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GO:0004867 serine-type endopeptidase inhibitor activity

Term Information

ID GO:0004867
Name serine-type endopeptidase inhibitor activity
Ontology Molecular Function
Definition Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.
GONUTS GO:0004867 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact serine protease inhibitor activity
narrow serpin activity
exact serine proteinase inhibitor activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
InterPro IPR000240
InterPro IPR000295
InterPro IPR000429
InterPro IPR000691
InterPro IPR000737
InterPro IPR000864
InterPro IPR000877
InterPro IPR001239
InterPro IPR002223
InterPro IPR003465
InterPro IPR004094
InterPro IPR006105
InterPro IPR006106
InterPro IPR008086
InterPro IPR010600
InterPro IPR015553
InterPro IPR015555
InterPro IPR015556
InterPro IPR015557
InterPro IPR020054
InterPro IPR023549
InterPro IPR024793
UniProtKB-KW Serine protease inhibitor

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0004868 serpin CONSIDER GO:0004867
GO:0030304 trypsin inhibitor activity REPLACEDBY GO:0004867
GO:0030568 plasmin inhibitor activity REPLACEDBY GO:0004867
GO:0030569 chymotrypsin inhibitor activity REPLACEDBY GO:0004867

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004867:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO ID
Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004867. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004867 based on the entire annotation set Co-occurrence statistics for GO:0004867 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-06-15 Added RELATION negatively regulates GO:0004252 (serine-type endopeptidase activity)
2010-06-14 Deleted RELATION negatively regulates GO:0004252 (serine-type endopeptidase activity)
2010-06-08 Added RELATION negatively regulates GO:0004252 (serine-type endopeptidase activity)
2009-02-25 Deleted RELATION negatively regulates GO:0004252 (serine-type endopeptidase activity)
2009-02-22 Added RELATION negatively regulates GO:0004252 (serine-type endopeptidase activity)
2008-08-18 Added DEFINITION Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.
2008-08-18 Deleted DEFINITION Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active center of the enzyme.
2008-05-13 Added DEFINITION Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active center of the enzyme.
2008-05-12 Deleted DEFINITION Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active center of the enzyme.
2008-04-01 Updated RELATION is a GO:0004866 (endopeptidase inhibitor activity)
2007-09-26 Deleted SYNONYM serpin
2007-09-26 Deleted SYNONYM serpin activity
2007-09-26 Added SYNONYM serpin activity
2007-08-09 Added SYNONYM serine protease inhibitor activity
2007-08-09 Added SYNONYM serine proteinase inhibitor activity
2007-08-09 Added SYNONYM serpin
2007-08-09 Added SYNONYM serpin activity
2007-08-09 Deleted SYNONYM serine protease inhibitor activity
2007-08-09 Deleted SYNONYM serine proteinase inhibitor activity
2007-08-09 Deleted SYNONYM serpin
2007-08-09 Deleted SYNONYM serpin activity
2005-08-10 Added SYNONYM serpin
2004-04-19 Added SYNONYM serine protease inhibitor activity
2004-04-19 Added SYNONYM serine proteinase inhibitor activity
2004-04-19 Added SYNONYM serpin activity
2004-04-16 Deleted SYNONYM serine protease inhibitor activity
2004-04-16 Deleted SYNONYM serine proteinase inhibitor activity
2004-04-16 Deleted SYNONYM serpin activity
2004-01-08 Added SYNONYM serine proteinase inhibitor activity
2004-01-08 Added SYNONYM serpin activity
2004-01-08 Deleted SYNONYM serine proteinase inhibitor
2004-01-08 Deleted SYNONYM serpin
2004-01-08 Updated TERM serine-type endopeptidase inhibitor activity
2004-01-08 Added DEFINITION Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active center of the enzyme.
2004-01-08 Added SYNONYM serine protease inhibitor activity
2003-03-19 Updated TERM serine protease inhibitor activity
2003-03-19 Added SYNONYM serpin
2002-02-14 Added SYNONYM serine proteinase inhibitor
2002-02-06 Updated TERM serine protease inhibitor
2001-04-03 Updated TERM serine protease inhibitor
2001-03-30 Added TERM serine protease inhibitor

Term

Timestamp Action Category Detail
2004-01-08 Updated TERM serine-type endopeptidase inhibitor activity
2003-03-19 Updated TERM serine protease inhibitor activity
2002-02-06 Updated TERM serine protease inhibitor
2001-04-03 Updated TERM serine protease inhibitor
2001-03-30 Added TERM serine protease inhibitor

Definition/synonyms

Timestamp Action Category Detail
2008-08-18 Added DEFINITION Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.
2008-08-18 Deleted DEFINITION Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active center of the enzyme.
2008-05-13 Added DEFINITION Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active center of the enzyme.
2008-05-12 Deleted DEFINITION Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active center of the enzyme.
2007-09-26 Deleted SYNONYM serpin
2007-09-26 Deleted SYNONYM serpin activity
2007-09-26 Added SYNONYM serpin activity
2007-08-09 Added SYNONYM serine protease inhibitor activity
2007-08-09 Added SYNONYM serine proteinase inhibitor activity
2007-08-09 Added SYNONYM serpin
2007-08-09 Added SYNONYM serpin activity
2007-08-09 Deleted SYNONYM serine protease inhibitor activity
2007-08-09 Deleted SYNONYM serine proteinase inhibitor activity
2007-08-09 Deleted SYNONYM serpin
2007-08-09 Deleted SYNONYM serpin activity
2005-08-10 Added SYNONYM serpin
2004-04-19 Added SYNONYM serine protease inhibitor activity
2004-04-19 Added SYNONYM serine proteinase inhibitor activity
2004-04-19 Added SYNONYM serpin activity
2004-04-16 Deleted SYNONYM serine protease inhibitor activity
2004-04-16 Deleted SYNONYM serine proteinase inhibitor activity
2004-04-16 Deleted SYNONYM serpin activity
2004-01-08 Added SYNONYM serine proteinase inhibitor activity
2004-01-08 Added SYNONYM serpin activity
2004-01-08 Deleted SYNONYM serine proteinase inhibitor
2004-01-08 Deleted SYNONYM serpin
2004-01-08 Added DEFINITION Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active center of the enzyme.
2004-01-08 Added SYNONYM serine protease inhibitor activity
2003-03-19 Added SYNONYM serpin
2002-02-14 Added SYNONYM serine proteinase inhibitor

Relationships

Timestamp Action Category Detail
2010-06-15 Added RELATION negatively regulates GO:0004252 (serine-type endopeptidase activity)
2010-06-14 Deleted RELATION negatively regulates GO:0004252 (serine-type endopeptidase activity)
2010-06-08 Added RELATION negatively regulates GO:0004252 (serine-type endopeptidase activity)
2009-02-25 Deleted RELATION negatively regulates GO:0004252 (serine-type endopeptidase activity)
2009-02-22 Added RELATION negatively regulates GO:0004252 (serine-type endopeptidase activity)
2008-04-01 Updated RELATION is a GO:0004866 (endopeptidase inhibitor activity)
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