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GO:0005044 scavenger receptor activity

Term Information

ID GO:0005044
Name scavenger receptor activity
Ontology Molecular Function
Definition Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
PMID:11790542 PMID:12379907 PMID:12621157 PMID:20981357
Comment Note that many gene products that are called scavenger receptors have a broad range of potential ligands and also can be annotated to 'pattern recognition receptor activity ; GO:0008329' or its child terms, or to 'lipoprotein receptor activity ; GO:0030228' or its child terms. For receptors that transduce a signal rather than endocytose their ligand, consider instead the terms 'signaling receptor activity ; GO:0038023' and its children.
GONUTS GO:0005044 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow macrophage receptor activity

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_chembl310

Cross-references

Database ID
InterPro IPR001190
InterPro IPR001212
InterPro IPR003543
InterPro IPR005383
InterPro IPR020436
InterPro IPR026296
InterPro IPR033037
InterPro IPR033329

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0008019 obsolete macrophage receptor activity CONSIDER GO:0005044

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005044:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0005044. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0005044 based on the entire annotation set Co-occurrence statistics for GO:0005044 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2017-05-30 Added DEFINITION Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
2017-05-30 Deleted DEFINITION Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs).
2017-05-29 Deleted DEFINITION Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
2017-05-29 Added DEFINITION Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs).
2017-05-25 Deleted DEFINITION Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs).
2017-05-25 Added DEFINITION Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
2015-05-19 Added SLIM goslim_chembl
2015-05-19 Deleted SLIM goslim_ChEMBL
2015-05-11 Added SLIM goslim_ChEMBL
2011-08-04 Deleted DEFINITION Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand to initiate a change in cell activity. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs). Following ligand binding, scavenger receptors can mediate intracellular signaling and/or ligand internalization.
2011-08-04 Added DEFINITION Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs).
2011-08-04 Deleted RELATION is a GO:0004888 (transmembrane signaling receptor activity)
2011-08-04 Added RELATION is a GO:0038024 (cargo receptor activity)
2011-06-29 Deleted DEFINITION Combining with acetylated low-density lipoproteins, advanced glycation end products, or other polyanionic ligands to initiate a change in cell activity.
2011-06-29 Added DEFINITION Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand to initiate a change in cell activity. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs). Following ligand binding, scavenger receptors can mediate intracellular signaling and/or ligand internalization.
2011-06-29 Deleted SYNONYM macrophage receptor activity
2011-06-29 Added SYNONYM macrophage receptor activity
2008-05-13 Added DEFINITION Combining with acetylated low-density lipoproteins, advanced glycation end products, or other polyanionic ligands to initiate a change in cell activity.
2008-05-12 Deleted DEFINITION Combining with acetylated low-density lipoproteins, advanced glycation end products, or other polyanionic ligands to initiate a change in cell activity.
2008-04-01 Updated RELATION is a GO:0004888 (transmembrane signaling receptor activity)
2007-08-09 Added SYNONYM macrophage receptor activity
2007-08-09 Deleted SYNONYM macrophage receptor activity
2005-08-10 Added SYNONYM macrophage receptor activity
2004-05-30 Added DEFINITION Combining with acetylated low-density lipoproteins, advanced glycation end products, or other polyanionic ligands to initiate a change in cell activity.
2003-03-19 Updated TERM scavenger receptor activity
2002-02-06 Updated TERM scavenger receptor
2001-04-03 Updated TERM scavenger receptor
2001-03-30 Added TERM scavenger receptor

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM scavenger receptor activity
2002-02-06 Updated TERM scavenger receptor
2001-04-03 Updated TERM scavenger receptor
2001-03-30 Added TERM scavenger receptor

Definition/synonyms

Timestamp Action Category Detail
2017-05-30 Added DEFINITION Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
2017-05-30 Deleted DEFINITION Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs).
2017-05-29 Deleted DEFINITION Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
2017-05-29 Added DEFINITION Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs).
2017-05-25 Deleted DEFINITION Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs).
2017-05-25 Added DEFINITION Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
2011-08-04 Deleted DEFINITION Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand to initiate a change in cell activity. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs). Following ligand binding, scavenger receptors can mediate intracellular signaling and/or ligand internalization.
2011-08-04 Added DEFINITION Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs).
2011-06-29 Deleted DEFINITION Combining with acetylated low-density lipoproteins, advanced glycation end products, or other polyanionic ligands to initiate a change in cell activity.
2011-06-29 Added DEFINITION Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand to initiate a change in cell activity. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs). Following ligand binding, scavenger receptors can mediate intracellular signaling and/or ligand internalization.
2011-06-29 Deleted SYNONYM macrophage receptor activity
2011-06-29 Added SYNONYM macrophage receptor activity
2008-05-13 Added DEFINITION Combining with acetylated low-density lipoproteins, advanced glycation end products, or other polyanionic ligands to initiate a change in cell activity.
2008-05-12 Deleted DEFINITION Combining with acetylated low-density lipoproteins, advanced glycation end products, or other polyanionic ligands to initiate a change in cell activity.
2007-08-09 Added SYNONYM macrophage receptor activity
2007-08-09 Deleted SYNONYM macrophage receptor activity
2005-08-10 Added SYNONYM macrophage receptor activity
2004-05-30 Added DEFINITION Combining with acetylated low-density lipoproteins, advanced glycation end products, or other polyanionic ligands to initiate a change in cell activity.

Relationships

Timestamp Action Category Detail
2011-08-04 Deleted RELATION is a GO:0004888 (transmembrane signaling receptor activity)
2011-08-04 Added RELATION is a GO:0038024 (cargo receptor activity)
2008-04-01 Updated RELATION is a GO:0004888 (transmembrane signaling receptor activity)

Other

Timestamp Action Category Detail
2015-05-19 Added SLIM goslim_chembl
2015-05-19 Deleted SLIM goslim_ChEMBL
2015-05-11 Added SLIM goslim_ChEMBL
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