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GO:0005242 inward rectifier potassium channel activity

Term Information

ID GO:0005242
Name inward rectifier potassium channel activity
Ontology Molecular Function
Definition Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.
PMID:14977398
GONUTS GO:0005242 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact Kir channel activity

Cross-references

Database ID
InterPro IPR003268
InterPro IPR003269
InterPro IPR003270
InterPro IPR003271
InterPro IPR003272
InterPro IPR003273
InterPro IPR008061
InterPro IPR008062
InterPro IPR016449

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0005241 obsolete inward rectifier channel CONSIDER GO:0005242

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005242:
Relationship To GO:0005242 Child Term Child Term Name
Is a GO:0015272 ATP-activated inward rectifier potassium channel activity
Is a GO:0015467 G-protein activated inward rectifier potassium channel activity
Capable of GO:1902937 inward rectifier potassium channel complex
Capable of GO:1990374 Kir2 inward rectifier potassium channel complex
Negatively regulates GO:1903609 negative regulation of inward rectifier potassium channel activity
Regulates GO:1901979 regulation of inward rectifier potassium channel activity
Positively regulates GO:1901980 positive regulation of inward rectifier potassium channel activity

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0005242. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0005242 based on the entire annotation set Co-occurrence statistics for GO:0005242 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2015-05-11 Deleted DEFINITION Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.
2015-05-11 Added DEFINITION Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.
2009-02-13 Added DEFINITION Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.
2009-02-13 Added SYNONYM Kir channel activity
2009-02-13 Added RELATION is a GO:0015276 (ligand-gated ion channel activity)
2008-04-01 Updated RELATION is a GO:0005249 (voltage-gated potassium channel activity)
2007-10-06 Deleted SYNONYM inward rectifier channel
2007-08-09 Added SYNONYM inward rectifier channel
2007-08-09 Deleted SYNONYM inward rectifier channel
2007-07-11 Deleted XREF TC:1.A.1.8.1
2005-08-10 Added SYNONYM inward rectifier channel
2003-03-19 Updated TERM inward rectifier potassium channel activity
2002-02-06 Updated TERM inward rectifier potassium channel
2001-04-03 Updated TERM inward rectifier potassium channel
2001-03-30 Added XREF TC:1.A.1.8.1
2001-03-30 Added TERM inward rectifier potassium channel

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM inward rectifier potassium channel activity
2002-02-06 Updated TERM inward rectifier potassium channel
2001-04-03 Updated TERM inward rectifier potassium channel
2001-03-30 Added TERM inward rectifier potassium channel

Definition/synonyms

Timestamp Action Category Detail
2015-05-11 Deleted DEFINITION Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.
2015-05-11 Added DEFINITION Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.
2009-02-13 Added DEFINITION Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.
2009-02-13 Added SYNONYM Kir channel activity
2007-10-06 Deleted SYNONYM inward rectifier channel
2007-08-09 Added SYNONYM inward rectifier channel
2007-08-09 Deleted SYNONYM inward rectifier channel
2005-08-10 Added SYNONYM inward rectifier channel

Relationships

Timestamp Action Category Detail
2009-02-13 Added RELATION is a GO:0015276 (ligand-gated ion channel activity)
2008-04-01 Updated RELATION is a GO:0005249 (voltage-gated potassium channel activity)

Cross-references

Timestamp Action Category Detail
2007-07-11 Deleted XREF TC:1.A.1.8.1
2001-03-30 Added XREF TC:1.A.1.8.1
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