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GO:0005730 nucleolus

A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

Term Information

ID GO:0005730
Name nucleolus
Ontology Cellular Component
Definition A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
Comment

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_candida91
goslim_generic127
goslim_pir470
goslim_plant102
goslim_yeast93

Cross-references associated with this term:

Database ID
Wikipedia Nucleolus
INTERPRO IPR010613
INTERPRO IPR018983
INTERPRO IPR017265

Web service: term information

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Ancestor Chart

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Chart

Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0005575 cellular_component
GO:0031974 membrane-enclosed lumen
GO:0005623 cell
GO:0043226 organelle
GO:0043228 non-membrane-bounded organelle
GO:0044464 cell part
GO:0043227 membrane-bounded organelle
GO:0044422 organelle part
GO:0005622 intracellular
GO:0044424 intracellular part
GO:0043233 organelle lumen
GO:0043229 intracellular organelle
GO:0043232 intracellular non-membrane-bounded organelle
GO:0043231 intracellular membrane-bounded organelle
GO:0044446 intracellular organelle part
GO:0005634 nucleus
GO:0070013 intracellular organelle lumen
GO:0044428 nuclear part
GO:0031981 nuclear lumen
GO:0005730 nucleolus

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
P GO:0044452 nucleolar part

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

This display shows those GO terms which have been annotated to the same proteins as this term.
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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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