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GO:0005757 mitochondrial permeability transition pore complex

Term Information

ID GO:0005757
Name mitochondrial permeability transition pore complex
Ontology Cellular Component
Definition A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D).
PMID:10393078
GONUTS GO:0005757 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
broad PTPC
exact MPTP complex
exact mitochondrial PT pore complex

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0005623 cell only_in_taxon 131567 cellular organisms
GO:0005739 mitochondrion only_in_taxon 2759 Eukaryota
More information on taxon constraints in GO is available here

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005757:
Term has no children

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0005757. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0005757 based on the entire annotation set Co-occurrence statistics for GO:0005757 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2015-06-25 Deleted RELATION is a GO:0044429 (mitochondrial part)
2015-05-11 Added RELATION is a GO:0098798 (mitochondrial protein complex)
2014-02-08 Added SYNONYM PTPC
2014-02-08 Deleted DEFINITION A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol.
2014-02-08 Added DEFINITION A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D).
2013-11-07 Added SYNONYM MPTP complex
2008-05-13 Added DEFINITION A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol.
2008-05-12 Deleted DEFINITION A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol.
2008-04-01 Updated RELATION is a GO:0044429 (mitochondrial part)
2008-04-01 Updated RELATION is a GO:0046930 (pore complex)
2008-04-01 Updated RELATION part of GO:0005740 (mitochondrial envelope)
2007-08-09 Added SYNONYM mitochondrial PT pore complex
2007-08-09 Deleted SYNONYM mitochondrial PT pore complex
2007-03-08 Deleted SYNONYM mitochondrial PT pore
2007-03-08 Added SYNONYM mitochondrial PT pore complex
2007-03-08 Updated TERM mitochondrial permeability transition pore complex
2007-03-06 Added DEFINITION A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol.
2004-04-19 Added SYNONYM mitochondrial PT pore
2004-04-16 Deleted SYNONYM mitochondrial PT pore
2002-02-06 Updated TERM mitochondrial permeability transition pore
2001-06-29 Added SYNONYM mitochondrial PT pore
2001-06-29 Updated TERM mitochondrial permeability transition pore
2001-04-03 Updated TERM mitochondrial PT pore
2001-03-30 Added TERM mitochondrial PT pore

Term

Timestamp Action Category Detail
2007-03-08 Updated TERM mitochondrial permeability transition pore complex
2002-02-06 Updated TERM mitochondrial permeability transition pore
2001-06-29 Updated TERM mitochondrial permeability transition pore
2001-04-03 Updated TERM mitochondrial PT pore
2001-03-30 Added TERM mitochondrial PT pore

Definition/synonyms

Timestamp Action Category Detail
2014-02-08 Added SYNONYM PTPC
2014-02-08 Deleted DEFINITION A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol.
2014-02-08 Added DEFINITION A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D).
2013-11-07 Added SYNONYM MPTP complex
2008-05-13 Added DEFINITION A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol.
2008-05-12 Deleted DEFINITION A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol.
2007-08-09 Added SYNONYM mitochondrial PT pore complex
2007-08-09 Deleted SYNONYM mitochondrial PT pore complex
2007-03-08 Deleted SYNONYM mitochondrial PT pore
2007-03-08 Added SYNONYM mitochondrial PT pore complex
2007-03-06 Added DEFINITION A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol.
2004-04-19 Added SYNONYM mitochondrial PT pore
2004-04-16 Deleted SYNONYM mitochondrial PT pore
2001-06-29 Added SYNONYM mitochondrial PT pore

Relationships

Timestamp Action Category Detail
2015-06-25 Deleted RELATION is a GO:0044429 (mitochondrial part)
2015-05-11 Added RELATION is a GO:0098798 (mitochondrial protein complex)
2008-04-01 Updated RELATION is a GO:0044429 (mitochondrial part)
2008-04-01 Updated RELATION is a GO:0046930 (pore complex)
2008-04-01 Updated RELATION part of GO:0005740 (mitochondrial envelope)
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