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GO:0005665 DNA-directed RNA polymerase II, core complex

RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.

Term Information

ID GO:0005665
Name DNA-directed RNA polymerase II, core complex
Ontology Cellular Component
Definition RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
Comment

Synonyms

Type Synonym
broad RNAP II complex
broad RNA polymerase II complex

Cross-references associated with this term:

Database ID
INTERPRO IPR000684

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Ancestor Chart

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Chart

Ancestor Table

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GO:0005575 cellular_component
GO:0043226 organelle
GO:0032991 macromolecular complex
GO:0031974 membrane-enclosed lumen
GO:0005623 cell
GO:0043227 membrane-bounded organelle
GO:0044464 cell part
GO:0044422 organelle part
GO:0043234 protein complex
GO:0005622 intracellular
GO:0044424 intracellular part
GO:0043233 organelle lumen
GO:0043229 intracellular organelle
GO:0030880 RNA polymerase complex
GO:0044446 intracellular organelle part
GO:0000428 DNA-directed RNA polymerase complex
GO:0043231 intracellular membrane-bounded organelle
GO:0005634 nucleus
GO:0055029 nuclear DNA-directed RNA polymerase complex
GO:0070013 intracellular organelle lumen
GO:0044428 nuclear part
GO:0031981 nuclear lumen
GO:0005654 nucleoplasm
GO:0044451 nucleoplasm part
GO:0016591 DNA-directed RNA polymerase II, holoenzyme
GO:0005665 DNA-directed RNA polymerase II, core complex

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
Term has no children

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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14ms
Stand-alone
Hostnametomcat-7.ebi.ac.uk
Uptime16:38 12/10/2009
Data version2009-11-22-04-02-35
Terminal
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