spacer

GO:0005576 extracellular region

Term Information

ID GO:0005576
Name extracellular region
Ontology Cellular Component
Definition The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
Comment Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'.
GONUTS GO:0005576 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact extracellular

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_candida89
goslim_generic149
goslim_pir462
goslim_plant100
goslim_yeast169
goslim_aspergillus85

Cross-references

Database ID
InterPro IPR000013
InterPro IPR000020
InterPro IPR000065
InterPro IPR000074
InterPro IPR000083
InterPro IPR000096
InterPro IPR000098
InterPro IPR000117
InterPro IPR000177
InterPro IPR000186
InterPro IPR000187
InterPro IPR000226
InterPro IPR000254
InterPro IPR000275
InterPro IPR000294
InterPro IPR000346
InterPro IPR000381
InterPro IPR000400
InterPro IPR000443
InterPro IPR000471
InterPro IPR000476
InterPro IPR000491
InterPro IPR000512
InterPro IPR000532
InterPro IPR000663
InterPro IPR000693
InterPro IPR000773
InterPro IPR000779
InterPro IPR000827
InterPro IPR000867
InterPro IPR000875
InterPro IPR000877
InterPro IPR000879
InterPro IPR000981
InterPro IPR001028
InterPro IPR001089
InterPro IPR001144
InterPro IPR001166
InterPro IPR001181
InterPro IPR001219
InterPro IPR001262
InterPro IPR001299
InterPro IPR001318
InterPro IPR001323
InterPro IPR001325
InterPro IPR001400
InterPro IPR001415
InterPro IPR001483
InterPro IPR001489
InterPro IPR001545
InterPro IPR001581
InterPro IPR001588
InterPro IPR001615
InterPro IPR001651
InterPro IPR001693
InterPro IPR001710
InterPro IPR001729
InterPro IPR001811
InterPro IPR001835
InterPro IPR001840
InterPro IPR001855
InterPro IPR001894
InterPro IPR001928
InterPro IPR001941
InterPro IPR001947
InterPro IPR001955
InterPro IPR001981
InterPro IPR002012
InterPro IPR002047
InterPro IPR002061
InterPro IPR002069
InterPro IPR002098
InterPro IPR002116
InterPro IPR002169
InterPro IPR002183
InterPro IPR002200
InterPro IPR002336
InterPro IPR002354
InterPro IPR002384
InterPro IPR002405
InterPro IPR002406
InterPro IPR002407
InterPro IPR002408
InterPro IPR002463
InterPro IPR002473
InterPro IPR002557
InterPro IPR002633
InterPro IPR002964
InterPro IPR003013
InterPro IPR003159
InterPro IPR003189
InterPro IPR003235
InterPro IPR003294
InterPro IPR003295
InterPro IPR003296
InterPro IPR003424
InterPro IPR003443
InterPro IPR003540
InterPro IPR003541
InterPro IPR003571
InterPro IPR003572
InterPro IPR003573
InterPro IPR003574
InterPro IPR003610
InterPro IPR003620
InterPro IPR003624
InterPro IPR003625
InterPro IPR003626
InterPro IPR003842
InterPro IPR003895
InterPro IPR003896
InterPro IPR003897
InterPro IPR003898
InterPro IPR003899
InterPro IPR003963
InterPro IPR003978
InterPro IPR003995
InterPro IPR004093
InterPro IPR004103
InterPro IPR004126
InterPro IPR004169
InterPro IPR004214
InterPro IPR004236
InterPro IPR004250
InterPro IPR004275
InterPro IPR004281
InterPro IPR004315
InterPro IPR004825
InterPro IPR004898
InterPro IPR004943
InterPro IPR004978
InterPro IPR005015
InterPro IPR005165
InterPro IPR005413
InterPro IPR005414
InterPro IPR005441
InterPro IPR005453
InterPro IPR005520
InterPro IPR005521
InterPro IPR005795
InterPro IPR005817
InterPro IPR005830
InterPro IPR005831
InterPro IPR005832
InterPro IPR006079
InterPro IPR006080
InterPro IPR006081
InterPro IPR006123
InterPro IPR006126
InterPro IPR006718
InterPro IPR006719
InterPro IPR006720
InterPro IPR006737
InterPro IPR006738
InterPro IPR006742
InterPro IPR006781
InterPro IPR006796
InterPro IPR006801
InterPro IPR007118
InterPro IPR007464
InterPro IPR007682
InterPro IPR007733
InterPro IPR007958
InterPro IPR007962
InterPro IPR007988
InterPro IPR007990
InterPro IPR008017
InterPro IPR008034
InterPro IPR008036
InterPro IPR008055
InterPro IPR008064
InterPro IPR008097
InterPro IPR008105
InterPro IPR008120
InterPro IPR008124
InterPro IPR008174
