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GO:0005579 membrane attack complex

Term Information

ID GO:0005579
Name membrane attack complex
Ontology Cellular Component
Definition A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
GONUTS GO:0005579 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow membrane attack complex protein beta2 chain
narrow membrane attack complex protein alphaM chain
exact MAC
exact terminal complement complex
exact TCC

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000057 GO:0005623 cell only_in_taxon 131567 cellular organisms
More information on taxon constraints in GO is available here

Cross-references

Database ID
InterPro IPR001862
UniProtKB-KW Membrane attack complex
Wikipedia Complement_membrane_attack_complex

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0005580 membrane attack complex protein alphaM chain REPLACEDBY GO:0005579
GO:0008008 membrane attack complex protein beta2 chain REPLACEDBY GO:0005579

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005579:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0005579. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0005579 based on the entire annotation set Co-occurrence statistics for GO:0005579 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2009-12-10 Deleted RELATION is a GO:0043234 (protein complex)
2009-02-05 Added XREF Wikipedia:Complement_membrane_attack_complex
2008-10-02 Added DEFINITION A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
2008-10-02 Deleted DEFINITION A complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
2008-10-02 Added RELATION is a GO:0044459 (plasma membrane part)
2008-10-02 Added RELATION part of GO:0005887 (integral component of plasma membrane)
2008-05-13 Added DEFINITION A complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
2008-05-12 Deleted DEFINITION A complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0046930 (pore complex)
2007-08-09 Added SYNONYM MAC
2007-08-09 Added SYNONYM TCC
2007-08-09 Added SYNONYM membrane attack complex protein alphaM chain
2007-08-09 Added SYNONYM membrane attack complex protein beta2 chain
2007-08-09 Added SYNONYM terminal complement complex
2007-08-09 Deleted SYNONYM MAC
2007-08-09 Deleted SYNONYM TCC
2007-08-09 Deleted SYNONYM membrane attack complex protein alphaM chain
2007-08-09 Deleted SYNONYM membrane attack complex protein beta2 chain
2007-08-09 Deleted SYNONYM terminal complement complex
2005-08-10 Added SYNONYM membrane attack complex protein alphaM chain
2005-08-10 Added SYNONYM membrane attack complex protein beta2 chain
2004-04-19 Added SYNONYM MAC
2004-04-19 Added SYNONYM TCC
2004-04-19 Added SYNONYM terminal complement complex
2004-04-16 Deleted SYNONYM MAC
2004-04-16 Deleted SYNONYM TCC
2004-04-16 Deleted SYNONYM terminal complement complex
2003-11-04 Added SYNONYM MAC
2003-11-04 Added SYNONYM TCC
2003-11-04 Added SYNONYM terminal complement complex
2003-11-04 Updated DEFINITION A complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
2002-11-27 Updated DEFINITION A cell-surface glycoprotein of monocytes, macrophages, and granulocytes that is implicated in the adhesive interactions of these cells as well as in mediating the uptake of complement-coated particles. It probably recognizes the RGD peptide in complement component C3b. It is a heterodimer of alphaM and beta2 chains (mouse).
2002-02-06 Updated TERM membrane attack complex
2001-08-06 Added DEFINITION A cell-surface glycoprotein of monocytes, macrophages, and granulocytes that is implicated in the adhesive interactions of these cells as well as in mediating the uptake of complement-coated particles. It probably recognises the RGD peptide in complement component C3b. It is a heterodimer of &agr;<down>M</down> and &bgr;<down>2</down> chains (mouse).
2001-04-03 Updated TERM membrane attack complex
2001-03-30 Added TERM membrane attack complex

Term

Timestamp Action Category Detail
2002-02-06 Updated TERM membrane attack complex
2001-04-03 Updated TERM membrane attack complex
2001-03-30 Added TERM membrane attack complex

Definition/synonyms

Timestamp Action Category Detail
2008-10-02 Added DEFINITION A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
2008-10-02 Deleted DEFINITION A complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
2008-05-13 Added DEFINITION A complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
2008-05-12 Deleted DEFINITION A complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
2007-08-09 Added SYNONYM MAC
2007-08-09 Added SYNONYM TCC
2007-08-09 Added SYNONYM membrane attack complex protein alphaM chain
2007-08-09 Added SYNONYM membrane attack complex protein beta2 chain
2007-08-09 Added SYNONYM terminal complement complex
2007-08-09 Deleted SYNONYM MAC
2007-08-09 Deleted SYNONYM TCC
2007-08-09 Deleted SYNONYM membrane attack complex protein alphaM chain
2007-08-09 Deleted SYNONYM membrane attack complex protein beta2 chain
2007-08-09 Deleted SYNONYM terminal complement complex
2005-08-10 Added SYNONYM membrane attack complex protein alphaM chain
2005-08-10 Added SYNONYM membrane attack complex protein beta2 chain
2004-04-19 Added SYNONYM MAC
2004-04-19 Added SYNONYM TCC
2004-04-19 Added SYNONYM terminal complement complex
2004-04-16 Deleted SYNONYM MAC
2004-04-16 Deleted SYNONYM TCC
2004-04-16 Deleted SYNONYM terminal complement complex
2003-11-04 Added SYNONYM MAC
2003-11-04 Added SYNONYM TCC
2003-11-04 Added SYNONYM terminal complement complex
2003-11-04 Updated DEFINITION A complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
2002-11-27 Updated DEFINITION A cell-surface glycoprotein of monocytes, macrophages, and granulocytes that is implicated in the adhesive interactions of these cells as well as in mediating the uptake of complement-coated particles. It probably recognizes the RGD peptide in complement component C3b. It is a heterodimer of alphaM and beta2 chains (mouse).
2001-08-06 Added DEFINITION A cell-surface glycoprotein of monocytes, macrophages, and granulocytes that is implicated in the adhesive interactions of these cells as well as in mediating the uptake of complement-coated particles. It probably recognises the RGD peptide in complement component C3b. It is a heterodimer of &agr;<down>M</down> and &bgr;<down>2</down> chains (mouse).

Relationships

Timestamp Action Category Detail
2009-12-10 Deleted RELATION is a GO:0043234 (protein complex)
2008-10-02 Added RELATION is a GO:0044459 (plasma membrane part)
2008-10-02 Added RELATION part of GO:0005887 (integral component of plasma membrane)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0046930 (pore complex)

Cross-references

Timestamp Action Category Detail
2009-02-05 Added XREF Wikipedia:Complement_membrane_attack_complex
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