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GO:0005085 guanyl-nucleotide exchange factor activityStimulates the exchange of guanyl nucleotides by a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
Term Information
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| Type | Synonym |
| exact | GEF |
| narrow | GNRP |
| exact | guanyl-nucleotide release factor activity |
| exact | guanyl-nucleotide releasing factor |
| Database | ID |
| INTERPRO | IPR008937 |
| INTERPRO | IPR007515 |
| INTERPRO | IPR005414 |
| INTERPRO | IPR019804 |
| INTERPRO | IPR001331 |
| INTERPRO | IPR000651 |
| INTERPRO | IPR010703 |
| INTERPRO | IPR001895 |
| INTERPRO | IPR016019 |
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0003674 molecular_function | ||||
![]() | GO:0030234 enzyme regulator activity | |||
![]() | ![]() | GO:0060589 nucleoside-triphosphatase regulator activity | ||
![]() | ![]() | ![]() | GO:0030695 GTPase regulator activity | |
![]() | ![]() | ![]() | ![]() | GO:0005085 guanyl-nucleotide exchange factor activity |
| Code | Relationship |
![]() | part of |
![]() | is a |
![]() | regulates |
![]() | +ve regulates |
![]() | -ve regulates |
| I | GO:0017132 cyclic nucleotide-dependent guanyl-nucleotide exchange factor activity |
| I | GO:0005086 ARF guanyl-nucleotide exchange factor activity |
| I | GO:0005088 Ras guanyl-nucleotide exchange factor activity |
| I | GO:0005090 Sar guanyl-nucleotide exchange factor activity |
| Code | Relationship |
| P | part of |
| I | is a |
| Hostname | tomcat-7.ebi.ac.uk |
| Uptime | 16:38 12/10/2009 |
| Data version | 2009-11-23-04-03-36 |