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GO:0005944 phosphatidylinositol 3-kinase complex, class IB

Term Information

ID GO:0005944
Name phosphatidylinositol 3-kinase complex, class IB
Ontology Cellular Component
Definition A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IB phosphoinositide 3-kinase (PI3K) subunit and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks.
PMID:9255069 PMID:9759495
Secondary IDs GO:0035031
GONUTS GO:0005944 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
exact phosphoinositide 3-kinase complex, class IB
related 1-phosphatidylinositol-4-phosphate kinase, class IB complex
exact class IB PI3K complex

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0097651 phosphatidylinositol 3-kinase complex, class I never_in_taxon 4932 Saccharomyces cerevisiae
More information on taxon constraints in GO is available here

Cross-references

Database ID
InterPro IPR019522

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005944:
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Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0005944. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0005944 based on the entire annotation set Co-occurrence statistics for GO:0005944 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2015-06-18 Added RELATION capable of GO:0035005 (1-phosphatidylinositol-4-phosphate 3-kinase activity)
2014-09-18 Deleted DEFINITION A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IB phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks.
2014-09-18 Added DEFINITION A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IB phosphoinositide 3-kinase (PI3K) subunit and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks.
2014-09-18 Updated TERM phosphatidylinositol 3-kinase complex, class IB
2014-09-18 Added RELATION is a GO:0097651 (phosphatidylinositol 3-kinase complex, class I)
2014-09-18 Deleted RELATION is a GO:0005942 (phosphatidylinositol 3-kinase complex)
2014-09-18 Added SYNONYM 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
2008-05-13 Added DEFINITION A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IB phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks.
2008-05-12 Deleted DEFINITION A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IB phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks.
2008-04-01 Updated RELATION is a GO:0005942 (phosphatidylinositol 3-kinase complex)
2008-03-11 Updated DEFINITION A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IB phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks.
2008-02-24 Added SECONDARY GO:0035031 (phosphoinositide 3-kinase complex, class IB)
2008-02-24 Added SYNONYM 1-phosphatidylinositol-4-phosphate kinase, class IB complex
2008-02-24 Added SYNONYM class IB PI3K complex
2008-02-24 Added SYNONYM phosphoinositide 3-kinase complex, class IB
2008-02-24 Updated TERM 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
2007-05-27 Added DEFINITION A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic subunit of 110-120 kDa and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes.
2002-05-24 Updated TERM 1-phosphatidylinositol-4-phosphate kinase, class IB complex
2002-02-06 Updated TERM 1-phosphatidylinositol-4-phosphate kinase, class IB
2001-04-03 Updated TERM 1-phosphatidylinositol-4-phosphate kinase, class IB
2001-03-30 Added TERM 1-phosphatidylinositol-4-phosphate kinase, class IB

Term

Timestamp Action Category Detail
2014-09-18 Updated TERM phosphatidylinositol 3-kinase complex, class IB
2008-02-24 Updated TERM 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
2002-05-24 Updated TERM 1-phosphatidylinositol-4-phosphate kinase, class IB complex
2002-02-06 Updated TERM 1-phosphatidylinositol-4-phosphate kinase, class IB
2001-04-03 Updated TERM 1-phosphatidylinositol-4-phosphate kinase, class IB
2001-03-30 Added TERM 1-phosphatidylinositol-4-phosphate kinase, class IB

Definition/synonyms

Timestamp Action Category Detail
2014-09-18 Deleted DEFINITION A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IB phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks.
2014-09-18 Added DEFINITION A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IB phosphoinositide 3-kinase (PI3K) subunit and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks.
2014-09-18 Added SYNONYM 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
2008-05-13 Added DEFINITION A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IB phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks.
2008-05-12 Deleted DEFINITION A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IB phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks.
2008-03-11 Updated DEFINITION A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IB phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks.
2008-02-24 Added SYNONYM 1-phosphatidylinositol-4-phosphate kinase, class IB complex
2008-02-24 Added SYNONYM class IB PI3K complex
2008-02-24 Added SYNONYM phosphoinositide 3-kinase complex, class IB
2007-05-27 Added DEFINITION A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic subunit of 110-120 kDa and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes.

Relationships

Timestamp Action Category Detail
2015-06-18 Added RELATION capable of GO:0035005 (1-phosphatidylinositol-4-phosphate 3-kinase activity)
2014-09-18 Added RELATION is a GO:0097651 (phosphatidylinositol 3-kinase complex, class I)
2014-09-18 Deleted RELATION is a GO:0005942 (phosphatidylinositol 3-kinase complex)
2008-04-01 Updated RELATION is a GO:0005942 (phosphatidylinositol 3-kinase complex)

Other

Timestamp Action Category Detail
2008-02-24 Added SECONDARY GO:0035031 (phosphoinositide 3-kinase complex, class IB)
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