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GO:0004866 endopeptidase inhibitor activity

Term Information

ID GO:0004866
Name endopeptidase inhibitor activity
Ontology Molecular Function
Definition Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
GONUTS GO:0004866 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
broad proteinase inhibitor
related alpha-2 macroglobulin
exact endoproteinase inhibitor

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
InterPro IPR001599
InterPro IPR001713
InterPro IPR002160
InterPro IPR002890
InterPro IPR003086
InterPro IPR010832
InterPro IPR011052
InterPro IPR016085
InterPro IPR029712

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0008539 proteasome inhibitor activity CONSIDER GO:0004866
GO:0016975 alpha-2 macroglobulin REPLACEDBY GO:0004866

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004866:
Relationship To GO:0004866 Child Term Child Term Name
Is a GO:0008191 metalloendopeptidase inhibitor activity
Is a GO:0004867 serine-type endopeptidase inhibitor activity
Is a GO:0004869 cysteine-type endopeptidase inhibitor activity
Is a GO:0019828 aspartic-type endopeptidase inhibitor activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO ID
Original GO Term Name
Evidence
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004866. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004866 based on the entire annotation set Co-occurrence statistics for GO:0004866 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-06-15 Added RELATION part of GO:0010951 (negative regulation of endopeptidase activity)
2010-06-15 Added RELATION negatively regulates GO:0004175 (endopeptidase activity)
2010-06-14 Deleted RELATION part of GO:0010951 (negative regulation of endopeptidase activity)
2010-06-14 Deleted RELATION negatively regulates GO:0004175 (endopeptidase activity)
2010-06-08 Added RELATION part of GO:0010951 (negative regulation of endopeptidase activity)
2010-06-08 Added RELATION negatively regulates GO:0004175 (endopeptidase activity)
2010-05-19 Added RELATION is a GO:0061135 (endopeptidase regulator activity)
2009-02-25 Deleted RELATION negatively regulates GO:0004175 (endopeptidase activity)
2009-02-22 Added RELATION negatively regulates GO:0004175 (endopeptidase activity)
2008-08-18 Deleted DEFINITION Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide linkages in polypeptides.
2008-08-18 Added DEFINITION Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
2008-05-13 Added DEFINITION Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide linkages in polypeptides.
2008-05-12 Deleted DEFINITION Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide linkages in polypeptides.
2008-04-01 Updated RELATION is a GO:0030414 (peptidase inhibitor activity)
2007-08-09 Added SYNONYM alpha-2 macroglobulin
2007-08-09 Added SYNONYM endoproteinase inhibitor
2007-08-09 Added SYNONYM proteinase inhibitor
2007-08-09 Deleted SYNONYM alpha-2 macroglobulin
2007-08-09 Deleted SYNONYM endoproteinase inhibitor
2007-08-09 Deleted SYNONYM proteinase inhibitor
2005-08-10 Added SYNONYM alpha-2 macroglobulin
2004-04-19 Added SYNONYM endoproteinase inhibitor
2004-04-19 Added SYNONYM proteinase inhibitor
2004-04-16 Deleted SYNONYM endoproteinase inhibitor
2004-04-16 Deleted SYNONYM proteinase inhibitor
2004-01-08 Updated DEFINITION Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide linkages in polypeptides.
2003-04-09 Updated DEFINITION Stops, prevents or reduces the activity of any enzyme that hydrolyzes nonterminal peptide linkages in polypeptides.
2003-03-19 Updated TERM endopeptidase inhibitor activity
2002-11-27 Added DEFINITION Stops, prevents or decreases the activity of any enzyme that hydrolyzes nonterminal peptide linkages in polypeptides.
2002-02-14 Added SYNONYM proteinase inhibitor
2002-02-14 Updated TERM endopeptidase inhibitor
2002-02-14 Added SYNONYM endoproteinase inhibitor
2002-02-06 Updated TERM proteinase inhibitor
2001-04-03 Updated TERM proteinase inhibitor
2001-03-30 Added TERM proteinase inhibitor

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM endopeptidase inhibitor activity
2002-02-14 Updated TERM endopeptidase inhibitor
2002-02-06 Updated TERM proteinase inhibitor
2001-04-03 Updated TERM proteinase inhibitor
2001-03-30 Added TERM proteinase inhibitor

Definition/synonyms

Timestamp Action Category Detail
2008-08-18 Deleted DEFINITION Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide linkages in polypeptides.
2008-08-18 Added DEFINITION Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
2008-05-13 Added DEFINITION Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide linkages in polypeptides.
2008-05-12 Deleted DEFINITION Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide linkages in polypeptides.
2007-08-09 Added SYNONYM alpha-2 macroglobulin
2007-08-09 Added SYNONYM endoproteinase inhibitor
2007-08-09 Added SYNONYM proteinase inhibitor
2007-08-09 Deleted SYNONYM alpha-2 macroglobulin
2007-08-09 Deleted SYNONYM endoproteinase inhibitor
2007-08-09 Deleted SYNONYM proteinase inhibitor
2005-08-10 Added SYNONYM alpha-2 macroglobulin
2004-04-19 Added SYNONYM endoproteinase inhibitor
2004-04-19 Added SYNONYM proteinase inhibitor
2004-04-16 Deleted SYNONYM endoproteinase inhibitor
2004-04-16 Deleted SYNONYM proteinase inhibitor
2004-01-08 Updated DEFINITION Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide linkages in polypeptides.
2003-04-09 Updated DEFINITION Stops, prevents or reduces the activity of any enzyme that hydrolyzes nonterminal peptide linkages in polypeptides.
2002-11-27 Added DEFINITION Stops, prevents or decreases the activity of any enzyme that hydrolyzes nonterminal peptide linkages in polypeptides.
2002-02-14 Added SYNONYM proteinase inhibitor
2002-02-14 Added SYNONYM endoproteinase inhibitor

Relationships

Timestamp Action Category Detail
2010-06-15 Added RELATION part of GO:0010951 (negative regulation of endopeptidase activity)
2010-06-15 Added RELATION negatively regulates GO:0004175 (endopeptidase activity)
2010-06-14 Deleted RELATION part of GO:0010951 (negative regulation of endopeptidase activity)
2010-06-14 Deleted RELATION negatively regulates GO:0004175 (endopeptidase activity)
2010-06-08 Added RELATION part of GO:0010951 (negative regulation of endopeptidase activity)
2010-06-08 Added RELATION negatively regulates GO:0004175 (endopeptidase activity)
2010-05-19 Added RELATION is a GO:0061135 (endopeptidase regulator activity)
2009-02-25 Deleted RELATION negatively regulates GO:0004175 (endopeptidase activity)
2009-02-22 Added RELATION negatively regulates GO:0004175 (endopeptidase activity)
2008-04-01 Updated RELATION is a GO:0030414 (peptidase inhibitor activity)
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