spacer

GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity

Term Information

ID GO:0004879
Name ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
Ontology Molecular Function
Definition Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
Comment GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA. When the nuclear receptor functions by binding to other transcription factors or transcription factor complexes, consider instead annotating to 'ligand-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038049'.
GONUTS GO:0004879 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related ligand-dependent transcription factor activity
narrow nuclear hormone receptor
related ligand-dependent nuclear receptor activity
related nuclear receptor activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to transcription factor activitiesLink

Cross-references

Database ID
InterPro IPR003068
InterPro IPR003070
InterPro IPR003071
InterPro IPR003072
InterPro IPR003073
InterPro IPR003074
InterPro IPR003075
InterPro IPR003076
InterPro IPR003077
InterPro IPR003079

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0003706 ligand-regulated transcription factor activity CONSIDER GO:0004879
GO:0023055 signal initiation by peptide hormone CONSIDER GO:0004879
GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor CONSIDER GO:0004879
GO:0072500 negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor CONSIDER GO:0004879
GO:2000190 negative regulation of regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor CONSIDER GO:0004879

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004879:
Relationship To GO:0004879 Child Term Child Term Name
Is a GO:0003708 retinoic acid receptor activity
Is a GO:0004880 juvenile hormone receptor activity
Is a GO:0004887 thyroid hormone receptor activity
Is a GO:0008434 calcitriol receptor activity
Is a GO:0004882 androgen receptor activity
Is a GO:0004884 ecdysteroid hormone receptor activity
Is a GO:0017082 mineralocorticoid receptor activity
Is a GO:0038050 glucocorticoid-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
Is a GO:0038052 estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004879. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004879 based on the entire annotation set Co-occurrence statistics for GO:0004879 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-10-23 Added RELATION is a GO:0098531 (direct ligand regulated sequence-specific DNA binding transcription factor activity)
2013-10-23 Deleted RELATION is a GO:0038023 (signaling receptor activity)
2011-11-30 Added RELATION is a GO:0000981 (sequence-specific DNA binding RNA polymerase II transcription factor activity)
2011-11-30 Added SYNONYM ligand-dependent nuclear receptor activity
2011-11-30 Added SYNONYM ligand-dependent transcription factor activity
2011-11-30 Added SYNONYM nuclear receptor activity
2011-11-30 Deleted DEFINITION A ligand-dependent receptor found in the nucleus of the cell.
2011-11-30 Added DEFINITION Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
2011-11-30 Updated TERM ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
2011-08-04 Added RELATION is a GO:0038023 (signaling receptor activity)
2011-08-04 Deleted RELATION is a GO:0004872 (receptor activity)
2011-06-12 Added RELATION part of GO:0030522 (intracellular receptor signaling pathway)
2008-05-13 Added DEFINITION A ligand-dependent receptor found in the nucleus of the cell.
2008-05-12 Deleted DEFINITION A ligand-dependent receptor found in the nucleus of the cell.
2008-04-01 Updated RELATION is a GO:0004872 (receptor activity)
2007-08-09 Added SYNONYM nuclear hormone receptor
2007-08-09 Deleted SYNONYM nuclear hormone receptor
2004-04-19 Added SYNONYM nuclear hormone receptor
2004-04-16 Deleted SYNONYM nuclear hormone receptor
2004-04-01 Updated DEFINITION A ligand-dependent receptor found in the nucleus of the cell.
2003-05-14 Added DEFINITION A ligand-dependent receptor found in the the nucleus of the cell.
2003-03-19 Updated TERM ligand-dependent nuclear receptor activity
2002-02-06 Updated TERM ligand-dependent nuclear receptor
2001-04-03 Updated TERM ligand-dependent nuclear receptor
2001-03-30 Added SYNONYM nuclear hormone receptor
2001-03-30 Added TERM ligand-dependent nuclear receptor

Term

Timestamp Action Category Detail
2011-11-30 Updated TERM ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
2003-03-19 Updated TERM ligand-dependent nuclear receptor activity
2002-02-06 Updated TERM ligand-dependent nuclear receptor
2001-04-03 Updated TERM ligand-dependent nuclear receptor
2001-03-30 Added TERM ligand-dependent nuclear receptor

Definition/synonyms

Timestamp Action Category Detail
2011-11-30 Added SYNONYM ligand-dependent nuclear receptor activity
2011-11-30 Added SYNONYM ligand-dependent transcription factor activity
2011-11-30 Added SYNONYM nuclear receptor activity
2011-11-30 Deleted DEFINITION A ligand-dependent receptor found in the nucleus of the cell.
2011-11-30 Added DEFINITION Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
2008-05-13 Added DEFINITION A ligand-dependent receptor found in the nucleus of the cell.
2008-05-12 Deleted DEFINITION A ligand-dependent receptor found in the nucleus of the cell.
2007-08-09 Added SYNONYM nuclear hormone receptor
2007-08-09 Deleted SYNONYM nuclear hormone receptor
2004-04-19 Added SYNONYM nuclear hormone receptor
2004-04-16 Deleted SYNONYM nuclear hormone receptor
2004-04-01 Updated DEFINITION A ligand-dependent receptor found in the nucleus of the cell.
2003-05-14 Added DEFINITION A ligand-dependent receptor found in the the nucleus of the cell.
2001-03-30 Added SYNONYM nuclear hormone receptor

Relationships

Timestamp Action Category Detail
2013-10-23 Added RELATION is a GO:0098531 (direct ligand regulated sequence-specific DNA binding transcription factor activity)
2013-10-23 Deleted RELATION is a GO:0038023 (signaling receptor activity)
2011-11-30 Added RELATION is a GO:0000981 (sequence-specific DNA binding RNA polymerase II transcription factor activity)
2011-08-04 Added RELATION is a GO:0038023 (signaling receptor activity)
2011-08-04 Deleted RELATION is a GO:0004872 (receptor activity)
2011-06-12 Added RELATION part of GO:0030522 (intracellular receptor signaling pathway)
2008-04-01 Updated RELATION is a GO:0004872 (receptor activity)
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
20ms