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GO:0005943 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complexA heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IA phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways.
Term Information
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| Type | Synonym |
| exact | 1-phosphatidylinositol-4-phosphate kinase, class IA complex |
| exact | phosphoinositide 3-kinase complex, class IA |
| exact | class IA PI3K complex |
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0005575 cellular_component | ||||||||||||
![]() | GO:0032991 macromolecular complex | |||||||||||
![]() | ![]() | GO:0005623 cell | ||||||||||
![]() | ![]() | ![]() | GO:0044464 cell part | |||||||||
![]() | ![]() | ![]() | ![]() | GO:0043234 protein complex | ||||||||
![]() | ![]() | ![]() | ![]() | ![]() | GO:0005622 intracellular | |||||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0044424 intracellular part | ||||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0005737 cytoplasm | |||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0044444 cytoplasmic part | ||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0005829 cytosol | |||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0044445 cytosolic part | ||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0005942 phosphoinositide 3-kinase complex | |
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0005943 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex |
| Code | Relationship |
![]() | part of |
![]() | is a |
![]() | regulates |
![]() | +ve regulates |
![]() | -ve regulates |
| Hostname | tomcat-7.ebi.ac.uk |
| Uptime | 16:38 12/10/2009 |
| Data version | 2009-11-23-04-03-36 |