InterPro IPR008175
InterPro IPR008197
InterPro IPR008292
InterPro IPR008296
InterPro IPR008363
InterPro IPR008364
InterPro IPR008375
InterPro IPR008392
InterPro IPR008403
InterPro IPR008405
InterPro IPR008412
InterPro IPR008453
InterPro IPR008605
InterPro IPR008612
InterPro IPR008660
InterPro IPR008675
InterPro IPR008836
InterPro IPR008857
InterPro IPR008859
InterPro IPR008873
InterPro IPR008911
InterPro IPR009048
InterPro IPR009139
InterPro IPR009140
InterPro IPR009141
InterPro IPR009142
InterPro IPR009143
InterPro IPR009168
InterPro IPR009243
InterPro IPR009382
InterPro IPR009396
InterPro IPR009415
InterPro IPR009438
InterPro IPR009456
InterPro IPR009458
InterPro IPR009608
InterPro IPR009714
InterPro IPR009911
InterPro IPR009958
InterPro IPR009990
InterPro IPR010000
InterPro IPR010002
InterPro IPR010009
InterPro IPR010012
InterPro IPR010126
InterPro IPR010345
InterPro IPR010500
InterPro IPR010503
InterPro IPR010636
InterPro IPR010711
InterPro IPR010801
InterPro IPR010831
InterPro IPR010857
InterPro IPR010892
InterPro IPR011099
InterPro IPR011100
InterPro IPR011150
InterPro IPR011175
InterPro IPR011329
InterPro IPR011360
InterPro IPR011390
InterPro IPR011395
InterPro IPR011505
InterPro IPR011696
InterPro IPR012210
InterPro IPR012211
InterPro IPR012213
InterPro IPR012321
InterPro IPR012322
InterPro IPR012325
InterPro IPR012497
InterPro IPR012498
InterPro IPR012499
InterPro IPR012500
InterPro IPR012518
InterPro IPR012520
InterPro IPR012521
InterPro IPR012522
InterPro IPR012523
InterPro IPR012524
InterPro IPR012525
InterPro IPR012526
InterPro IPR012527
InterPro IPR012528
InterPro IPR012529
InterPro IPR012534
InterPro IPR012553
InterPro IPR012593
InterPro IPR012608
InterPro IPR012619
InterPro IPR012622
InterPro IPR012624
InterPro IPR012625
InterPro IPR012626
InterPro IPR012627
InterPro IPR012628
InterPro IPR012629
InterPro IPR012630
InterPro IPR012631
InterPro IPR012632
InterPro IPR012633
InterPro IPR012634
InterPro IPR012635
InterPro IPR012636
InterPro IPR012637
InterPro IPR012928
InterPro IPR013300
InterPro IPR013301
InterPro IPR013302
InterPro IPR013303
InterPro IPR013304
InterPro IPR014610
InterPro IPR015290
InterPro IPR015476
InterPro IPR016091
InterPro IPR016179
InterPro IPR016183
InterPro IPR016289
InterPro IPR016326
InterPro IPR017100
InterPro IPR017227
InterPro IPR017273
InterPro IPR017329
InterPro IPR017760
InterPro IPR017766
InterPro IPR017913
InterPro IPR017914
InterPro IPR017915
InterPro IPR018048
InterPro IPR018049
InterPro IPR018051
InterPro IPR018096
InterPro IPR018116
InterPro IPR018142
InterPro IPR018195
InterPro IPR018216
InterPro IPR018224
InterPro IPR018244
InterPro IPR018245
InterPro IPR018251
InterPro IPR018354
InterPro IPR018360
InterPro IPR018504
InterPro IPR018992
InterPro IPR019764
InterPro IPR019767
InterPro IPR019806
InterPro IPR019827
InterPro IPR020063
InterPro IPR020329
InterPro IPR020432
InterPro IPR020440
InterPro IPR020453
InterPro IPR020466
InterPro IPR020520
InterPro IPR021116
InterPro IPR021117
InterPro IPR021118
InterPro IPR022321
InterPro IPR022322
InterPro IPR022326
InterPro IPR022327
InterPro IPR022421
InterPro IPR022423
InterPro IPR024175
InterPro IPR026999
InterPro IPR028130
InterPro IPR028138
InterPro IPR028196
InterPro IPR028210
InterPro IPR028223
InterPro IPR028232
InterPro IPR028239
InterPro IPR028240
InterPro IPR028242
InterPro IPR028247
InterPro IPR028249
InterPro IPR028251
InterPro IPR028252
InterPro IPR028253
InterPro IPR028279
InterPro IPR028284
InterPro IPR028285
InterPro IPR028287
InterPro IPR028289
InterPro IPR028291
InterPro IPR028292
InterPro IPR028296
InterPro IPR028303
InterPro IPR028304
InterPro IPR028469
InterPro IPR028507
InterPro IPR028711
InterPro IPR028829
InterPro IPR029094
InterPro IPR029396
InterPro IPR029837
InterPro IPR029860
InterPro IPR029864
UniProtKB-KW Secreted
UniProtKB-KW Surface film
UniProtKB-SubCell Secreted
Wikipedia Extracellular

