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GO:0004888 transmembrane signaling receptor activity

Term Information

ID GO:0004888
Name transmembrane signaling receptor activity
Ontology Molecular Function
Definition Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
Comment The definition allows for intracellular ligands for cases of transmission across an intracellular membrane, e.g. IP3 triggered release of Ca2+ from intracellular stores.
Secondary IDs GO:0004926
GONUTS GO:0004888 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow non-G-protein coupled 7TM receptor activity
narrow non-G-protein-coupled 7TM receptor activity
narrow non G protein coupled 7TM receptor activity
exact transmembrane signalling receptor activity
broad transmembrane receptor activity

Cross-references

Database ID
InterPro IPR000609
InterPro IPR002184
InterPro IPR003110
InterPro IPR003122
InterPro IPR004075
InterPro IPR008063
InterPro IPR009167
InterPro IPR015149
InterPro IPR015485
InterPro IPR016316
InterPro IPR017241
InterPro IPR017981
InterPro IPR020416
InterPro IPR026880
InterPro IPR027168
InterPro IPR027173
InterPro IPR027176
InterPro IPR027181
InterPro IPR027182
InterPro IPR027187
InterPro IPR027190
InterPro IPR027194
InterPro IPR027195
InterPro IPR027202
InterPro IPR032848
InterPro IPR033549

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0004927 obsolete sevenless receptor activity CONSIDER GO:0004888
GO:0045233 obsolete natural killer cell receptor activity CONSIDER GO:0004888

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004888:
Relationship To GO:0004888 Child Term Child Term Name
Is a GO:0015464 acetylcholine receptor activity
Is a GO:0008158 hedgehog receptor activity
Is a GO:0016917 GABA receptor activity
Is a GO:0042813 Wnt-activated receptor activity
Is a GO:0001847 opsonin receptor activity
Is a GO:0016502 nucleotide receptor activity
Is a GO:0017154 semaphorin receptor activity
Is a GO:0009884 cytokinin receptor activity
Is a GO:0004875 complement receptor activity
Is a GO:0030369 ICAM-3 receptor activity
Is a GO:0008046 axon guidance receptor activity
Is a GO:0008066 glutamate receptor activity
Is a GO:0008281 sulfonylurea receptor activity
Is a GO:0019198 transmembrane receptor protein phosphatase activity
Is a GO:0019199 transmembrane receptor protein kinase activity
Is a GO:0016524 latrotoxin receptor activity
Is a GO:0004896 cytokine receptor activity
Is a GO:0004930 G-protein coupled receptor activity
Is a GO:0005034 osmosensor activity
Is a GO:0005035 death receptor activity
Is a GO:0005056 tiggrin receptor activity
Is a GO:0030379 neurotensin receptor activity, non-G-protein coupled
Is a GO:0019763 immunoglobulin receptor activity
Is a GO:0001571 non-tyrosine kinase fibroblast growth factor receptor activity
Is a GO:0035586 purinergic receptor activity
Is a GO:0032393 MHC class I receptor activity
Is a GO:0032394 MHC class Ib receptor activity
Is a GO:0032395 MHC class II receptor activity
Is a GO:0005042 netrin receptor activity
Is a GO:0004984 olfactory receptor activity
Is a GO:0038064 collagen receptor activity
Is a GO:0034188 apolipoprotein A-I receptor activity
Is a GO:0038025 reelin receptor activity
Is a GO:0038131 neuregulin receptor activity
Capable of GO:1990779 glycoprotein Ib-IX-V complex
Is a GO:0022835 transmitter-gated channel activity
Is a GO:0099604 ligand-gated calcium channel activity
Is a GO:0008527 taste receptor activity
Is a GO:0099589 serotonin receptor activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
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Date
Assigned By
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Name
Synonym
Type
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004888. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004888 based on the entire annotation set Co-occurrence statistics for GO:0004888 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2016-03-02 Added DEFINITION Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
2016-03-02 Deleted DEFINITION Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2016-03-02 Added RELATION is a GO:0099600 (transmembrane receptor activity)
2016-03-02 Added RELATION part of GO:0007165 (signal transduction)
2012-04-14 Added SYNONYM transmembrane signalling receptor activity
2011-08-04 Updated TERM transmembrane signaling receptor activity
2011-08-04 Added SYNONYM transmembrane receptor activity
2011-08-04 Added RELATION is a GO:0038023 (signaling receptor activity)
2011-08-04 Deleted RELATION is a GO:0004872 (receptor activity)
2011-01-30 Added DEFINITION Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2011-01-30 Deleted DEFINITION Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
2010-10-07 Added SECONDARY GO:0004926 (non-G-protein coupled 7TM receptor activity)
2010-10-07 Added SYNONYM non G protein coupled 7TM receptor activity
2010-10-07 Added SYNONYM non-G-protein coupled 7TM receptor activity
2010-10-07 Added SYNONYM non-G-protein-coupled 7TM receptor activity
2008-05-13 Added DEFINITION Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
2008-05-12 Deleted DEFINITION Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
2008-04-01 Updated RELATION is a GO:0004872 (receptor activity)
2005-06-30 Added DEFINITION Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
2003-03-19 Updated TERM transmembrane receptor activity
2002-02-06 Updated TERM transmembrane receptor
2001-04-03 Updated TERM transmembrane receptor
2001-03-30 Added TERM transmembrane receptor

Term

Timestamp Action Category Detail
2011-08-04 Updated TERM transmembrane signaling receptor activity
2003-03-19 Updated TERM transmembrane receptor activity
2002-02-06 Updated TERM transmembrane receptor
2001-04-03 Updated TERM transmembrane receptor
2001-03-30 Added TERM transmembrane receptor

Definition/synonyms

Timestamp Action Category Detail
2016-03-02 Added DEFINITION Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
2016-03-02 Deleted DEFINITION Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2012-04-14 Added SYNONYM transmembrane signalling receptor activity
2011-08-04 Added SYNONYM transmembrane receptor activity
2011-01-30 Added DEFINITION Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2011-01-30 Deleted DEFINITION Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
2010-10-07 Added SYNONYM non G protein coupled 7TM receptor activity
2010-10-07 Added SYNONYM non-G-protein coupled 7TM receptor activity
2010-10-07 Added SYNONYM non-G-protein-coupled 7TM receptor activity
2008-05-13 Added DEFINITION Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
2008-05-12 Deleted DEFINITION Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
2005-06-30 Added DEFINITION Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.

Relationships

Timestamp Action Category Detail
2016-03-02 Added RELATION is a GO:0099600 (transmembrane receptor activity)
2016-03-02 Added RELATION part of GO:0007165 (signal transduction)
2011-08-04 Added RELATION is a GO:0038023 (signaling receptor activity)
2011-08-04 Deleted RELATION is a GO:0004872 (receptor activity)
2008-04-01 Updated RELATION is a GO:0004872 (receptor activity)

Other

Timestamp Action Category Detail
2010-10-07 Added SECONDARY GO:0004926 (non-G-protein coupled 7TM receptor activity)
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