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GO:0004843 ubiquitin-specific protease activity

Term Information

ID GO:0004843
Name ubiquitin-specific protease activity
Ontology Molecular Function
Definition Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin.
Comment Note that this term is distinguished from 'ubiquitin thiolesterase activity ; GO:0004221' in that it encompasses hydrolysis of a peptide bond formed between ubiquitin and another protein.
GONUTS GO:0004843 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact deubiquitinase
exact ubiquitin C-terminal hydrolase activity
exact deubiquitinase activity
exact deubiquitinating enzyme
exact ubiquitin hydrolase activity
narrow UCH2
narrow UBP
exact deubiquitylase

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
InterPro IPR001578
InterPro IPR006615
InterPro IPR028767
InterPro IPR030298

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004843:
Relationship To GO:0004843 Child Term Child Term Name
Regulates GO:2000152 regulation of ubiquitin-specific protease activity
Negatively regulates GO:2000157 negative regulation of ubiquitin-specific protease activity
Positively regulates GO:2000158 positive regulation of ubiquitin-specific protease activity
Is a GO:0061578 Lys63-specific deubiquitinase activity
Is a GO:1990380 Lys48-specific deubiquitinase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
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Date
Assigned By
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Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004843. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004843 based on the entire annotation set Co-occurrence statistics for GO:0004843 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-05-16 Added SYNONYM deubiquitinase activity
2014-01-08 Added RELATION has part GO:0016579 (protein deubiquitination)
2013-12-21 Added DEFINITION Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin.
2013-12-21 Deleted DEFINITION Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal Gly of ubiquitin.
2013-12-21 Added RELATION is a GO:0036459 (ubiquitinyl hydrolase activity)
2013-12-21 Deleted XREF EC:3.4.19.12
2013-12-19 Deleted XREF KEGG:<new xref>
2013-12-18 Deleted DEFINITION Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences.
2013-12-18 Added DEFINITION Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal Gly of ubiquitin.
2013-12-18 Added XREF KEGG:<new xref>
2013-12-18 Added XREF EC:3.4.19.12
2013-12-18 Added SYNONYM ubiquitin C-terminal hydrolase activity
2013-11-22 Deleted DEFINITION Catalysis of the hydrolysis of various forms of polymeric ubiquitin.
2013-11-22 Added DEFINITION Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences.
2013-11-22 Updated TERM ubiquitin-specific protease activity
2013-11-22 Added SYNONYM deubiquitinase
2013-11-17 Deleted SYNONYM deubiquitinase
2013-11-17 Deleted DEFINITION Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences.
2013-11-17 Added DEFINITION Catalysis of the hydrolysis of various forms of polymeric ubiquitin.
2013-11-17 Updated TERM deubiquitinase activity
2010-12-05 Added SYNONYM deubiquitinating enzyme
2010-12-05 Added SYNONYM deubiquitylase
2010-12-05 Added SYNONYM deubiquitinase
2010-03-13 Deleted DEFINITION Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences. Will remove ubiquitin from larger leaving groups.
2010-03-13 Added DEFINITION Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences.
2009-10-28 Added SYNONYM ubiquitin hydrolase activity
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences. Will remove ubiquitin from larger leaving groups.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences. Will remove ubiquitin from larger leaving groups.
2008-04-01 Updated RELATION is a GO:0019783 (small conjugating protein-specific protease activity)
2007-08-09 Added SYNONYM UBP
2007-08-09 Added SYNONYM UCH2
2007-08-09 Deleted SYNONYM UBP
2007-08-09 Deleted SYNONYM UCH2
2004-04-19 Added SYNONYM UBP
2004-04-19 Added SYNONYM UCH2
2004-04-16 Deleted SYNONYM UBP
2004-04-16 Deleted SYNONYM UCH2
2003-03-19 Updated TERM ubiquitin-specific protease activity
2002-11-27 Updated DEFINITION Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences. Will remove ubiquitin from larger leaving groups.
2002-02-06 Updated TERM ubiquitin-specific protease
2001-08-06 Added DEFINITION Enzymes belonging to the C19 family of cysteine peptidases. Involved in the processing of various forms of polymeric ubiquitin and/or ubiquitin-like sequences. Will remove ubiquitin from larger leaving groups.
2001-04-03 Updated TERM ubiquitin-specific protease
2001-03-30 Added SYNONYM UBP
2001-03-30 Added SYNONYM UCH2
2001-03-30 Added TERM ubiquitin-specific protease

