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GO:0004842 ubiquitin-protein transferase activity

Term Information

ID GO:0004842
Name ubiquitin-protein transferase activity
Ontology Molecular Function
Definition Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
PMID:9635407
Secondary IDs GO:0004840 GO:0004841
GONUTS GO:0004842 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow E2
narrow E3
narrow anaphase-promoting complex activity
related ubiquitin ligase activity
related ubiquitin protein-ligase activity
exact ubiquitin-ligase activity
related ubiquitin conjugating enzyme activity
related ubiquitin-conjugating enzyme activity
related ubiquitin protein ligase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
InterPro IPR000569
InterPro IPR003613
InterPro IPR003977
InterPro IPR010489
InterPro IPR010606
InterPro IPR011364
InterPro IPR013323
InterPro IPR022103
InterPro IPR022170
InterPro IPR024162
InterPro IPR024928
InterPro IPR024991
InterPro IPR025725
InterPro IPR026254
InterPro IPR026261
InterPro IPR026848
InterPro IPR027047
InterPro IPR027133
InterPro IPR027139
InterPro IPR027726
InterPro IPR028795
InterPro IPR029487
KEGG R03876
MetaCyc UBIQUITIN--PROTEIN-LIGASE-RXN

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004842:
Relationship To GO:0004842 Child Term Child Term Name
Regulates GO:0051438 regulation of ubiquitin-protein transferase activity
Positively regulates GO:0051443 positive regulation of ubiquitin-protein transferase activity
Negatively regulates GO:0051444 negative regulation of ubiquitin-protein transferase activity
Negatively regulates GO:0055105 ubiquitin-protein transferase inhibitor activity
Regulates GO:0055106 ubiquitin-protein transferase regulator activity
Is a GO:0050372 ubiquitin-calmodulin ligase activity
Is a GO:0090302 mitotic anaphase-promoting complex activity
Is a GO:0061630 ubiquitin protein ligase activity
Is a GO:0061631 ubiquitin conjugating enzyme activity
Positively regulates GO:0097027 ubiquitin-protein transferase activator activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004842. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004842 based on the entire annotation set Co-occurrence statistics for GO:0004842 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-05-20 Added SYNONYM ubiquitin ligase activity
2014-05-20 Deleted SYNONYM ubiquitin protein ligase activity
2014-05-20 Deleted XREF EC:6.3.2.19
2014-05-20 Added RELATION is a GO:0016740 (transferase activity)
2014-05-20 Deleted RELATION is a GO:0019787 (small conjugating protein ligase activity)
2014-05-20 Updated TERM ubiquitin-protein transferase activity
2014-05-20 Deleted SYNONYM ubiquitin ligase activity
2014-05-20 Deleted SYNONYM ubiquitin conjugating enzyme activity
2014-05-20 Deleted SYNONYM ubiquitin protein-ligase activity
2014-05-20 Deleted SYNONYM ubiquitin:protein-lysine N-ligase (AMP-forming) activity
2014-05-20 Deleted DEFINITION Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
2014-05-20 Added DEFINITION Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
2014-05-20 Deleted SYNONYM ubiquitin-conjugating enzyme activity
2014-05-20 Added SYNONYM ubiquitin conjugating enzyme activity
2014-05-20 Added SYNONYM ubiquitin-conjugating enzyme activity
2014-05-20 Added SYNONYM ubiquitin protein-ligase activity
2014-05-20 Added SYNONYM ubiquitin protein ligase activity
2013-05-31 Deleted SYNONYM ubiquitin activity
2010-10-08 Added XREF KEGG:R03876
2010-06-15 Added RELATION part of GO:0016567 (protein ubiquitination)
2010-06-14 Deleted RELATION part of GO:0016567 (protein ubiquitination)
