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GO:0004812 aminoacyl-tRNA ligase activity

Term Information

ID GO:0004812
Name aminoacyl-tRNA ligase activity
Ontology Molecular Function
Definition Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP.
Comment Note that the bond resulting from this reaction is a carboxylic acid ester bond, linking the alpha carboxyl group of the amino acid to either the 2' or 3' hydroxyl of the 3'- terminal adenyl residue of the tRNA.
Secondary IDs GO:0017100
GONUTS GO:0004812 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related aminoacyl-tRNA synthetase auxiliary protein activity
exact aminoacyl-tRNA synthetase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_metagenomics119

Cross-references

Database ID
EC 6.1.1.-
InterPro IPR000738
InterPro IPR001412
InterPro IPR002300
InterPro IPR002305
InterPro IPR002312
InterPro IPR002314
InterPro IPR002319
InterPro IPR004115
InterPro IPR004364
InterPro IPR005246
InterPro IPR006195
InterPro IPR007639
InterPro IPR009080
InterPro IPR015413
InterPro IPR018150
InterPro IPR020059
InterPro IPR020061
UniProtKB-KW Aminoacyl-tRNA synthetase

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004812:
Relationship To GO:0004812 Child Term Child Term Name
Is a GO:0050560 aspartate-tRNA(Asn) ligase activity
Is a GO:0050561 glutamate-tRNA(Gln) ligase activity
Is a GO:0050562 lysine-tRNA(Pyl) ligase activity
Is a GO:0004813 alanine-tRNA ligase activity
Is a GO:0004814 arginine-tRNA ligase activity
Is a GO:0004815 aspartate-tRNA ligase activity
Is a GO:0004816 asparagine-tRNA ligase activity
Is a GO:0004817 cysteine-tRNA ligase activity
Is a GO:0004818 glutamate-tRNA ligase activity
Is a GO:0004819 glutamine-tRNA ligase activity
Is a GO:0004820 glycine-tRNA ligase activity
Is a GO:0004821 histidine-tRNA ligase activity
Is a GO:0004822 isoleucine-tRNA ligase activity
Is a GO:0004823 leucine-tRNA ligase activity
Is a GO:0004824 lysine-tRNA ligase activity
Is a GO:0004825 methionine-tRNA ligase activity
Is a GO:0004826 phenylalanine-tRNA ligase activity
Is a GO:0004827 proline-tRNA ligase activity
Is a GO:0004828 serine-tRNA ligase activity
Is a GO:0004829 threonine-tRNA ligase activity
Is a GO:0004830 tryptophan-tRNA ligase activity
Is a GO:0004831 tyrosine-tRNA ligase activity
Is a GO:0004832 valine-tRNA ligase activity
Is a GO:0043816 phosphoserine-tRNA(Cys) ligase activity
Is a GO:0043767 pyrrolysyl-tRNA synthetase activity
Is a GO:0098618 selenomethionine-tRNA ligase activity
Is a GO:0098619 selenocysteine-tRNA ligase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004812. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004812 based on the entire annotation set Co-occurrence statistics for GO:0004812 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_metagenomics
2012-02-17 Added SLIM goslim_metagenomics
2010-10-31 Added SECONDARY GO:0017100 (aminoacyl-tRNA synthetase auxiliary protein activity)
2010-10-31 Added SYNONYM aminoacyl-tRNA synthetase auxiliary protein activity
2010-10-08 Deleted DEFINITION Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP.
2010-10-08 Added DEFINITION Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP.
2008-05-13 Added DEFINITION Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP.
2008-05-12 Deleted DEFINITION Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP.
2008-04-01 Updated RELATION is a GO:0016876 (ligase activity, forming aminoacyl-tRNA and related compounds)
2007-08-09 Added SYNONYM aminoacyl-tRNA synthetase activity
2007-08-09 Deleted SYNONYM aminoacyl-tRNA synthetase activity
2006-02-19 Added SYNONYM aminoacyl-tRNA synthetase activity
2006-02-19 Updated TERM aminoacyl-tRNA ligase activity
2003-03-19 Updated TERM tRNA ligase activity
2002-11-27 Updated DEFINITION Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP.
2002-02-06 Updated TERM tRNA ligase
2001-08-06 Added DEFINITION any enzyme of the subclasss EC 6.6.1 catalyzing the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP.
2001-04-03 Updated TERM tRNA ligase
2001-03-30 Added XREF EC:6.1.1.-
2001-03-30 Added TERM tRNA ligase

Term

Timestamp Action Category Detail
2006-02-19 Updated TERM aminoacyl-tRNA ligase activity
2003-03-19 Updated TERM tRNA ligase activity
2002-02-06 Updated TERM tRNA ligase
2001-04-03 Updated TERM tRNA ligase
2001-03-30 Added TERM tRNA ligase

Definition/synonyms

Timestamp Action Category Detail
2010-10-31 Added SYNONYM aminoacyl-tRNA synthetase auxiliary protein activity
2010-10-08 Deleted DEFINITION Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP.
2010-10-08 Added DEFINITION Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP.
2008-05-13 Added DEFINITION Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP.
2008-05-12 Deleted DEFINITION Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP.
2007-08-09 Added SYNONYM aminoacyl-tRNA synthetase activity
2007-08-09 Deleted SYNONYM aminoacyl-tRNA synthetase activity
2006-02-19 Added SYNONYM aminoacyl-tRNA synthetase activity
2002-11-27 Updated DEFINITION Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP.
2001-08-06 Added DEFINITION any enzyme of the subclasss EC 6.6.1 catalyzing the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016876 (ligase activity, forming aminoacyl-tRNA and related compounds)

Cross-references

Timestamp Action Category Detail
2001-03-30 Added XREF EC:6.1.1.-

Other

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_metagenomics
2012-02-17 Added SLIM goslim_metagenomics
2010-10-31 Added SECONDARY GO:0017100 (aminoacyl-tRNA synthetase auxiliary protein activity)
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