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GO:0005078 MAP-kinase scaffold activity

Term Information

ID GO:0005078
Name MAP-kinase scaffold activity
Ontology Molecular Function
Definition The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently.
PMID:12511654 PMID:15213240 PMID:9405336
GONUTS GO:0005078 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact MAP-kinase scaffold protein activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Binding term considerationsLink

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005078:
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Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0005078. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0005078 based on the entire annotation set Co-occurrence statistics for GO:0005078 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-06-22 Added RELATION is a GO:0019900 (kinase binding)
2011-03-06 Deleted DEFINITION Functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. MAPK scaffold proteins have binding sites for MAPK pathway kinases as well as for upstream signaling proteins.
2011-03-06 Added DEFINITION The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently.
2011-03-06 Added RELATION is a GO:0035591 (signaling adaptor activity)
2011-03-06 Added RELATION is a GO:0032947 (protein complex scaffold)
2011-03-06 Deleted RELATION is a GO:0030159 (receptor signaling complex scaffold activity)
2008-05-13 Added DEFINITION Functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. MAPK scaffold proteins have binding sites for MAPK pathway kinases as well as for upstream signaling proteins.
2008-05-12 Deleted DEFINITION Functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. MAPK scaffold proteins have binding sites for MAPK pathway kinases as well as for upstream signaling proteins.
2008-04-01 Updated RELATION is a GO:0030159 (receptor signaling complex scaffold activity)
2007-08-09 Added SYNONYM MAP-kinase scaffold protein activity
2007-08-09 Deleted SYNONYM MAP-kinase scaffold protein activity
2007-02-20 Updated DEFINITION Functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. MAPK scaffold proteins have binding sites for MAPK pathway kinases as well as for upstream signaling proteins.
2004-04-19 Added SYNONYM MAP-kinase scaffold protein activity
2004-04-16 Deleted SYNONYM MAP-kinase scaffold protein activity
2003-07-24 Updated TERM MAP-kinase scaffold activity
2003-07-24 Added DEFINITION Functions as a scaffold for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. MAPK scaffold proteins have binding sites for MAPK pathway kinases as well as for upstream signaling proteins.
2003-07-24 Added SYNONYM MAP-kinase scaffold protein activity
2003-03-19 Updated TERM MAP-kinase scaffold protein activity
2002-02-06 Updated TERM MAP-kinase scaffold protein
2001-04-03 Updated TERM MAP-kinase scaffold protein
2001-03-30 Added TERM MAP-kinase scaffold protein

Term

Timestamp Action Category Detail
2003-07-24 Updated TERM MAP-kinase scaffold activity
2003-03-19 Updated TERM MAP-kinase scaffold protein activity
2002-02-06 Updated TERM MAP-kinase scaffold protein
2001-04-03 Updated TERM MAP-kinase scaffold protein
2001-03-30 Added TERM MAP-kinase scaffold protein

Definition/synonyms

Timestamp Action Category Detail
2011-03-06 Deleted DEFINITION Functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. MAPK scaffold proteins have binding sites for MAPK pathway kinases as well as for upstream signaling proteins.
2011-03-06 Added DEFINITION The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently.
2008-05-13 Added DEFINITION Functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. MAPK scaffold proteins have binding sites for MAPK pathway kinases as well as for upstream signaling proteins.
2008-05-12 Deleted DEFINITION Functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. MAPK scaffold proteins have binding sites for MAPK pathway kinases as well as for upstream signaling proteins.
2007-08-09 Added SYNONYM MAP-kinase scaffold protein activity
2007-08-09 Deleted SYNONYM MAP-kinase scaffold protein activity
2007-02-20 Updated DEFINITION Functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. MAPK scaffold proteins have binding sites for MAPK pathway kinases as well as for upstream signaling proteins.
2004-04-19 Added SYNONYM MAP-kinase scaffold protein activity
2004-04-16 Deleted SYNONYM MAP-kinase scaffold protein activity
2003-07-24 Added DEFINITION Functions as a scaffold for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. MAPK scaffold proteins have binding sites for MAPK pathway kinases as well as for upstream signaling proteins.
2003-07-24 Added SYNONYM MAP-kinase scaffold protein activity

Relationships

Timestamp Action Category Detail
2014-06-22 Added RELATION is a GO:0019900 (kinase binding)
2011-03-06 Added RELATION is a GO:0035591 (signaling adaptor activity)
2011-03-06 Added RELATION is a GO:0032947 (protein complex scaffold)
2011-03-06 Deleted RELATION is a GO:0030159 (receptor signaling complex scaffold activity)
2008-04-01 Updated RELATION is a GO:0030159 (receptor signaling complex scaffold activity)
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