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GO:0004867 serine-type endopeptidase inhibitor activity

Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

Term Information

ID GO:0004867
Name serine-type endopeptidase inhibitor activity
Ontology Molecular Function
Definition Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.
Comment

Synonyms

Type Synonym
exact serine protease inhibitor activity
exact serine proteinase inhibitor activity
narrow serpin activity

Cross-references associated with this term:

Database ID
INTERPRO IPR018112
INTERPRO IPR001239
INTERPRO IPR002223
INTERPRO IPR015553
INTERPRO IPR015555
INTERPRO IPR015556
INTERPRO IPR015557
INTERPRO IPR000227
INTERPRO IPR000240
INTERPRO IPR000295
INTERPRO IPR000215
INTERPRO IPR003465
INTERPRO IPR004094
INTERPRO IPR008086
INTERPRO IPR000691
INTERPRO IPR000429
INTERPRO IPR020054
INTERPRO IPR000877
INTERPRO IPR010600
INTERPRO IPR006105
INTERPRO IPR006106
INTERPRO IPR000737
INTERPRO IPR000864

This term can be used instead of these obsolete terms:

GO:0030568 plasmin inhibitor activity (replaced_by GO:0004867)
GO:0030304 trypsin inhibitor activity (replaced_by GO:0004867)
GO:0030569 chymotrypsin inhibitor activity (replaced_by GO:0004867)
GO:0004868 serpin (consider GO:0004867)

Web service: term information

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Ancestor Chart

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Ancestor Table

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GO:0003674 molecular_function
GO:0030234 enzyme regulator activity
GO:0004857 enzyme inhibitor activity
GO:0030414 peptidase inhibitor activity
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
Term has no children

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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Terms may have been co-annotated either by electronic (IEA) or manual annotation methods. Users can decide which evidence code type should be used in the calculation of the co-occurence statistics.
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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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