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GO:0004839 ubiquitin activating enzyme activity

Term Information

ID GO:0004839
Name ubiquitin activating enzyme activity
Ontology Molecular Function
Definition Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate.
PMID:10072378
GONUTS GO:0004839 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact E1

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
Wikipedia Ubiquitin-activating_enzyme

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004839:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004839. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004839 based on the entire annotation set Co-occurrence statistics for GO:0004839 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-05-20 Added RELATION is a GO:0016877 (ligase activity, forming carbon-sulfur bonds)
2014-05-20 Added RELATION part of GO:0016567 (protein ubiquitination)
2014-05-20 Deleted DEFINITION Catalysis of the reaction: a protein L-lysine + a ubiquitin + ATP = a protein-N-ubiquityl-lysine + AMP + diphosphate. This reaction is the activation of the C-terminal carboxyl group of ubiquitin by the formation of a high-energy thiolester bond in an ATP-dependent manner.
2014-05-20 Added DEFINITION Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate.
2010-10-08 Deleted XREF MetaCyc:UBIQUITIN--PROTEIN-LIGASE-RXN
2010-10-08 Deleted XREF EC:6.3.2.19
2010-09-24 Added DEFINITION Catalysis of the reaction: a protein L-lysine + a ubiquitin + ATP = a protein-N-ubiquityl-lysine + AMP + diphosphate. This reaction is the activation of the C-terminal carboxyl group of ubiquitin by the formation of a high-energy thiolester bond in an ATP-dependent manner.
2010-09-24 Deleted DEFINITION Catalysis of the activation of the C-terminal carboxyl group of ubiquitin by the formation of a high-energy thiolester bond in an ATP-dependent manner.
2010-09-24 Added XREF EC:6.3.2.19
2009-05-21 Added XREF MetaCyc:UBIQUITIN--PROTEIN-LIGASE-RXN
2009-02-25 Added XREF Wikipedia:Ubiquitin-activating_enzyme
2008-05-13 Added DEFINITION Catalysis of the activation of the C-terminal carboxyl group of ubiquitin by the formation of a high-energy thiolester bond in an ATP-dependent manner.
2008-05-12 Deleted DEFINITION Catalysis of the activation of the C-terminal carboxyl group of ubiquitin by the formation of a high-energy thiolester bond in an ATP-dependent manner.
2008-04-01 Updated RELATION is a GO:0008641 (small protein activating enzyme activity)
2007-08-09 Added SYNONYM E1
2007-08-09 Deleted SYNONYM E1
2006-01-26 Updated DEFINITION Catalysis of the activation of the C-terminal carboxyl group of ubiquitin by the formation of a high-energy thiolester bond in an ATP-dependent manner.
2004-04-19 Added SYNONYM E1
2004-04-16 Deleted SYNONYM E1
2003-08-19 Updated DEFINITION Catalysis of the activation of the C-terminal carboxyl group of ubiquitin by the formation of a high-energy thioester bond in an ATP-dependent manner.
2003-03-19 Updated TERM ubiquitin activating enzyme activity
2002-02-06 Updated TERM ubiquitin activating enzyme
2001-08-06 Added DEFINITION An enzyme that attaches itself to ubiquitin in an ATP-dependent reaction to form a high-energy thiolester bond.
2001-04-03 Updated TERM ubiquitin activating enzyme
2001-03-30 Added SYNONYM E1
2001-03-30 Added TERM ubiquitin activating enzyme

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM ubiquitin activating enzyme activity
2002-02-06 Updated TERM ubiquitin activating enzyme
2001-04-03 Updated TERM ubiquitin activating enzyme
2001-03-30 Added TERM ubiquitin activating enzyme

Definition/synonyms

Timestamp Action Category Detail
2014-05-20 Deleted DEFINITION Catalysis of the reaction: a protein L-lysine + a ubiquitin + ATP = a protein-N-ubiquityl-lysine + AMP + diphosphate. This reaction is the activation of the C-terminal carboxyl group of ubiquitin by the formation of a high-energy thiolester bond in an ATP-dependent manner.
2014-05-20 Added DEFINITION Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate.
2010-09-24 Added DEFINITION Catalysis of the reaction: a protein L-lysine + a ubiquitin + ATP = a protein-N-ubiquityl-lysine + AMP + diphosphate. This reaction is the activation of the C-terminal carboxyl group of ubiquitin by the formation of a high-energy thiolester bond in an ATP-dependent manner.
2010-09-24 Deleted DEFINITION Catalysis of the activation of the C-terminal carboxyl group of ubiquitin by the formation of a high-energy thiolester bond in an ATP-dependent manner.
2008-05-13 Added DEFINITION Catalysis of the activation of the C-terminal carboxyl group of ubiquitin by the formation of a high-energy thiolester bond in an ATP-dependent manner.
2008-05-12 Deleted DEFINITION Catalysis of the activation of the C-terminal carboxyl group of ubiquitin by the formation of a high-energy thiolester bond in an ATP-dependent manner.
2007-08-09 Added SYNONYM E1
2007-08-09 Deleted SYNONYM E1
2006-01-26 Updated DEFINITION Catalysis of the activation of the C-terminal carboxyl group of ubiquitin by the formation of a high-energy thiolester bond in an ATP-dependent manner.
2004-04-19 Added SYNONYM E1
2004-04-16 Deleted SYNONYM E1
2003-08-19 Updated DEFINITION Catalysis of the activation of the C-terminal carboxyl group of ubiquitin by the formation of a high-energy thioester bond in an ATP-dependent manner.
2001-08-06 Added DEFINITION An enzyme that attaches itself to ubiquitin in an ATP-dependent reaction to form a high-energy thiolester bond.
2001-03-30 Added SYNONYM E1

Relationships

Timestamp Action Category Detail
2014-05-20 Added RELATION is a GO:0016877 (ligase activity, forming carbon-sulfur bonds)
2014-05-20 Added RELATION part of GO:0016567 (protein ubiquitination)
2008-04-01 Updated RELATION is a GO:0008641 (small protein activating enzyme activity)

Cross-references

Timestamp Action Category Detail
2010-10-08 Deleted XREF MetaCyc:UBIQUITIN--PROTEIN-LIGASE-RXN
2010-10-08 Deleted XREF EC:6.3.2.19
2010-09-24 Added XREF EC:6.3.2.19
2009-05-21 Added XREF MetaCyc:UBIQUITIN--PROTEIN-LIGASE-RXN
2009-02-25 Added XREF Wikipedia:Ubiquitin-activating_enzyme
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