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GO:0005747 mitochondrial respiratory chain complex I

A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.

Term Information

ID GO:0005747
Name mitochondrial respiratory chain complex I
Ontology Cellular Component
Definition A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.
Comment

Cross-references associated with this term:

Database ID
INTERPRO IPR016551

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Ancestor Chart

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Chart

Ancestor Table

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GO:0005575 cellular_component
GO:0032991 macromolecular complex
GO:0043226 organelle
GO:0005623 cell
GO:0031975 envelope
GO:0043234 protein complex
GO:0043227 membrane-bounded organelle
GO:0044422 organelle part
GO:0044464 cell part
GO:0016020 membrane
GO:0005622 intracellular
GO:0044424 intracellular part
GO:0044425 membrane part
GO:0005737 cytoplasm
GO:0070469 respiratory chain
GO:0044444 cytoplasmic part
GO:0043229 intracellular organelle
GO:0031090 organelle membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0044446 intracellular organelle part
GO:0030964 NADH dehydrogenase complex
GO:0031967 organelle envelope
GO:0005739 mitochondrion
GO:0045271 respiratory chain complex I
GO:0019866 organelle inner membrane
GO:0044429 mitochondrial part
GO:0005740 mitochondrial envelope
GO:0031966 mitochondrial membrane
GO:0044455 mitochondrial membrane part
GO:0005743 mitochondrial inner membrane
GO:0005746 mitochondrial respiratory chain
GO:0005747 mitochondrial respiratory chain complex I

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
P GO:0042652 mitochondrial respiratory chain complex I, peripheral segment
P GO:0042653 mitochondrial respiratory chain complex I, membrane segment

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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15ms
Stand-alone
Hostnametomcat-7.ebi.ac.uk
Uptime16:38 12/10/2009
Data version2009-11-21-04-03-45
Terminal
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