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GO:0004848 ureidoglycolate hydrolase activity

Term Information

ID GO:0004848
Name ureidoglycolate hydrolase activity
Ontology Molecular Function
Definition Catalysis of the reaction: (S)-ureidoglycolate + H(2)O + 2 H(+) = CO(2) + glyoxylate + 2 NH(4)(+).
Comment Take care to annotate to the reaction, not simply the enzyme name. The name "ureidoglycolate hydrolase" has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The "ureidoglycolate hydrolase" listed in the Enzyme commission (EC) is a ureidoglycolate amidohydrolase, releasing ammonia, (EC 3.5.3.19, GO:0004848). The "ureidoglycolate hydrolase" characterized in PMID:3915539 (published prior to the EC designation of EC 3.5.3.19) is a ureidoglycolate lyase, releasing urea (EC 4.3.2.3, GO:0050385). The inappropriate labelling of ureidoglycolate lyase as EC 3.5.3.19 has caused much confusion in the literature (see PMID:24107613). Take care to correctly annotate based on the reaction products, rather than name.
GONUTS GO:0004848 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact (S)-ureidoglycolate amidohydrolase (decarboxylating)

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.5.3.19
InterPro IPR007247
InterPro IPR023525
InterPro IPR024060
KEGG R00469
MetaCyc UREIDOGLYCOLATE-HYDROLASE-RXN
RHEA 19812

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004848:
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Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004848. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004848 based on the entire annotation set Co-occurrence statistics for GO:0004848 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-10-11 Added DEFINITION Catalysis of the reaction: (S)-ureidoglycolate + H(2)O + 2 H(+) = CO(2) + glyoxylate + 2 NH(4)(+).
2010-10-11 Deleted DEFINITION Catalysis of the reaction: (-)-ureidoglycolate + H2O = glyoxylate + 2 NH3 + CO2.
2010-10-11 Added XREF RHEA:19812
2010-10-11 Added XREF KEGG:R00469
2008-05-13 Added DEFINITION Catalysis of the reaction: (-)-ureidoglycolate + H2O = glyoxylate + 2 NH3 + CO2.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: (-)-ureidoglycolate + H2O = glyoxylate + 2 NH3 + CO2.
2008-04-01 Updated RELATION is a GO:0016813 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines)
2007-11-08 Added SYNONYM (S)-ureidoglycolate amidohydrolase (decarboxylating)
2003-10-30 Updated DEFINITION Catalysis of the reaction: (-)-ureidoglycolate + H2O = glyoxylate + 2 NH3 + CO2.
2003-10-27 Added XREF MetaCyc:UREIDOGLYCOLATE-HYDROLASE-RXN
2003-10-23 Updated DEFINITION Catalysis of the reaction: (-)-ureidoglycolate + H2O = glyoxylate + 2 ammonia + CO2.
2003-03-19 Updated TERM ureidoglycolate hydrolase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: (-)-ureidoglycolate + H2O = glyoxylate + 2 ammonia + carbon dioxide.
2002-02-06 Updated TERM ureidoglycolate hydrolase
2001-04-03 Updated TERM ureidoglycolate hydrolase
2001-03-30 Added XREF EC:3.5.3.19
2001-03-30 Added TERM ureidoglycolate hydrolase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM ureidoglycolate hydrolase activity
2002-02-06 Updated TERM ureidoglycolate hydrolase
2001-04-03 Updated TERM ureidoglycolate hydrolase
2001-03-30 Added TERM ureidoglycolate hydrolase

Definition/synonyms

Timestamp Action Category Detail
2010-10-11 Added DEFINITION Catalysis of the reaction: (S)-ureidoglycolate + H(2)O + 2 H(+) = CO(2) + glyoxylate + 2 NH(4)(+).
2010-10-11 Deleted DEFINITION Catalysis of the reaction: (-)-ureidoglycolate + H2O = glyoxylate + 2 NH3 + CO2.
2008-05-13 Added DEFINITION Catalysis of the reaction: (-)-ureidoglycolate + H2O = glyoxylate + 2 NH3 + CO2.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: (-)-ureidoglycolate + H2O = glyoxylate + 2 NH3 + CO2.
2007-11-08 Added SYNONYM (S)-ureidoglycolate amidohydrolase (decarboxylating)
2003-10-30 Updated DEFINITION Catalysis of the reaction: (-)-ureidoglycolate + H2O = glyoxylate + 2 NH3 + CO2.
2003-10-23 Updated DEFINITION Catalysis of the reaction: (-)-ureidoglycolate + H2O = glyoxylate + 2 ammonia + CO2.
2002-11-27 Added DEFINITION Catalysis of the reaction: (-)-ureidoglycolate + H2O = glyoxylate + 2 ammonia + carbon dioxide.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016813 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines)

Cross-references

Timestamp Action Category Detail
2010-10-11 Added XREF RHEA:19812
2010-10-11 Added XREF KEGG:R00469
2003-10-27 Added XREF MetaCyc:UREIDOGLYCOLATE-HYDROLASE-RXN
2001-03-30 Added XREF EC:3.5.3.19
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