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GO:0004842 ubiquitin-protein ligase activity

Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Term Information

ID GO:0004842
Name ubiquitin-protein ligase activity
Ontology Molecular Function
Definition Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Comment

Synonyms

Type Synonym
exact ubiquitin:protein-lysine N-ligase (AMP-forming) activity
related ubiquitin activity
exact ubiquitin-ligase activity
narrow anaphase-promoting complex activity
exact ubiquitin-conjugating enzyme activity
narrow E2
exact ubiquitin protein ligase activity
exact ubiquitin ligase activity
exact ubiquitin conjugating enzyme activity
narrow E3
exact ubiquitin protein-ligase activity

Cross-references associated with this term:

Database ID
MetaCyc UBIQUITIN--PROTEIN-LIGASE-RXN
EC 6.3.2.19
INTERPRO IPR015582
INTERPRO IPR003126
INTERPRO IPR010606
INTERPRO IPR015581
INTERPRO IPR013323
INTERPRO IPR003613

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Ancestor Chart

Visual display of a section of the GO directed acyclic graph (DAG) for a single GO term. Terms in the GO are linked to parent (more general) terms and often to child (more specific) terms by one or more 'relationships'

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Chart

Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016874 ligase activity
GO:0016879 ligase activity, forming carbon-nitrogen bonds
GO:0016881 acid-amino acid ligase activity
GO:0019787 small conjugating protein ligase activity
GO:0004842 ubiquitin-protein ligase activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
I GO:0034450 ubiquitin-ubiquitin ligase activity
I GO:0050372 ubiquitin-calmodulin ligase activity

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

This display shows those GO terms which have been annotated to the same proteins as this term.
Terms may have been co-annotated either by electronic (IEA) or manual annotation methods. Users can decide which evidence code type should be used in the calculation of the co-occurence statistics.
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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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