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GO:0004950 chemokine receptor activity

Term Information

ID GO:0004950
Name chemokine receptor activity
Ontology Molecular Function
Definition Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
PMID:12183377 PMID:8662823
GONUTS GO:0004950 Wiki Page
Acknowledgements This term was created by the GO Consortium with support from BHF logo

Cross-references

Database ID
InterPro IPR000355
InterPro IPR005393

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004950:
Relationship To GO:0004950 Child Term Child Term Name
Is a GO:0016493 C-C chemokine receptor activity
Is a GO:0016494 C-X-C chemokine receptor activity
Is a GO:0016495 C-X3-C chemokine receptor activity
Has part GO:0019956 chemokine binding

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004950. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004950 based on the entire annotation set Co-occurrence statistics for GO:0004950 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-01-18 Added DEFINITION Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
2014-01-18 Deleted DEFINITION Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are small chemoattractant molecules normally used to stimulate leukocytes.
2012-03-24 Added RELATION part of GO:0070098 (chemokine-mediated signaling pathway)
2012-02-05 Deleted DEFINITION Combining with chemokines, small chemoattractant molecules normally used to stimulate leukocytes, to initiate a change in cell activity.
2012-02-05 Added DEFINITION Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are small chemoattractant molecules normally used to stimulate leukocytes.
2011-10-28 Added RELATION is a GO:0004896 (cytokine receptor activity)
2011-10-28 Deleted RELATION is a GO:0019956 (chemokine binding)
2008-05-13 Added DEFINITION Combining with chemokines, small chemoattractant molecules normally used to stimulate leukocytes, to initiate a change in cell activity.
2008-05-12 Deleted DEFINITION Combining with chemokines, small chemoattractant molecules normally used to stimulate leukocytes, to initiate a change in cell activity.
2008-04-01 Updated RELATION is a GO:0019956 (chemokine binding)
2008-04-01 Updated RELATION is a GO:0001637 (G-protein coupled chemoattractant receptor activity)
2004-01-03 Updated DEFINITION Combining with chemokines, small chemoattractant molecules normally used to stimulate leukocytes, to initiate a change in cell activity.
2003-05-08 Updated DEFINITION The function of combining with chemokines, small chemoattractant molecules normally used to stimulate leukocytes, to initiate a change in cell function.
2003-03-19 Updated TERM chemokine receptor activity
2002-11-27 Added DEFINITION A G-protein coupled receptor that binds small chemoattractant molecules normally used to stimulate leukocytes.
2002-02-06 Updated TERM chemokine receptor
2001-04-03 Updated TERM chemokine receptor
2001-03-30 Added TERM chemokine receptor

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM chemokine receptor activity
2002-02-06 Updated TERM chemokine receptor
2001-04-03 Updated TERM chemokine receptor
2001-03-30 Added TERM chemokine receptor

Definition/synonyms

Timestamp Action Category Detail
2014-01-18 Added DEFINITION Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
2014-01-18 Deleted DEFINITION Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are small chemoattractant molecules normally used to stimulate leukocytes.
2012-02-05 Deleted DEFINITION Combining with chemokines, small chemoattractant molecules normally used to stimulate leukocytes, to initiate a change in cell activity.
2012-02-05 Added DEFINITION Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are small chemoattractant molecules normally used to stimulate leukocytes.
2008-05-13 Added DEFINITION Combining with chemokines, small chemoattractant molecules normally used to stimulate leukocytes, to initiate a change in cell activity.
2008-05-12 Deleted DEFINITION Combining with chemokines, small chemoattractant molecules normally used to stimulate leukocytes, to initiate a change in cell activity.
2004-01-03 Updated DEFINITION Combining with chemokines, small chemoattractant molecules normally used to stimulate leukocytes, to initiate a change in cell activity.
2003-05-08 Updated DEFINITION The function of combining with chemokines, small chemoattractant molecules normally used to stimulate leukocytes, to initiate a change in cell function.
2002-11-27 Added DEFINITION A G-protein coupled receptor that binds small chemoattractant molecules normally used to stimulate leukocytes.

Relationships

Timestamp Action Category Detail
2012-03-24 Added RELATION part of GO:0070098 (chemokine-mediated signaling pathway)
2011-10-28 Added RELATION is a GO:0004896 (cytokine receptor activity)
2011-10-28 Deleted RELATION is a GO:0019956 (chemokine binding)
2008-04-01 Updated RELATION is a GO:0019956 (chemokine binding)
2008-04-01 Updated RELATION is a GO:0001637 (G-protein coupled chemoattractant receptor activity)
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