2010-06-08 Added RELATION part of GO:0016567 (protein ubiquitination)
2009-05-03 Added SYNONYM anaphase-promoting complex activity
2009-02-25 Deleted SYNONYM ubiquitin-activating enzyme
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
2008-04-01 Updated RELATION is a GO:0019787 (small conjugating protein ligase activity)
2008-04-01 Deleted RELATION is a GO:0008639 (small protein conjugating enzyme activity)
2008-04-01 Updated RELATION is a GO:0008639 (small protein conjugating enzyme activity)
2007-12-14 Added SYNONYM ubiquitin:protein-lysine N-ligase (AMP-forming) activity
2007-09-06 Added SYNONYM ubiquitin activity
2007-08-09 Added SYNONYM E2
2007-08-09 Added SYNONYM E3
2007-08-09 Added SYNONYM ubiquitin conjugating enzyme activity
2007-08-09 Added SYNONYM ubiquitin ligase activity
2007-08-09 Added SYNONYM ubiquitin protein ligase activity
2007-08-09 Added SYNONYM ubiquitin protein-ligase activity
2007-08-09 Added SYNONYM ubiquitin-activating enzyme
2007-08-09 Added SYNONYM ubiquitin-conjugating enzyme activity
2007-08-09 Added SYNONYM ubiquitin-ligase activity
2007-08-09 Deleted SYNONYM E2
2007-08-09 Deleted SYNONYM ubiquitin conjugating enzyme activity
2007-08-09 Deleted SYNONYM ubiquitin protein ligase activity
2007-08-09 Deleted SYNONYM ubiquitin protein-ligase activity
2007-08-09 Deleted SYNONYM ubiquitin-activating enzyme
2007-08-09 Deleted SYNONYM ubiquitin-conjugating enzyme activity
2007-08-09 Deleted SYNONYM ubiquitin-ligase activity
2007-08-09 Deleted SYNONYM E3
2007-08-09 Deleted SYNONYM ubiquitin ligase activity
2007-02-27 Updated DEFINITION Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
2007-02-23 Added SYNONYM E2
2007-02-23 Added SYNONYM ubiquitin conjugating enzyme activity
2007-02-23 Added SYNONYM ubiquitin protein ligase activity
2007-02-23 Added SYNONYM ubiquitin protein-ligase activity
2007-02-23 Added SYNONYM ubiquitin-activating enzyme
2007-02-23 Added SYNONYM ubiquitin-conjugating enzyme activity
2007-02-23 Added SECONDARY GO:0004841 (cyclin selective ubiquitin conjugating enzyme)
2007-02-23 Added SECONDARY GO:0004840 (ubiquitin conjugating enzyme activity)
2005-09-10 Added SYNONYM ubiquitin ligase activity
2005-09-10 Added SYNONYM ubiquitin-ligase activity
2004-04-19 Added SYNONYM E3
2004-04-16 Deleted SYNONYM E3
2003-10-27 Added SYNONYM E3
2003-10-27 Added XREF MetaCyc:UBIQUITIN--PROTEIN-LIGASE-RXN
2003-08-21 Deleted SYNONYM E3
2003-03-26 Updated DEFINITION Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. Catalyzes the mediation of substrate recognition in ubiquitin-mediated protein degradation; binds directly to the substrate and its cognate E2 (ubiquitin conjugating enzyme).
2003-03-19 Updated TERM ubiquitin-protein ligase activity
2002-11-27 Updated DEFINITION Catalysis of the mediation of substrate recognition in ubiquitin-mediated protein degradation; binds directly to the substrate and its cognate E2 (ubiquitin conjugating enzyme). Many E3s are single proteins but there is evidence that suggests multiprotein E3 complexes are prevalent.
2002-02-06 Updated TERM ubiquitin-protein ligase
2001-11-07 Updated TERM ubiquitin-protein ligase
2001-08-06 Added DEFINITION An enzyme that mediates substrate recognition in ubiquitin-mediate protein degradation; binds directly to the substrate and its cognate E2 (ubiquitin conjugating enzyme). Many E3s are single proteins but there is evidence that suggests multiprotein E3 complexes are prevalent.
2001-04-03 Updated TERM ubiquitin--protein ligase
2001-03-30 Added XREF EC:6.3.2.19
2001-03-30 Added SYNONYM E3
2001-03-30 Added TERM ubiquitin--protein ligase

