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GO:0005923 tight junction

Term Information

ID GO:0005923
Name tight junction
Ontology Cellular Component
Definition An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
GONUTS GO:0005923 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact zonula occludens

Cross-references

Database ID
InterPro IPR002958
InterPro IPR003548
InterPro IPR003549
InterPro IPR003550
InterPro IPR003551
InterPro IPR003552
InterPro IPR003553
InterPro IPR003554
InterPro IPR003555
InterPro IPR003556
InterPro IPR003925
InterPro IPR003926
InterPro IPR003927
InterPro IPR003928
InterPro IPR005411
InterPro IPR005417
InterPro IPR005418
InterPro IPR005419
InterPro IPR005420
InterPro IPR006187
InterPro IPR008094
InterPro IPR017974
InterPro IPR028179
NIF_Subcellular sao1939999134
UniProtKB-KW Tight junction
UniProtKB-SubCell Tight junction
Wikipedia Tight_junction

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005923:
Relationship To GO:0005923 Child Term Child Term Name
Is a GO:0044647 host-symbiont tight junction

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
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GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0005923. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0005923 based on the entire annotation set Co-occurrence statistics for GO:0005923 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-06-24 Added RELATION part of GO:0043296 (apical junction complex)
2010-06-24 Deleted RELATION is a GO:0043296 (apical junction complex)
2010-05-27 Added RELATION is a GO:0043296 (apical junction complex)
2010-05-27 Deleted RELATION part of GO:0043296 (apical junction complex)
2010-02-04 Added XREF NIF_Subcellular:sao1939999134
2009-02-08 Added XREF Wikipedia:Tight_junction
2008-11-27 Deleted DEFINITION A belt-like region of very close contact between the plasma membranes of adjacent cells so that the intercellular space is completely occluded. They occur in epithelia and brain endothelia.
2008-11-27 Added DEFINITION An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
2008-11-27 Added RELATION is a GO:0070160 (occluding junction)
2008-11-27 Deleted RELATION is a GO:0005911 (cell-cell junction)
2008-05-13 Added DEFINITION A belt-like region of very close contact between the plasma membranes of adjacent cells so that the intercellular space is completely occluded. They occur in epithelia and brain endothelia.
2008-05-12 Deleted DEFINITION A belt-like region of very close contact between the plasma membranes of adjacent cells so that the intercellular space is completely occluded. They occur in epithelia and brain endothelia.
2008-04-01 Updated RELATION is a GO:0005911 (cell-cell junction)
2008-04-01 Updated RELATION part of GO:0043296 (apical junction complex)
2007-08-09 Added SYNONYM zonula occludens
2007-08-09 Deleted SYNONYM zonula occludens
2004-04-19 Added SYNONYM zonula occludens
2004-04-16 Deleted SYNONYM zonula occludens
2002-02-06 Updated TERM tight junction
2001-08-06 Added DEFINITION A belt-like region of very close contact between the plasma membranes of adjacent cells so that the intercellular space is completely occluded. They occur in epithelia and brain endothelia.
2001-04-03 Updated TERM tight junction
2001-03-30 Added SYNONYM zonula occludens
2001-03-30 Added TERM tight junction

Term

Timestamp Action Category Detail
2002-02-06 Updated TERM tight junction
2001-04-03 Updated TERM tight junction
2001-03-30 Added TERM tight junction

Definition/synonyms

Timestamp Action Category Detail
2008-11-27 Deleted DEFINITION A belt-like region of very close contact between the plasma membranes of adjacent cells so that the intercellular space is completely occluded. They occur in epithelia and brain endothelia.
2008-11-27 Added DEFINITION An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
2008-05-13 Added DEFINITION A belt-like region of very close contact between the plasma membranes of adjacent cells so that the intercellular space is completely occluded. They occur in epithelia and brain endothelia.
2008-05-12 Deleted DEFINITION A belt-like region of very close contact between the plasma membranes of adjacent cells so that the intercellular space is completely occluded. They occur in epithelia and brain endothelia.
2007-08-09 Added SYNONYM zonula occludens
2007-08-09 Deleted SYNONYM zonula occludens
2004-04-19 Added SYNONYM zonula occludens
2004-04-16 Deleted SYNONYM zonula occludens
2001-08-06 Added DEFINITION A belt-like region of very close contact between the plasma membranes of adjacent cells so that the intercellular space is completely occluded. They occur in epithelia and brain endothelia.
2001-03-30 Added SYNONYM zonula occludens

Relationships

Timestamp Action Category Detail
2010-06-24 Added RELATION part of GO:0043296 (apical junction complex)
2010-06-24 Deleted RELATION is a GO:0043296 (apical junction complex)
2010-05-27 Added RELATION is a GO:0043296 (apical junction complex)
2010-05-27 Deleted RELATION part of GO:0043296 (apical junction complex)
2008-11-27 Added RELATION is a GO:0070160 (occluding junction)
2008-11-27 Deleted RELATION is a GO:0005911 (cell-cell junction)
2008-04-01 Updated RELATION is a GO:0005911 (cell-cell junction)
2008-04-01 Updated RELATION part of GO:0043296 (apical junction complex)

Cross-references

Timestamp Action Category Detail
2010-02-04 Added XREF NIF_Subcellular:sao1939999134
2009-02-08 Added XREF Wikipedia:Tight_junction
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