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0008530 exogenous peptide receptor activity CONSIDER GO:0005576
GO:0019845 exotoxin activity CONSIDER GO:0005576
GO:0004624 secreted phospholipase A2 activity REPLACEDBY GO:0005576
GO:0004625 calcium-dependent secreted phospholipase A2 activity REPLACEDBY GO:0005576

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005576:
Relationship To GO:0005576 Child Term Child Term Name
Is a GO:0048046 apoplast
Part of GO:0044421 extracellular region part
Is a GO:0098595 perivitelline space
Occurs in GO:1900115 extracellular regulation of signal transduction
Occurs in GO:1900116 extracellular negative regulation of signal transduction

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0005576. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0005576 based on the entire annotation set Co-occurrence statistics for GO:0005576 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_aspergillus
2013-04-18 Updated SLIM goslim_yeast
2013-04-18 Updated SLIM goslim_plant
2013-04-18 Updated SLIM goslim_pir
2013-04-18 Updated SLIM goslim_generic
2013-04-18 Updated SLIM goslim_candida
2011-11-05 Added SLIM goslim_aspergillus
2011-03-18 Deleted SLIM goslim_goa
2009-02-05 Added XREF Wikipedia:Extracellular
2008-06-09 Added SLIM goslim_yeast
2008-06-09 Added SLIM goslim_plant
2008-06-09 Added SLIM goslim_pir
2008-06-09 Added SLIM goslim_goa
2008-06-09 Added SLIM goslim_generic
2008-06-09 Added SLIM goslim_candida
2008-05-13 Added DEFINITION The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2008-05-12 Deleted DEFINITION The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2008-04-01 Updated RELATION is a GO:0005575 (cellular_component)
2007-08-09 Added SYNONYM extracellular
2007-08-09 Deleted SYNONYM extracellular
2005-10-28 Deleted SYNONYM exogenous peptide receptor activity
2005-10-28 Deleted SYNONYM exotoxin activity
2005-10-28 Deleted SYNONYM secreted phospholipase A2 activity
2005-10-28 Deleted SYNONYM calcium-dependent secreted phospholipase A2 activity
2005-08-10 Added SYNONYM calcium-dependent secreted phospholipase A2 activity
2005-08-10 Added SYNONYM exogenous peptide receptor activity
2005-08-10 Added SYNONYM exotoxin activity
2005-08-10 Added SYNONYM secreted phospholipase A2 activity
2004-11-12 Added SYNONYM extracellular
2004-11-12 Updated TERM extracellular region
2003-06-11 Updated DEFINITION The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2003-03-26 Added DEFINITION The space external to the outermost structure of a cell or virus. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite, including the space external to a virus.
2001-04-03 Updated TERM extracellular
2001-03-30 Added TERM extracellular

Term

Timestamp Action Category Detail
2004-11-12 Updated TERM extracellular region
2001-04-03 Updated TERM extracellular
2001-03-30 Added TERM extracellular

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2008-05-12 Deleted DEFINITION The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2007-08-09 Added SYNONYM extracellular
2007-08-09 Deleted SYNONYM extracellular
2005-10-28 Deleted SYNONYM exogenous peptide receptor activity
2005-10-28 Deleted SYNONYM exotoxin activity
2005-10-28 Deleted SYNONYM secreted phospholipase A2 activity
2005-10-28 Deleted SYNONYM calcium-dependent secreted phospholipase A2 activity
2005-08-10 Added SYNONYM calcium-dependent secreted phospholipase A2 activity
2005-08-10 Added SYNONYM exogenous peptide receptor activity
2005-08-10 Added SYNONYM exotoxin activity
2005-08-10 Added SYNONYM secreted phospholipase A2 activity
2004-11-12 Added SYNONYM extracellular
2003-06-11 Updated DEFINITION The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2003-03-26 Added DEFINITION The space external to the outermost structure of a cell or virus. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite, including the space external to a virus.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0005575 (cellular_component)

Cross-references

Timestamp Action Category Detail
2009-02-05 Added XREF Wikipedia:Extracellular

Other

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_aspergillus
2013-04-18 Updated SLIM goslim_yeast
2013-04-18 Updated SLIM goslim_plant
2013-04-18 Updated SLIM goslim_pir
2013-04-18 Updated SLIM goslim_generic
2013-04-18 Updated SLIM goslim_candida
2011-11-05 Added SLIM goslim_aspergillus
2011-03-18 Deleted SLIM goslim_goa
2008-06-09 Added SLIM goslim_yeast
2008-06-09 Added SLIM goslim_plant
2008-06-09 Added SLIM goslim_pir
2008-06-09 Added SLIM goslim_goa
2008-06-09 Added SLIM goslim_generic
2008-06-09 Added SLIM goslim_candida
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
22ms