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GO:0005680 anaphase-promoting complex

A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.

Term Information

ID GO:0005680
Name anaphase-promoting complex
Ontology Cellular Component
Definition A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
Comment Note that the synonym 'APC' should not be confused with the abbreviation for the adenomatous polyposis coli gene and protein.

Synonyms

Type Synonym
exact cyclosome
exact anaphase promoting complex
broad APC

Cross-references associated with this term:

Database ID
INTERPRO IPR004939
INTERPRO IPR007192
Wikipedia Anaphase-promoting_complex
INTERPRO IPR008402

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Ancestor Table

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GO:0005575 cellular_component
GO:0032991 macromolecular complex
GO:0005623 cell
GO:0043226 organelle
GO:0043227 membrane-bounded organelle
GO:0044464 cell part
GO:0043234 protein complex
GO:0044422 organelle part
GO:0005622 intracellular
GO:0044424 intracellular part
GO:0043229 intracellular organelle
GO:0000151 ubiquitin ligase complex
GO:0043231 intracellular membrane-bounded organelle
GO:0044446 intracellular organelle part
GO:0005634 nucleus
GO:0044428 nuclear part
GO:0000152 nuclear ubiquitin ligase complex
GO:0005680 anaphase-promoting complex

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
Term has no children

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
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Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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