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GO:0005006 epidermal growth factor-activated receptor activity

Term Information

ID GO:0005006
Name epidermal growth factor-activated receptor activity
Ontology Molecular Function
Definition Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
Comment Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand EGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888.
Secondary IDs GO:0005023
GONUTS GO:0005006 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact EGFR
exact TGF-alpha receptor activity
exact transforming growth factor-alpha receptor activity
exact epidermal growth factor receptor activity
exact EGF receptor activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005006:
Relationship To GO:0005006 Child Term Child Term Name
Negatively regulates GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
Regulates GO:0007176 regulation of epidermal growth factor-activated receptor activity
Is a GO:0008313 gurken-activated receptor activity
Positively regulates GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
Has part GO:0048408 epidermal growth factor binding

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0005006. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0005006 based on the entire annotation set Co-occurrence statistics for GO:0005006 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-08-18 Added DEFINITION Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
2011-08-18 Updated TERM epidermal growth factor-activated receptor activity
2011-08-18 Added SYNONYM epidermal growth factor receptor activity
2011-08-18 Deleted DEFINITION Combining with an epidermal growth factor to initiate a change in cell activity.
2010-06-15 Added RELATION part of GO:0007173 (epidermal growth factor receptor signaling pathway)
2010-06-14 Deleted RELATION part of GO:0007173 (epidermal growth factor receptor signaling pathway)
2010-06-09 Updated TERM epidermal growth factor receptor activity
2010-06-08 Added RELATION part of GO:0007173 (epidermal growth factor receptor signaling pathway)
2010-06-08 Updated TERM epidermal growth factor receptor activity
2008-05-13 Added DEFINITION Combining with an epidermal growth factor to initiate a change in cell activity.
2008-05-12 Deleted DEFINITION Combining with an epidermal growth factor to initiate a change in cell activity.
2008-04-01 Updated RELATION is a GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2007-08-09 Added SYNONYM EGF receptor activity
2007-08-09 Added SYNONYM EGFR
2007-08-09 Added SYNONYM TGF-alpha receptor activity
2007-08-09 Added SYNONYM transforming growth factor-alpha receptor activity
2007-08-09 Deleted SYNONYM EGF receptor activity
2007-08-09 Deleted SYNONYM EGFR
2007-08-09 Deleted SYNONYM TGF-alpha receptor activity
2007-08-09 Deleted SYNONYM transforming growth factor-alpha receptor activity
2005-03-22 Updated DEFINITION Combining with an epidermal growth factor to initiate a change in cell activity.
2004-05-28 Added DEFINITION Combining with an epidermal growth factor, to initiate a change in cell activity.
2004-04-19 Added SYNONYM EGF receptor activity
2004-04-19 Added SYNONYM EGFR
2004-04-16 Deleted SYNONYM EGF receptor activity
2004-04-16 Deleted SYNONYM EGFR
2004-02-12 Added SYNONYM EGF receptor activity
2003-11-26 Added SECONDARY GO:0005023 (transforming growth factor-alpha receptor activity)
2003-11-26 Added SYNONYM TGF-alpha receptor activity
2003-11-26 Added SYNONYM transforming growth factor-alpha receptor activity
2003-03-19 Updated TERM epidermal growth factor receptor activity
2002-02-06 Updated TERM epidermal growth factor receptor
2001-04-03 Updated TERM epidermal growth factor receptor
2001-03-30 Added SYNONYM EGFR
2001-03-30 Added TERM epidermal growth factor receptor

Term

Timestamp Action Category Detail
2011-08-18 Updated TERM epidermal growth factor-activated receptor activity
2010-06-09 Updated TERM epidermal growth factor receptor activity
2010-06-08 Updated TERM epidermal growth factor receptor activity
2003-03-19 Updated TERM epidermal growth factor receptor activity
2002-02-06 Updated TERM epidermal growth factor receptor
2001-04-03 Updated TERM epidermal growth factor receptor
2001-03-30 Added TERM epidermal growth factor receptor

Definition/synonyms

Timestamp Action Category Detail
2011-08-18 Added DEFINITION Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
2011-08-18 Added SYNONYM epidermal growth factor receptor activity
2011-08-18 Deleted DEFINITION Combining with an epidermal growth factor to initiate a change in cell activity.
2008-05-13 Added DEFINITION Combining with an epidermal growth factor to initiate a change in cell activity.
2008-05-12 Deleted DEFINITION Combining with an epidermal growth factor to initiate a change in cell activity.
2007-08-09 Added SYNONYM EGF receptor activity
2007-08-09 Added SYNONYM EGFR
2007-08-09 Added SYNONYM TGF-alpha receptor activity
2007-08-09 Added SYNONYM transforming growth factor-alpha receptor activity
2007-08-09 Deleted SYNONYM EGF receptor activity
2007-08-09 Deleted SYNONYM EGFR
2007-08-09 Deleted SYNONYM TGF-alpha receptor activity
2007-08-09 Deleted SYNONYM transforming growth factor-alpha receptor activity
2005-03-22 Updated DEFINITION Combining with an epidermal growth factor to initiate a change in cell activity.
2004-05-28 Added DEFINITION Combining with an epidermal growth factor, to initiate a change in cell activity.
2004-04-19 Added SYNONYM EGF receptor activity
2004-04-19 Added SYNONYM EGFR
2004-04-16 Deleted SYNONYM EGF receptor activity
2004-04-16 Deleted SYNONYM EGFR
2004-02-12 Added SYNONYM EGF receptor activity
2003-11-26 Added SYNONYM TGF-alpha receptor activity
2003-11-26 Added SYNONYM transforming growth factor-alpha receptor activity
2001-03-30 Added SYNONYM EGFR

Relationships

Timestamp Action Category Detail
2010-06-15 Added RELATION part of GO:0007173 (epidermal growth factor receptor signaling pathway)
2010-06-14 Deleted RELATION part of GO:0007173 (epidermal growth factor receptor signaling pathway)
2010-06-08 Added RELATION part of GO:0007173 (epidermal growth factor receptor signaling pathway)
2008-04-01 Updated RELATION is a GO:0004714 (transmembrane receptor protein tyrosine kinase activity)

Other

Timestamp Action Category Detail
2003-11-26 Added SECONDARY GO:0005023 (transforming growth factor-alpha receptor activity)
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