Term

Timestamp Action Category Detail
2014-05-20 Updated TERM ubiquitin-protein transferase activity
2003-03-19 Updated TERM ubiquitin-protein ligase activity
2002-02-06 Updated TERM ubiquitin-protein ligase
2001-11-07 Updated TERM ubiquitin-protein ligase
2001-04-03 Updated TERM ubiquitin--protein ligase
2001-03-30 Added TERM ubiquitin--protein ligase

Definition/synonyms

Timestamp Action Category Detail
2014-05-20 Added SYNONYM ubiquitin ligase activity
2014-05-20 Deleted SYNONYM ubiquitin protein ligase activity
2014-05-20 Deleted SYNONYM ubiquitin ligase activity
2014-05-20 Deleted SYNONYM ubiquitin conjugating enzyme activity
2014-05-20 Deleted SYNONYM ubiquitin protein-ligase activity
2014-05-20 Deleted SYNONYM ubiquitin:protein-lysine N-ligase (AMP-forming) activity
2014-05-20 Deleted DEFINITION Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
2014-05-20 Added DEFINITION Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
2014-05-20 Deleted SYNONYM ubiquitin-conjugating enzyme activity
2014-05-20 Added SYNONYM ubiquitin conjugating enzyme activity
2014-05-20 Added SYNONYM ubiquitin-conjugating enzyme activity
2014-05-20 Added SYNONYM ubiquitin protein-ligase activity
2014-05-20 Added SYNONYM ubiquitin protein ligase activity
2013-05-31 Deleted SYNONYM ubiquitin activity
2009-05-03 Added SYNONYM anaphase-promoting complex activity
2009-02-25 Deleted SYNONYM ubiquitin-activating enzyme
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
2007-12-14 Added SYNONYM ubiquitin:protein-lysine N-ligase (AMP-forming) activity
2007-09-06 Added SYNONYM ubiquitin activity
2007-08-09 Added SYNONYM E2
2007-08-09 Added SYNONYM E3
2007-08-09 Added SYNONYM ubiquitin conjugating enzyme activity
2007-08-09 Added SYNONYM ubiquitin ligase activity
2007-08-09 Added SYNONYM ubiquitin protein ligase activity
2007-08-09 Added SYNONYM ubiquitin protein-ligase activity
2007-08-09 Added SYNONYM ubiquitin-activating enzyme
2007-08-09 Added SYNONYM ubiquitin-conjugating enzyme activity
2007-08-09 Added SYNONYM ubiquitin-ligase activity
2007-08-09 Deleted SYNONYM E2
2007-08-09 Deleted SYNONYM ubiquitin conjugating enzyme activity
2007-08-09 Deleted SYNONYM ubiquitin protein ligase activity
2007-08-09 Deleted SYNONYM ubiquitin protein-ligase activity
2007-08-09 Deleted SYNONYM ubiquitin-activating enzyme
2007-08-09 Deleted SYNONYM ubiquitin-conjugating enzyme activity
2007-08-09 Deleted SYNONYM ubiquitin-ligase activity
2007-08-09 Deleted SYNONYM E3
2007-08-09 Deleted SYNONYM ubiquitin ligase activity
2007-02-27 Updated DEFINITION Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
2007-02-23 Added SYNONYM E2
2007-02-23 Added SYNONYM ubiquitin conjugating enzyme activity
2007-02-23 Added SYNONYM ubiquitin protein ligase activity
2007-02-23 Added SYNONYM ubiquitin protein-ligase activity
2007-02-23 Added SYNONYM ubiquitin-activating enzyme
2007-02-23 Added SYNONYM ubiquitin-conjugating enzyme activity
2005-09-10 Added SYNONYM ubiquitin ligase activity
2005-09-10 Added SYNONYM ubiquitin-ligase activity
2004-04-19 Added SYNONYM E3
2004-04-16 Deleted SYNONYM E3
2003-10-27 Added SYNONYM E3
2003-08-21 Deleted SYNONYM E3
2003-03-26 Updated DEFINITION Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. Catalyzes the mediation of substrate recognition in ubiquitin-mediated protein degradation; binds directly to the substrate and its cognate E2 (ubiquitin conjugating enzyme).
2002-11-27 Updated DEFINITION Catalysis of the mediation of substrate recognition in ubiquitin-mediated protein degradation; binds directly to the substrate and its cognate E2 (ubiquitin conjugating enzyme). Many E3s are single proteins but there is evidence that suggests multiprotein E3 complexes are prevalent.
2001-08-06 Added DEFINITION An enzyme that mediates substrate recognition in ubiquitin-mediate protein degradation; binds directly to the substrate and its cognate E2 (ubiquitin conjugating enzyme). Many E3s are single proteins but there is evidence that suggests multiprotein E3 complexes are prevalent.
2001-03-30 Added SYNONYM E3

Relationships

Timestamp Action Category Detail
2014-05-20 Added RELATION is a GO:0016740 (transferase activity)
2014-05-20 Deleted RELATION is a GO:0019787 (small conjugating protein ligase activity)
2010-06-15 Added RELATION part of GO:0016567 (protein ubiquitination)
2010-06-14 Deleted RELATION part of GO:0016567 (protein ubiquitination)
2010-06-08 Added RELATION part of GO:0016567 (protein ubiquitination)
2008-04-01 Updated RELATION is a GO:0019787 (small conjugating protein ligase activity)
2008-04-01 Deleted RELATION is a GO:0008639 (small protein conjugating enzyme activity)
2008-04-01 Updated RELATION is a GO:0008639 (small protein conjugating enzyme activity)

Cross-references

Timestamp Action Category Detail
2014-05-20 Deleted XREF EC:6.3.2.19
2010-10-08 Added XREF KEGG:R03876
2003-10-27 Added XREF MetaCyc:UBIQUITIN--PROTEIN-LIGASE-RXN
2001-03-30 Added XREF EC:6.3.2.19

Other

Timestamp Action Category Detail
2007-02-23 Added SECONDARY GO:0004841 (cyclin selective ubiquitin conjugating enzyme)
2007-02-23 Added SECONDARY GO:0004840 (ubiquitin conjugating enzyme activity)
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