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GO:0005391 sodium:potassium-exchanging ATPase activity

Term Information

ID GO:0005391
Name sodium:potassium-exchanging ATPase activity
Ontology Molecular Function
Definition Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
GONUTS GO:0005391 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact (Na+ + K+)-ATPase activity
exact sodium:potassium exchanging ATPase activity
exact ATP phosphohydrolase (Na+/K+-exchanging)
related Na+,K+ pump
exact Na+,K+-ATPase activity
exact Na+/K+-ATPase activity
exact Na+/K+-exchanging ATPase activity
related Na,K-pump
exact Na(+)/K(+)-ATPase activity
exact Na(+)/K(+)-exchanging ATPase activity
exact Na,K-activated ATPase activity
exact sodium/potassium-transporting ATPase activity
broad sodium pump
exact sodium/potassium-exchanging ATPase activity
exact (Na+ + K+)-activated ATPase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.6.3.9
MetaCyc 3.6.3.9-RXN
RHEA 18356

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005391:
Relationship To GO:0005391 Child Term Child Term Name
Is a GO:0086037 sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0005391. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0005391 based on the entire annotation set Co-occurrence statistics for GO:0005391 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-10-28 Deleted SYNONYM na+/K+-exchanging ATPase activity
2011-09-16 Added XREF RHEA:18356
2010-09-03 Deleted RELATION is a GO:0015662 (ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism)
2010-06-09 Updated TERM sodium:potassium-exchanging ATPase activity
2010-06-08 Added RELATION is a GO:0015081 (sodium ion transmembrane transporter activity)
2010-06-08 Updated TERM sodium:potassium-exchanging ATPase activity
2010-06-04 Added RELATION is a GO:0008556 (potassium-transporting ATPase activity)
2008-05-13 Added DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
2008-05-12 Deleted DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
2008-04-01 Updated RELATION is a GO:0015662 (ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism)
2007-11-08 Added SYNONYM (Na+ + K+)-ATPase activity
2007-11-08 Added SYNONYM (Na+ + K+)-activated ATPase activity
2007-11-08 Added SYNONYM ATP phosphohydrolase (Na+/K+-exchanging)
2007-11-08 Added SYNONYM Na+,K+ pump
2007-11-08 Added SYNONYM Na+,K+-ATPase activity
2007-11-08 Added SYNONYM Na+/K+-ATPase activity
2007-11-08 Added SYNONYM Na+/K+-exchanging ATPase activity
2007-11-08 Added SYNONYM Na,K-pump
2007-11-08 Added SYNONYM na+/K+-exchanging ATPase activity
2007-09-06 Added SYNONYM sodium/potassium-transporting ATPase activity
2007-09-06 Added SYNONYM Na(+)/K(+)-ATPase activity
2007-09-06 Added SYNONYM Na(+)/K(+)-exchanging ATPase activity
2007-09-06 Added SYNONYM Na,K-activated ATPase activity
2007-08-09 Added SYNONYM sodium pump
2007-08-09 Added SYNONYM sodium/potassium-exchanging ATPase activity
2007-08-09 Added SYNONYM sodium:potassium exchanging ATPase activity
2007-08-09 Deleted SYNONYM sodium pump
2007-08-09 Deleted SYNONYM sodium/potassium-exchanging ATPase activity
2007-08-09 Deleted SYNONYM sodium:potassium exchanging ATPase activity
2007-07-27 Updated DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
2007-07-11 Deleted XREF TC:3.A.3.1.2
2007-07-11 Deleted XREF TC:3.A.3.1.1
2005-07-29 Added SYNONYM sodium:potassium exchanging ATPase activity
2004-07-26 Updated TERM sodium:potassium-exchanging ATPase activity
2004-07-26 Added SYNONYM sodium/potassium-exchanging ATPase activity
2004-04-19 Added SYNONYM sodium pump
2004-04-16 Deleted SYNONYM sodium pump
2003-10-27 Added SYNONYM sodium pump
2003-10-27 Added XREF TC:3.A.3.1.1
2003-10-27 Added XREF MetaCyc:3.6.3.9-RXN
2003-10-27 Added XREF TC:3.A.3.1.2
2003-08-21 Deleted SYNONYM sodium pump
2003-08-21 Deleted XREF TC:3.A.3.1.2
2003-08-21 Deleted XREF TC:3.A.3.1.1
2003-03-26 Updated DEFINITION Catalysis of the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
2003-03-19 Updated TERM sodium/potassium-exchanging ATPase activity
2002-11-27 Updated DEFINITION Catalysis of the efflux of three sodium ions and influx of two potassium ions per ATP hydrolyzed. It is apparently involved in generating the plasma membrane electrical potential.
2002-02-06 Updated TERM sodium/potassium-exchanging ATPase
2001-08-06 Added DEFINITION A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This is a plasma membrane enzyme, ubiquitous in animal cells, that catalyses the efflux of three sodium ions and influx of two potassium ions per ATP hydrolysed. It is apparently involved in generating the plasma membrane electrical potential.
2001-04-03 Updated TERM sodium/potassium-exchanging ATPase
2001-03-30 Added XREF TC:3.A.3.1.2
2001-03-30 Added XREF TC:3.A.3.1.1
2001-03-30 Added XREF EC:3.6.3.9
2001-03-30 Added SYNONYM sodium pump
2001-03-30 Added TERM sodium/potassium-exchanging ATPase

