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GO:0005070 SH3/SH2 adaptor activity

Term Information

ID GO:0005070
Name SH3/SH2 adaptor activity
Ontology Molecular Function
Definition Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
GONUTS GO:0005070 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow SH3/SH2 adaptor protein activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Binding term considerationsLink

Cross-references

Database ID
InterPro IPR017289
InterPro IPR030219

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005070:
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Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0005070. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0005070 based on the entire annotation set Co-occurrence statistics for GO:0005070 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-11-25 Deleted RELATION is a GO:0004871 (signal transducer activity)
2010-11-07 Added RELATION is a GO:0035591 (signaling adaptor activity)
2010-11-07 Deleted RELATION is a GO:0060090 (binding, bridging)
2009-07-03 Deleted DEFINITION Interacting selectively and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
2009-07-03 Added DEFINITION Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
2008-05-13 Added DEFINITION Interacting selectively and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
2008-05-12 Deleted DEFINITION Interacting selectively and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
2008-04-01 Updated RELATION is a GO:0030674 (protein binding, bridging)
2008-04-01 Updated RELATION is a GO:0004871 (signal transducer activity)
2008-04-01 Updated RELATION is a GO:0060090 (binding, bridging)
2007-08-09 Added SYNONYM SH3/SH2 adaptor protein activity
2007-08-09 Deleted SYNONYM SH3/SH2 adaptor protein activity
2006-09-26 Updated DEFINITION Interacting selectively and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
2005-03-31 Updated DEFINITION Interacting selectively and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g.Grb2) or those of their target molecules (e.g. SAM68).
2005-03-21 Added SYNONYM SH3/SH2 adaptor protein activity
2005-03-21 Updated TERM SH3/SH2 adaptor activity
2005-03-19 Added DEFINITION Interacting selectively and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g.Grb2) or those of their target molecules (e.g. SAM68).
2003-03-19 Updated TERM SH3/SH2 adaptor protein activity
2002-02-06 Updated TERM SH3/SH2 adaptor protein
2001-04-03 Updated TERM SH3/SH2 adaptor protein
2001-03-30 Added TERM SH3/SH2 adaptor protein

Term

Timestamp Action Category Detail
2005-03-21 Updated TERM SH3/SH2 adaptor activity
2003-03-19 Updated TERM SH3/SH2 adaptor protein activity
2002-02-06 Updated TERM SH3/SH2 adaptor protein
2001-04-03 Updated TERM SH3/SH2 adaptor protein
2001-03-30 Added TERM SH3/SH2 adaptor protein

Definition/synonyms

Timestamp Action Category Detail
2009-07-03 Deleted DEFINITION Interacting selectively and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
2009-07-03 Added DEFINITION Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
2008-05-13 Added DEFINITION Interacting selectively and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
2008-05-12 Deleted DEFINITION Interacting selectively and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
2007-08-09 Added SYNONYM SH3/SH2 adaptor protein activity
2007-08-09 Deleted SYNONYM SH3/SH2 adaptor protein activity
2006-09-26 Updated DEFINITION Interacting selectively and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
2005-03-31 Updated DEFINITION Interacting selectively and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g.Grb2) or those of their target molecules (e.g. SAM68).
2005-03-21 Added SYNONYM SH3/SH2 adaptor protein activity
2005-03-19 Added DEFINITION Interacting selectively and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g.Grb2) or those of their target molecules (e.g. SAM68).

Relationships

Timestamp Action Category Detail
2010-11-25 Deleted RELATION is a GO:0004871 (signal transducer activity)
2010-11-07 Added RELATION is a GO:0035591 (signaling adaptor activity)
2010-11-07 Deleted RELATION is a GO:0060090 (binding, bridging)
2008-04-01 Updated RELATION is a GO:0030674 (protein binding, bridging)
2008-04-01 Updated RELATION is a GO:0004871 (signal transducer activity)
2008-04-01 Updated RELATION is a GO:0060090 (binding, bridging)
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