Term

Timestamp Action Category Detail
2013-11-22 Updated TERM ubiquitin-specific protease activity
2013-11-17 Updated TERM deubiquitinase activity
2003-03-19 Updated TERM ubiquitin-specific protease activity
2002-02-06 Updated TERM ubiquitin-specific protease
2001-04-03 Updated TERM ubiquitin-specific protease
2001-03-30 Added TERM ubiquitin-specific protease

Definition/synonyms

Timestamp Action Category Detail
2014-05-16 Added SYNONYM deubiquitinase activity
2013-12-21 Added DEFINITION Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin.
2013-12-21 Deleted DEFINITION Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal Gly of ubiquitin.
2013-12-18 Deleted DEFINITION Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences.
2013-12-18 Added DEFINITION Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal Gly of ubiquitin.
2013-12-18 Added SYNONYM ubiquitin C-terminal hydrolase activity
2013-11-22 Deleted DEFINITION Catalysis of the hydrolysis of various forms of polymeric ubiquitin.
2013-11-22 Added DEFINITION Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences.
2013-11-22 Added SYNONYM deubiquitinase
2013-11-17 Deleted SYNONYM deubiquitinase
2013-11-17 Deleted DEFINITION Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences.
2013-11-17 Added DEFINITION Catalysis of the hydrolysis of various forms of polymeric ubiquitin.
2010-12-05 Added SYNONYM deubiquitinating enzyme
2010-12-05 Added SYNONYM deubiquitylase
2010-12-05 Added SYNONYM deubiquitinase
2010-03-13 Deleted DEFINITION Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences. Will remove ubiquitin from larger leaving groups.
2010-03-13 Added DEFINITION Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences.
2009-10-28 Added SYNONYM ubiquitin hydrolase activity
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences. Will remove ubiquitin from larger leaving groups.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences. Will remove ubiquitin from larger leaving groups.
2007-08-09 Added SYNONYM UBP
2007-08-09 Added SYNONYM UCH2
2007-08-09 Deleted SYNONYM UBP
2007-08-09 Deleted SYNONYM UCH2
2004-04-19 Added SYNONYM UBP
2004-04-19 Added SYNONYM UCH2
2004-04-16 Deleted SYNONYM UBP
2004-04-16 Deleted SYNONYM UCH2
2002-11-27 Updated DEFINITION Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences. Will remove ubiquitin from larger leaving groups.
2001-08-06 Added DEFINITION Enzymes belonging to the C19 family of cysteine peptidases. Involved in the processing of various forms of polymeric ubiquitin and/or ubiquitin-like sequences. Will remove ubiquitin from larger leaving groups.
2001-03-30 Added SYNONYM UBP
2001-03-30 Added SYNONYM UCH2

Relationships

Timestamp Action Category Detail
2014-01-08 Added RELATION has part GO:0016579 (protein deubiquitination)
2013-12-21 Added RELATION is a GO:0036459 (ubiquitinyl hydrolase activity)
2008-04-01 Updated RELATION is a GO:0019783 (small conjugating protein-specific protease activity)

Cross-references

Timestamp Action Category Detail
2013-12-21 Deleted XREF EC:3.4.19.12
2013-12-19 Deleted XREF KEGG:<new xref>
2013-12-18 Added XREF KEGG:<new xref>
2013-12-18 Added XREF EC:3.4.19.12
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