Term

Timestamp Action Category Detail
2010-06-09 Updated TERM sodium:potassium-exchanging ATPase activity
2010-06-08 Updated TERM sodium:potassium-exchanging ATPase activity
2004-07-26 Updated TERM sodium:potassium-exchanging ATPase activity
2003-03-19 Updated TERM sodium/potassium-exchanging ATPase activity
2002-02-06 Updated TERM sodium/potassium-exchanging ATPase
2001-04-03 Updated TERM sodium/potassium-exchanging ATPase
2001-03-30 Added TERM sodium/potassium-exchanging ATPase

Definition/synonyms

Timestamp Action Category Detail
2011-10-28 Deleted SYNONYM na+/K+-exchanging ATPase activity
2008-05-13 Added DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
2008-05-12 Deleted DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
2007-11-08 Added SYNONYM (Na+ + K+)-ATPase activity
2007-11-08 Added SYNONYM (Na+ + K+)-activated ATPase activity
2007-11-08 Added SYNONYM ATP phosphohydrolase (Na+/K+-exchanging)
2007-11-08 Added SYNONYM Na+,K+ pump
2007-11-08 Added SYNONYM Na+,K+-ATPase activity
2007-11-08 Added SYNONYM Na+/K+-ATPase activity
2007-11-08 Added SYNONYM Na+/K+-exchanging ATPase activity
2007-11-08 Added SYNONYM Na,K-pump
2007-11-08 Added SYNONYM na+/K+-exchanging ATPase activity
2007-09-06 Added SYNONYM sodium/potassium-transporting ATPase activity
2007-09-06 Added SYNONYM Na(+)/K(+)-ATPase activity
2007-09-06 Added SYNONYM Na(+)/K(+)-exchanging ATPase activity
2007-09-06 Added SYNONYM Na,K-activated ATPase activity
2007-08-09 Added SYNONYM sodium pump
2007-08-09 Added SYNONYM sodium/potassium-exchanging ATPase activity
2007-08-09 Added SYNONYM sodium:potassium exchanging ATPase activity
2007-08-09 Deleted SYNONYM sodium pump
2007-08-09 Deleted SYNONYM sodium/potassium-exchanging ATPase activity
2007-08-09 Deleted SYNONYM sodium:potassium exchanging ATPase activity
2007-07-27 Updated DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
2005-07-29 Added SYNONYM sodium:potassium exchanging ATPase activity
2004-07-26 Added SYNONYM sodium/potassium-exchanging ATPase activity
2004-04-19 Added SYNONYM sodium pump
2004-04-16 Deleted SYNONYM sodium pump
2003-10-27 Added SYNONYM sodium pump
2003-08-21 Deleted SYNONYM sodium pump
2003-03-26 Updated DEFINITION Catalysis of the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
2002-11-27 Updated DEFINITION Catalysis of the efflux of three sodium ions and influx of two potassium ions per ATP hydrolyzed. It is apparently involved in generating the plasma membrane electrical potential.
2001-08-06 Added DEFINITION A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This is a plasma membrane enzyme, ubiquitous in animal cells, that catalyses the efflux of three sodium ions and influx of two potassium ions per ATP hydrolysed. It is apparently involved in generating the plasma membrane electrical potential.
2001-03-30 Added SYNONYM sodium pump

Relationships

Timestamp Action Category Detail
2010-09-03 Deleted RELATION is a GO:0015662 (ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism)
2010-06-08 Added RELATION is a GO:0015081 (sodium ion transmembrane transporter activity)
2010-06-04 Added RELATION is a GO:0008556 (potassium-transporting ATPase activity)
2008-04-01 Updated RELATION is a GO:0015662 (ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism)

Cross-references

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:18356
2007-07-11 Deleted XREF TC:3.A.3.1.2
2007-07-11 Deleted XREF TC:3.A.3.1.1
2003-10-27 Added XREF TC:3.A.3.1.1
2003-10-27 Added XREF MetaCyc:3.6.3.9-RXN
2003-10-27 Added XREF TC:3.A.3.1.2
2003-08-21 Deleted XREF TC:3.A.3.1.2
2003-08-21 Deleted XREF TC:3.A.3.1.1
2001-03-30 Added XREF TC:3.A.3.1.2
2001-03-30 Added XREF TC:3.A.3.1.1
2001-03-30 Added XREF EC:3.6.3.9
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