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GO:0005923 tight junction

An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.

Term Information

ID GO:0005923
Name tight junction
Ontology Cellular Component
Definition An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
Comment

Synonyms

Type Synonym
exact zonula occludens

Cross-references associated with this term:

Database ID
INTERPRO IPR017974
INTERPRO IPR002958
INTERPRO IPR003928
INTERPRO IPR003927
INTERPRO IPR003926
INTERPRO IPR003925
INTERPRO IPR003556
INTERPRO IPR003555
INTERPRO IPR003554
INTERPRO IPR003553
INTERPRO IPR003552
INTERPRO IPR003551
INTERPRO IPR003550
INTERPRO IPR003549
INTERPRO IPR003548
INTERPRO IPR008094
INTERPRO IPR005420
INTERPRO IPR005419
INTERPRO IPR005418
INTERPRO IPR005417
INTERPRO IPR005411
INTERPRO IPR006187
Wikipedia Tight_junction

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Ancestor Chart

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Ancestor Table

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GO:0005575 cellular_component
GO:0005623 cell
GO:0044464 cell part
GO:0016020 membrane
GO:0005886 plasma membrane
GO:0044425 membrane part
GO:0044459 plasma membrane part
GO:0030054 cell junction
GO:0016327 apicolateral plasma membrane
GO:0005911 cell-cell junction
GO:0070160 occluding junction
GO:0043296 apical junction complex
GO:0005923 tight junction

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
Term has no children

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
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Format

Co-occurring Terms

Co-occurrence statistics

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