spacer

GO:0005089 Rho guanyl-nucleotide exchange factor activity

Term Information

ID GO:0005089
Name Rho guanyl-nucleotide exchange factor activity
Ontology Molecular Function
Definition Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
GONUTS GO:0005089 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact Rho guanine nucleotide exchange factor
exact RhoGEF

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Binding term considerationsLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
InterPro IPR000219
InterPro IPR005512
InterPro IPR015212
InterPro IPR028569

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005089:
Relationship To GO:0005089 Child Term Child Term Name
Is a GO:0030676 Rac guanyl-nucleotide exchange factor activity
Regulates GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity
Negatively regulates GO:2001107 negative regulation of Rho guanyl-nucleotide exchange factor activity
Positively regulates GO:2001108 positive regulation of Rho guanyl-nucleotide exchange factor activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0005089. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0005089 based on the entire annotation set Co-occurrence statistics for GO:0005089 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-06-11 Added RELATION part of GO:0032321 (positive regulation of Rho GTPase activity)
2014-06-11 Deleted RELATION part of GO:0032319 (regulation of Rho GTPase activity)
2013-11-15 Added RELATION part of GO:0032319 (regulation of Rho GTPase activity)
2009-12-15 Added DEFINITION Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2009-12-15 Deleted DEFINITION Stimulates the exchange of guanyl nucleotides by a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2008-05-13 Added DEFINITION Stimulates the exchange of guanyl nucleotides by a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2008-05-12 Deleted DEFINITION Stimulates the exchange of guanyl nucleotides by a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2008-04-01 Updated RELATION is a GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
2007-08-09 Added SYNONYM Rho guanine nucleotide exchange factor
2007-08-09 Added SYNONYM RhoGEF
2007-08-09 Deleted SYNONYM Rho guanine nucleotide exchange factor
2007-08-09 Deleted SYNONYM RhoGEF
2006-10-03 Updated DEFINITION Stimulates the exchange of guanyl nucleotides by a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2006-04-14 Updated DEFINITION Stimulates the exchange of guanyl nucleotides by the GTPase Rho. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2004-10-03 Updated DEFINITION Stimulates the exchange of guanyl nucleotides by the GTPase Rho.
2004-04-19 Added SYNONYM Rho guanine nucleotide exchange factor
2004-04-19 Added SYNONYM RhoGEF
2004-04-16 Deleted SYNONYM Rho guanine nucleotide exchange factor
2004-04-16 Deleted SYNONYM RhoGEF
2003-04-25 Added DEFINITION Stimulates the hydrolysis and exchange of guanyl nucleotides by the GTPase Rho.
2003-03-19 Updated TERM Rho guanyl-nucleotide exchange factor activity
2003-03-19 Deleted SYNONYM RHO guanine nucleotide exchange factor
2002-06-06 Updated TERM Rho guanyl-nucleotide exchange factor
2002-06-06 Added SYNONYM Rho guanine nucleotide exchange factor
2002-02-06 Updated TERM RHO guanyl-nucleotide exchange factor
2001-08-22 Added SYNONYM RhoGEF
2001-08-22 Added SYNONYM RHO guanine nucleotide exchange factor
2001-04-03 Updated TERM RHO guanyl-nucleotide exchange factor
2001-03-30 Added TERM RHO guanyl-nucleotide exchange factor

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM Rho guanyl-nucleotide exchange factor activity
2002-06-06 Updated TERM Rho guanyl-nucleotide exchange factor
2002-02-06 Updated TERM RHO guanyl-nucleotide exchange factor
2001-04-03 Updated TERM RHO guanyl-nucleotide exchange factor
2001-03-30 Added TERM RHO guanyl-nucleotide exchange factor

Definition/synonyms

Timestamp Action Category Detail
2009-12-15 Added DEFINITION Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2009-12-15 Deleted DEFINITION Stimulates the exchange of guanyl nucleotides by a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2008-05-13 Added DEFINITION Stimulates the exchange of guanyl nucleotides by a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2008-05-12 Deleted DEFINITION Stimulates the exchange of guanyl nucleotides by a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2007-08-09 Added SYNONYM Rho guanine nucleotide exchange factor
2007-08-09 Added SYNONYM RhoGEF
2007-08-09 Deleted SYNONYM Rho guanine nucleotide exchange factor
2007-08-09 Deleted SYNONYM RhoGEF
2006-10-03 Updated DEFINITION Stimulates the exchange of guanyl nucleotides by a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2006-04-14 Updated DEFINITION Stimulates the exchange of guanyl nucleotides by the GTPase Rho. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2004-10-03 Updated DEFINITION Stimulates the exchange of guanyl nucleotides by the GTPase Rho.
2004-04-19 Added SYNONYM Rho guanine nucleotide exchange factor
2004-04-19 Added SYNONYM RhoGEF
2004-04-16 Deleted SYNONYM Rho guanine nucleotide exchange factor
2004-04-16 Deleted SYNONYM RhoGEF
2003-04-25 Added DEFINITION Stimulates the hydrolysis and exchange of guanyl nucleotides by the GTPase Rho.
2003-03-19 Deleted SYNONYM RHO guanine nucleotide exchange factor
2002-06-06 Added SYNONYM Rho guanine nucleotide exchange factor
2001-08-22 Added SYNONYM RhoGEF
2001-08-22 Added SYNONYM RHO guanine nucleotide exchange factor

Relationships

Timestamp Action Category Detail
2014-06-11 Added RELATION part of GO:0032321 (positive regulation of Rho GTPase activity)
2014-06-11 Deleted RELATION part of GO:0032319 (regulation of Rho GTPase activity)
2013-11-15 Added RELATION part of GO:0032319 (regulation of Rho GTPase activity)
2008-04-01 Updated RELATION is a GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
14ms