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GO:0005834 heterotrimeric G-protein complex

Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein.

Term Information

ID GO:0005834
Name heterotrimeric G-protein complex
Ontology Cellular Component
Definition Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein.
Comment See also the molecular function term 'G-protein coupled receptor activity ; GO:0004930'.

Synonyms

Type Synonym
narrow heterotrimeric G-protein GTPase, alpha-subunit
narrow heterotrimeric G-protein GTPase, gamma-subunit
narrow heterotrimeric G-protein GTPase, beta-subunit
related heterotrimeric G-protein GTPase activity

Cross-references associated with this term:

Database ID
INTERPRO IPR001770
INTERPRO IPR015898

This term can be used instead of these obsolete terms:

GO:0003927 heterotrimeric G-protein GTPase activity (replaced_by GO:0005834)
GO:0005065 heterotrimeric G-protein (replaced_by GO:0005834)
GO:0000263 heterotrimeric G-protein GTPase, alpha-subunit (consider GO:0005834)
GO:0000265 heterotrimeric G-protein GTPase, gamma-subunit (consider GO:0005834)
GO:0000264 heterotrimeric G-protein GTPase, beta-subunit (consider GO:0005834)

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GO:0005575 cellular_component
GO:0032991 macromolecular complex
GO:0005623 cell
GO:0043234 protein complex
GO:0044464 cell part
GO:0016020 membrane
GO:0005886 plasma membrane
GO:0044425 membrane part
GO:0019898 extrinsic to membrane
GO:0044459 plasma membrane part
GO:0019897 extrinsic to plasma membrane
GO:0005834 heterotrimeric G-protein complex

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
Term has no children

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
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Co-occurring Terms

Co-occurrence statistics

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