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GO:0005942 phosphatidylinositol 3-kinase complex

Term Information

ID GO:0005942
Name phosphatidylinositol 3-kinase complex
Ontology Cellular Component
Definition A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
PMID:24587488
Comment For discussion of membrane association, please see https://sourceforge.net/p/geneontology/ontology-requests/11559/
GONUTS GO:0005942 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow PIK3CA-PIK3R1 complex
exact phosphoinositide 3-kinase complex
narrow PIK3C3-PIK3R4 complex
narrow PI3-kinase p85-subunit alpha- PI3-kinase p110 complex
exact PI3K complex
exact 1-phosphatidylinositol 3-kinase complex

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_pir462

Cross-references

Database ID
InterPro IPR001720

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005942:
Relationship To GO:0005942 Child Term Child Term Name
Is a GO:0035032 phosphatidylinositol 3-kinase complex, class III
Is a GO:0097651 phosphatidylinositol 3-kinase complex, class I
Is a GO:0097652 phosphatidylinositol 3-kinase complex, class II

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0005942. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0005942 based on the entire annotation set Co-occurrence statistics for GO:0005942 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2015-03-19 Added RELATION is a GO:0044425 (membrane part)
2015-03-18 Added RELATION part of GO:0019898 (extrinsic component of membrane)
2015-03-18 Deleted RELATION is a GO:0044445 (cytosolic part)
2014-09-18 Added DEFINITION A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
2014-09-18 Deleted DEFINITION A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphatidylinositol 3-kinase (PI3K).
2013-11-28 Added RELATION is a GO:1990234 (transferase complex)
2013-11-28 Deleted RELATION is a GO:1902494 (catalytic complex)
2013-11-15 Added RELATION is a GO:1902494 (catalytic complex)
2013-11-15 Deleted RELATION is a GO:0043234 (protein complex)
2013-04-18 Updated SLIM goslim_pir
2011-01-30 Updated TERM phosphatidylinositol 3-kinase complex
2011-01-30 Deleted DEFINITION A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K).
2011-01-30 Added DEFINITION A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphatidylinositol 3-kinase (PI3K).
2011-01-30 Deleted SYNONYM phosphatidylinositol 3-kinase complex
2011-01-30 Added SYNONYM phosphoinositide 3-kinase complex
2009-02-28 Added SYNONYM PI3-kinase p85-subunit alpha- PI3-kinase p110 complex
2009-02-28 Added SYNONYM PIK3CA-PIK3R1 complex
2009-02-16 Added SYNONYM PIK3C3-PIK3R4 complex
2009-02-16 Added SYNONYM phosphatidylinositol 3-kinase complex
2008-06-09 Added SLIM goslim_pir
2008-05-13 Added DEFINITION A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K).
2008-05-12 Deleted DEFINITION A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K).
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0044445 (cytosolic part)
2007-08-09 Added SYNONYM 1-phosphatidylinositol 3-kinase complex
2007-08-09 Added SYNONYM PI3K complex
2007-08-09 Deleted SYNONYM 1-phosphatidylinositol 3-kinase complex
2007-08-09 Deleted SYNONYM PI3K complex
2004-04-19 Added SYNONYM 1-phosphatidylinositol 3-kinase complex
2004-04-19 Added SYNONYM PI3K complex
2004-04-16 Deleted SYNONYM PI3K complex
2004-04-16 Deleted SYNONYM 1-phosphatidylinositol 3-kinase complex
2003-10-07 Deleted SYNONYM class III PI3K
2003-10-07 Added SYNONYM 1-phosphatidylinositol 3-kinase complex
2003-10-07 Added SYNONYM PI3K complex
2003-10-07 Added DEFINITION A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K).
2003-10-07 Updated TERM phosphoinositide 3-kinase complex
2002-05-24 Updated TERM 1-phosphatidylinositol 3-kinase complex
2002-02-06 Updated TERM 1-phosphatidylinositol 3-kinase
2001-04-03 Updated TERM 1-phosphatidylinositol 3-kinase
2001-03-30 Added SYNONYM class III PI3K
2001-03-30 Added TERM 1-phosphatidylinositol 3-kinase

Term

Timestamp Action Category Detail
2011-01-30 Updated TERM phosphatidylinositol 3-kinase complex
2003-10-07 Updated TERM phosphoinositide 3-kinase complex
2002-05-24 Updated TERM 1-phosphatidylinositol 3-kinase complex
2002-02-06 Updated TERM 1-phosphatidylinositol 3-kinase
2001-04-03 Updated TERM 1-phosphatidylinositol 3-kinase
2001-03-30 Added TERM 1-phosphatidylinositol 3-kinase

Definition/synonyms

Timestamp Action Category Detail
2014-09-18 Added DEFINITION A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
2014-09-18 Deleted DEFINITION A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphatidylinositol 3-kinase (PI3K).
2011-01-30 Deleted DEFINITION A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K).
2011-01-30 Added DEFINITION A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphatidylinositol 3-kinase (PI3K).
2011-01-30 Deleted SYNONYM phosphatidylinositol 3-kinase complex
2011-01-30 Added SYNONYM phosphoinositide 3-kinase complex
2009-02-28 Added SYNONYM PI3-kinase p85-subunit alpha- PI3-kinase p110 complex
2009-02-28 Added SYNONYM PIK3CA-PIK3R1 complex
2009-02-16 Added SYNONYM PIK3C3-PIK3R4 complex
2009-02-16 Added SYNONYM phosphatidylinositol 3-kinase complex
2008-05-13 Added DEFINITION A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K).
2008-05-12 Deleted DEFINITION A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K).
2007-08-09 Added SYNONYM 1-phosphatidylinositol 3-kinase complex
2007-08-09 Added SYNONYM PI3K complex
2007-08-09 Deleted SYNONYM 1-phosphatidylinositol 3-kinase complex
2007-08-09 Deleted SYNONYM PI3K complex
2004-04-19 Added SYNONYM 1-phosphatidylinositol 3-kinase complex
2004-04-19 Added SYNONYM PI3K complex
2004-04-16 Deleted SYNONYM PI3K complex
2004-04-16 Deleted SYNONYM 1-phosphatidylinositol 3-kinase complex
2003-10-07 Deleted SYNONYM class III PI3K
2003-10-07 Added SYNONYM 1-phosphatidylinositol 3-kinase complex
2003-10-07 Added SYNONYM PI3K complex
2003-10-07 Added DEFINITION A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K).
2001-03-30 Added SYNONYM class III PI3K

Relationships

Timestamp Action Category Detail
2015-03-19 Added RELATION is a GO:0044425 (membrane part)
2015-03-18 Added RELATION part of GO:0019898 (extrinsic component of membrane)
2015-03-18 Deleted RELATION is a GO:0044445 (cytosolic part)
2013-11-28 Added RELATION is a GO:1990234 (transferase complex)
2013-11-28 Deleted RELATION is a GO:1902494 (catalytic complex)
2013-11-15 Added RELATION is a GO:1902494 (catalytic complex)
2013-11-15 Deleted RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0044445 (cytosolic part)

Other

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_pir
2008-06-09 Added SLIM goslim_pir
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