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GO:0005680 anaphase-promoting complex

Term Information

ID GO:0005680
Name anaphase-promoting complex
Ontology Cellular Component
Definition A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
PMID:10465783 PMID:10611969
Comment Note that the synonym 'APC' should not be confused with the abbreviation for the adenomatous polyposis coli gene and protein.
GONUTS GO:0005680 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
broad APC
exact anaphase promoting complex
exact cyclosome

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000057 GO:0005623 cell only_in_taxon 131567 cellular organisms
GOTAX:0000059 GO:0005634 nucleus only_in_taxon 2759 Eukaryota
More information on taxon constraints in GO is available here

Protein complexes

Database ID Name
IntAct apc_yeast-1 Anaphase-Promoting Complex variant 1
IntAct apc_yeast-2 Anaphase-Promoting Complex variant 2
IntAct apc_yeast-3 Anaphase-Promoting Complex variant 3
IntAct apc_yeast-4 Anaphase-Promoting Complex variant 4
IntAct apc_schpo-1 Anaphase-Promoting Complex variant 1
IntAct apc_schpo-2 Anaphase-Promoting Complex variant 2
IntAct apc_schpo-3 Anaphase-Promoting Complex variant 3
IntAct apc_schpo-4 Anaphase-Promoting Complex variant 4

Cross-references

Database ID
InterPro IPR007192
InterPro IPR008402
InterPro IPR016807
InterPro IPR016901
InterPro IPR017169
InterPro IPR018860
InterPro IPR024789
InterPro IPR024990
InterPro IPR024991
InterPro IPR026182
InterPro IPR029641
Wikipedia Anaphase-promoting_complex

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005680:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
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Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
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Date
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Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0005680. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0005680 based on the entire annotation set Co-occurrence statistics for GO:0005680 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-03-23 Added RELATION is a GO:0031461 (cullin-RING ubiquitin ligase complex)
2009-02-05 Added XREF Wikipedia:Anaphase-promoting_complex
2008-08-31 Deleted SYNONYM APC
2008-08-31 Added SYNONYM APC
2008-05-13 Added DEFINITION A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
2008-05-12 Deleted DEFINITION A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
2008-04-01 Updated RELATION is a GO:0000152 (nuclear ubiquitin ligase complex)
2007-08-09 Added SYNONYM APC
2007-08-09 Added SYNONYM anaphase promoting complex
2007-08-09 Added SYNONYM cyclosome
2007-08-09 Deleted SYNONYM APC
2007-08-09 Deleted SYNONYM anaphase promoting complex
2007-08-09 Deleted SYNONYM cyclosome
2006-08-28 Added SYNONYM anaphase promoting complex
2005-04-20 Updated DEFINITION A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
2004-04-19 Added SYNONYM APC
2004-04-19 Added SYNONYM cyclosome
2004-04-16 Deleted SYNONYM APC
2004-04-16 Deleted SYNONYM cyclosome
2002-02-06 Updated TERM anaphase-promoting complex
2001-08-06 Added DEFINITION A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis.
2001-04-03 Updated TERM anaphase-promoting complex
2001-03-30 Added SYNONYM APC
2001-03-30 Added SYNONYM cyclosome
2001-03-30 Added TERM anaphase-promoting complex

Term

Timestamp Action Category Detail
2002-02-06 Updated TERM anaphase-promoting complex
2001-04-03 Updated TERM anaphase-promoting complex
2001-03-30 Added TERM anaphase-promoting complex

Definition/synonyms

Timestamp Action Category Detail
2008-08-31 Deleted SYNONYM APC
2008-08-31 Added SYNONYM APC
2008-05-13 Added DEFINITION A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
2008-05-12 Deleted DEFINITION A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
2007-08-09 Added SYNONYM APC
2007-08-09 Added SYNONYM anaphase promoting complex
2007-08-09 Added SYNONYM cyclosome
2007-08-09 Deleted SYNONYM APC
2007-08-09 Deleted SYNONYM anaphase promoting complex
2007-08-09 Deleted SYNONYM cyclosome
2006-08-28 Added SYNONYM anaphase promoting complex
2005-04-20 Updated DEFINITION A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
2004-04-19 Added SYNONYM APC
2004-04-19 Added SYNONYM cyclosome
2004-04-16 Deleted SYNONYM APC
2004-04-16 Deleted SYNONYM cyclosome
2001-08-06 Added DEFINITION A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis.
2001-03-30 Added SYNONYM APC
2001-03-30 Added SYNONYM cyclosome

Relationships

Timestamp Action Category Detail
2011-03-23 Added RELATION is a GO:0031461 (cullin-RING ubiquitin ligase complex)
2008-04-01 Updated RELATION is a GO:0000152 (nuclear ubiquitin ligase complex)

Cross-references

Timestamp Action Category Detail
2009-02-05 Added XREF Wikipedia:Anaphase-promoting_complex
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