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GO:0004930 G-protein coupled receptor activity

A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.

Term Information

ID GO:0004930
Name G-protein coupled receptor activity
Ontology Molecular Function
Definition A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
Comment

Synonyms

Type Synonym
exact orphan G-protein coupled receptor activity
exact orphan G protein coupled receptor activity
exact ligand-dependent GPCR activity
exact orphan GPCR activity
exact GPCR activity
exact G protein linked receptor activity
exact G-protein coupled receptor activity, unknown ligand
exact G-protein linked receptor activity
exact G-protein-coupled receptor activity
exact G protein coupled receptor activity

Cross-references associated with this term:

Database ID
INTERPRO IPR003334
INTERPRO IPR011500
INTERPRO IPR003904
INTERPRO IPR000848
INTERPRO IPR000832
INTERPRO IPR000820
INTERPRO IPR017978
INTERPRO IPR015531
INTERPRO IPR002258
INTERPRO IPR002276
INTERPRO IPR000984
INTERPRO IPR001151
INTERPRO IPR000723
INTERPRO IPR001879
INTERPRO IPR017979
INTERPRO IPR003056
INTERPRO IPR003053
INTERPRO IPR003052
INTERPRO IPR003051
INTERPRO IPR000935
INTERPRO IPR017983
INTERPRO IPR000068
INTERPRO IPR003288
INTERPRO IPR003289
INTERPRO IPR000337
INTERPRO IPR001740
INTERPRO IPR007960
INTERPRO IPR001793
INTERPRO IPR010596
INTERPRO IPR008112
INTERPRO IPR002144

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Ancestor Chart

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Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0003674 molecular_function
GO:0060089 molecular transducer activity
GO:0004871 signal transducer activity
GO:0004872 receptor activity
GO:0004888 transmembrane receptor activity
GO:0004930 G-protein coupled receptor activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
I GO:0001647 G-protein coupled cytokinin receptor activity
I GO:0001622 super conserved receptor expressed in brain receptor activity
I GO:0001623 Mas proto-oncogene receptor activity
I GO:0001624 RDC1 receptor activity
I GO:0001625 Epstein-Barr Virus-induced receptor activity
I GO:0001626 nociceptin/orphanin-FQ receptor activity
I GO:0001628 gastropyloric receptor activity
I GO:0001640 adenylate cyclase inhibiting metabotropic glutamate receptor activity
I GO:0001634 pituitary adenylate cyclase-activating polypeptide receptor activity
I GO:0001635 calcitonin gene-related polypeptide receptor activity
I GO:0004953 icosanoid receptor activity
I GO:0004967 glucagon receptor activity
I GO:0004974 leukotriene receptor activity
I GO:0004984 olfactory receptor activity
I GO:0004991 parathyroid hormone receptor activity
I GO:0004992 platelet activating factor receptor activity
I GO:0004948 calcitonin receptor activity
I GO:0004949 cannabinoid receptor activity
I GO:0042654 ecdysis-triggering hormone receptor activity
I GO:0004997 thyrotropin-releasing hormone receptor activity
I GO:0004999 vasoactive intestinal polypeptide receptor activity
I GO:0008020 G-protein coupled photoreceptor activity
I GO:0008227 G-protein coupled amine receptor activity
I GO:0008502 melatonin receptor activity
I GO:0008527 taste receptor activity
I GO:0008528 peptide receptor activity, G-protein coupled
I GO:0015055 secretin receptor activity
I GO:0015056 corticotrophin-releasing factor receptor activity
I GO:0016500 protein-hormone receptor activity
I GO:0016519 gastric inhibitory peptide receptor activity
I GO:0016520 growth hormone-releasing hormone receptor activity
I GO:0016527 brain-specific angiogenesis inhibitor activity
I GO:0045125 bioactive lipid receptor activity
I GO:0001621 platelet ADP receptor activity
I GO:0001608 nucleotide receptor activity, G-protein coupled
I GO:0001616 growth hormone secretagogue receptor activity
I GO:0016503 pheromone receptor activity
I GO:0070553 nicotinic acid receptor activity

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

This display shows those GO terms which have been annotated to the same proteins as this term.
Terms may have been co-annotated either by electronic (IEA) or manual annotation methods. Users can decide which evidence code type should be used in the calculation of the co-occurence statistics.
Click on the 'Update' button to run the co-occurence calculation
IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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