18 Added DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
2002-05-10 Updated TERM pyruvate dehydrogenase complex (sensu Eukarya)
2002-02-06 Updated TERM pyruvate dehydrogenase complex
2001-04-03 Updated TERM pyruvate dehydrogenase complex
2001-03-30 Added TERM pyruvate dehydrogenase complex

Term

Timestamp Action Category Detail
2007-02-12 Updated TERM mitochondrial pyruvate dehydrogenase complex
2007-01-18 Updated TERM pyruvate dehydrogenase complex (sensu Eukaryota)
2007-01-15 Updated TERM pyruvate dehydrogenase complex (sensu the Eukaryota research community)
2004-09-19 Updated TERM pyruvate dehydrogenase complex (sensu Eukaryota)
2002-05-10 Updated TERM pyruvate dehydrogenase complex (sensu Eukarya)
2002-02-06 Updated TERM pyruvate dehydrogenase complex
2001-04-03 Updated TERM pyruvate dehydrogenase complex
2001-03-30 Added TERM pyruvate dehydrogenase complex

Definition/synonyms

Timestamp Action Category Detail
2009-07-11 Added SYNONYM pyruvate dehydrogenase complex (lipoamide)
2009-07-11 Deleted SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Eukaryota)
2009-07-11 Deleted SYNONYM pyruvate dehydrogenase complex (sensu Eukaryota)
2009-07-11 Added DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
2009-07-11 Deleted DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
2008-05-13 Added DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
2008-05-12 Deleted DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
2007-08-09 Added SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Eukaryota)
2007-08-09 Added SYNONYM pyruvate dehydrogenase complex (sensu Eukaryota)
2007-08-09 Deleted SYNONYM pyruvate dehydrogenase complex (sensu Eukaryota)
2007-08-09 Deleted SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Eukaryota)
2007-02-16 Updated DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
2007-02-12 Added SYNONYM pyruvate dehydrogenase complex (sensu Eukaryota)
2007-01-18 Deleted SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu the Eukaryota research community)
2007-01-18 Added SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Eukaryota)
2007-01-15 Added SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu the Eukaryota research community)
2007-01-15 Deleted SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Eukaryota)
2004-09-19 Added SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Eukaryota)
2004-09-19 Deleted SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Eukarya)
2004-07-09 Updated DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759).
2004-04-19 Added SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Eukarya)
2004-04-16 Deleted SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Eukarya)
2003-04-18 Added SYNONYM pyruvate dehydrogenase complex (lipoamide) (sensu Eukarya)
2003-04-18 Added DEFINITION Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.

Relationships

Timestamp Action Category Detail
2015-06-25 Deleted RELATION is a GO:0044429 (mitochondrial part)
2015-05-11 Added RELATION is a GO:0098798 (mitochondrial protein complex)
2015-04-24 Added RELATION part of GO:0005739 (mitochondrion)
2013-02-02 Deleted RELATION part of GO:0005739 (mitochondrion)
2012-10-29 Added RELATION part of GO:0005739 (mitochondrion)
2008-04-01 Updated RELATION is a GO:0045254 (pyruvate dehydrogenase complex)
2008-04-01 Updated RELATION part of GO:0005759 (mitochondrial matrix)
2008-04-01 Updated RELATION is a GO:0044429 (mitochondrial part)
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