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GO:0005432 calcium:sodium antiporter activity

Term Information

ID GO:0005432
Name calcium:sodium antiporter activity
Ontology Molecular Function
Definition Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in).
PMID:16371597
GONUTS GO:0005432 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related mitochondrial sodium/calcium ion exchange
related sodium:calcium exchange
exact sodium/calcium exchanger

Cross-references

Database ID
InterPro IPR002987
InterPro IPR004836

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0006852 mitochondrial sodium/calcium ion exchange CONSIDER GO:0005432
GO:0030181 sodium:calcium exchange CONSIDER GO:0005432

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005432:
Relationship To GO:0005432 Child Term Child Term Name
Regulates GO:1903279 regulation of calcium:sodium antiporter activity
Negatively regulates GO:1903280 negative regulation of calcium:sodium antiporter activity
Positively regulates GO:1903281 positive regulation of calcium:sodium antiporter activity
Is a GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential

Protein Annotation

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GO Identifier
GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0005432. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0005432 based on the entire annotation set Co-occurrence statistics for GO:0005432 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-01-10 Added RELATION is a GO:0015081 (sodium ion transmembrane transporter activity)
2010-06-09 Updated TERM calcium:sodium antiporter activity
2010-06-08 Updated TERM calcium:sodium antiporter activity
2008-05-13 Added DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in).
2008-05-12 Deleted DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in).
2008-04-01 Updated RELATION is a GO:0015368 (calcium:cation antiporter activity)
2007-08-09 Added SYNONYM mitochondrial sodium/calcium ion exchange
2007-08-09 Added SYNONYM sodium/calcium exchanger
2007-08-09 Added SYNONYM sodium:calcium exchange
2007-08-09 Deleted SYNONYM mitochondrial sodium/calcium ion exchange
2007-08-09 Deleted SYNONYM sodium/calcium exchanger
2007-08-09 Deleted SYNONYM sodium:calcium exchange
2007-07-27 Updated DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in).
2007-07-11 Deleted XREF TC:2.A.19.3.1
2005-08-10 Added SYNONYM mitochondrial sodium/calcium ion exchange
2005-08-10 Added SYNONYM sodium:calcium exchange
2003-03-26 Updated DEFINITION Catalysis of the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in).
2003-03-19 Updated TERM calcium:sodium antiporter activity
2002-02-06 Updated TERM calcium:sodium antiporter
2001-08-06 Added DEFINITION Rapid transport of calcium ions during excitation-contraction coupling; calcium ions are extruded from the cell during relaxation, so as to prevent overloading of intracellular calcium stores.
2001-04-03 Updated TERM calcium:sodium antiporter
2001-03-30 Added XREF TC:2.A.19.3.1
2001-03-30 Added SYNONYM sodium/calcium exchanger
2001-03-30 Added TERM calcium:sodium antiporter

Term

Timestamp Action Category Detail
2010-06-09 Updated TERM calcium:sodium antiporter activity
2010-06-08 Updated TERM calcium:sodium antiporter activity
2003-03-19 Updated TERM calcium:sodium antiporter activity
2002-02-06 Updated TERM calcium:sodium antiporter
2001-04-03 Updated TERM calcium:sodium antiporter
2001-03-30 Added TERM calcium:sodium antiporter

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in).
2008-05-12 Deleted DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in).
2007-08-09 Added SYNONYM mitochondrial sodium/calcium ion exchange
2007-08-09 Added SYNONYM sodium/calcium exchanger
2007-08-09 Added SYNONYM sodium:calcium exchange
2007-08-09 Deleted SYNONYM mitochondrial sodium/calcium ion exchange
2007-08-09 Deleted SYNONYM sodium/calcium exchanger
2007-08-09 Deleted SYNONYM sodium:calcium exchange
2007-07-27 Updated DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in).
2005-08-10 Added SYNONYM mitochondrial sodium/calcium ion exchange
2005-08-10 Added SYNONYM sodium:calcium exchange
2003-03-26 Updated DEFINITION Catalysis of the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in).
2001-08-06 Added DEFINITION Rapid transport of calcium ions during excitation-contraction coupling; calcium ions are extruded from the cell during relaxation, so as to prevent overloading of intracellular calcium stores.
2001-03-30 Added SYNONYM sodium/calcium exchanger

Relationships

Timestamp Action Category Detail
2011-01-10 Added RELATION is a GO:0015081 (sodium ion transmembrane transporter activity)
2008-04-01 Updated RELATION is a GO:0015368 (calcium:cation antiporter activity)

Cross-references

Timestamp Action Category Detail
2007-07-11 Deleted XREF TC:2.A.19.3.1
2001-03-30 Added XREF TC:2.A.19.3.1
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