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GO:0004767 sphingomyelin phosphodiesterase activity

Term Information

ID GO:0004767
Name sphingomyelin phosphodiesterase activity
Ontology Molecular Function
Definition Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+).
Secondary IDs GO:0030230 GO:0030231
GONUTS GO:0004767 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow neutral sphingomyelinase activity
narrow acid sphingomyelinase activity
narrow neutral sphingomyelin phosphodiesterase
narrow acid sphingomyelin phosphodiesterase
exact sphingomyelinase activity
exact sphingomyelin cholinephosphohydrolase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.1.4.12
InterPro IPR011160
InterPro IPR017064
InterPro IPR029895
KEGG R02541
MetaCyc SPHINGOMYELIN-PHOSPHODIESTERASE-RXN
RHEA 19256

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004767:
Relationship To GO:0004767 Child Term Child Term Name
Positively regulates GO:0016230 sphingomyelin phosphodiesterase activator activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004767. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004767 based on the entire annotation set Co-occurrence statistics for GO:0004767 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-10-11 Deleted DEFINITION Catalysis of the reaction: sphingomyelin + H2O = N-acylsphingosine + choline phosphate.
2010-10-11 Added DEFINITION Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+).
2010-10-11 Added XREF RHEA:19256
2010-10-11 Added XREF KEGG:R02541
2008-05-13 Added DEFINITION Catalysis of the reaction: sphingomyelin + H2O = N-acylsphingosine + choline phosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: sphingomyelin + H2O = N-acylsphingosine + choline phosphate.
2008-04-01 Updated RELATION is a GO:0004620 (phospholipase activity)
2008-04-01 Updated RELATION is a GO:0008081 (phosphoric diester hydrolase activity)
2007-11-08 Added SYNONYM sphingomyelin cholinephosphohydrolase activity
2007-11-08 Added SYNONYM sphingomyelinase activity
2007-11-08 Deleted SYNONYM sphingomyelinase
2007-09-06 Added SYNONYM acid sphingomyelinase activity
2007-09-06 Added SYNONYM neutral sphingomyelinase activity
2007-09-06 Deleted SYNONYM acid sphingomyelinase
2007-09-06 Deleted SYNONYM neutral sphingomyelinase
2007-08-09 Added SYNONYM acid sphingomyelin phosphodiesterase
2007-08-09 Added SYNONYM acid sphingomyelinase
2007-08-09 Added SYNONYM neutral sphingomyelin phosphodiesterase
2007-08-09 Added SYNONYM neutral sphingomyelinase
2007-08-09 Added SYNONYM sphingomyelinase
2007-08-09 Deleted SYNONYM acid sphingomyelin phosphodiesterase
2007-08-09 Deleted SYNONYM acid sphingomyelinase
2007-08-09 Deleted SYNONYM neutral sphingomyelin phosphodiesterase
2007-08-09 Deleted SYNONYM neutral sphingomyelinase
2007-08-09 Deleted SYNONYM sphingomyelinase
2004-04-19 Added SYNONYM acid sphingomyelin phosphodiesterase
2004-04-19 Added SYNONYM acid sphingomyelinase
2004-04-19 Added SYNONYM neutral sphingomyelin phosphodiesterase
2004-04-19 Added SYNONYM neutral sphingomyelinase
2004-04-19 Added SYNONYM sphingomyelinase
2004-04-16 Deleted SYNONYM acid sphingomyelin phosphodiesterase
2004-04-16 Deleted SYNONYM acid sphingomyelinase
2004-04-16 Deleted SYNONYM neutral sphingomyelin phosphodiesterase
2004-04-16 Deleted SYNONYM neutral sphingomyelinase
2004-04-16 Deleted SYNONYM sphingomyelinase
2003-10-27 Added SYNONYM sphingomyelinase
2003-10-27 Added SYNONYM acid sphingomyelin phosphodiesterase
2003-10-27 Added SYNONYM acid sphingomyelinase
2003-10-27 Added SYNONYM neutral sphingomyelin phosphodiesterase
2003-10-27 Added SYNONYM neutral sphingomyelinase
2003-10-27 Added XREF MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN
2003-08-21 Deleted SYNONYM acid sphingomyelin phosphodiesterase
2003-08-21 Deleted SYNONYM acid sphingomyelinase
2003-08-21 Deleted SYNONYM neutral sphingomyelin phosphodiesterase
2003-08-21 Deleted SYNONYM neutral sphingomyelinase
2003-08-21 Deleted SYNONYM sphingomyelinase
2003-03-19 Updated TERM sphingomyelin phosphodiesterase activity
2003-02-11 Added SYNONYM neutral sphingomyelinase
2003-02-11 Added SYNONYM neutral sphingomyelin phosphodiesterase
2003-02-11 Added SYNONYM acid sphingomyelinase
2003-02-11 Added SYNONYM acid sphingomyelin phosphodiesterase
2003-02-11 Added SECONDARY GO:0030230 (acid sphingomyelin phosphodiesterase)
2003-02-11 Added SECONDARY GO:0030231 (neutral sphingomyelin phosphodiesterase)
2002-11-27 Added DEFINITION Catalysis of the reaction: sphingomyelin + H2O = N-acylsphingosine + choline phosphate.
2002-02-06 Updated TERM sphingomyelin phosphodiesterase
2001-09-06 Added SYNONYM sphingomyelinase
2001-04-03 Updated TERM sphingomyelin phosphodiesterase
2001-03-30 Added XREF EC:3.1.4.12
2001-03-30 Added TERM sphingomyelin phosphodiesterase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM sphingomyelin phosphodiesterase activity
2002-02-06 Updated TERM sphingomyelin phosphodiesterase
2001-04-03 Updated TERM sphingomyelin phosphodiesterase
2001-03-30 Added TERM sphingomyelin phosphodiesterase

Definition/synonyms

Timestamp Action Category Detail
2010-10-11 Deleted DEFINITION Catalysis of the reaction: sphingomyelin + H2O = N-acylsphingosine + choline phosphate.
2010-10-11 Added DEFINITION Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+).
2008-05-13 Added DEFINITION Catalysis of the reaction: sphingomyelin + H2O = N-acylsphingosine + choline phosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: sphingomyelin + H2O = N-acylsphingosine + choline phosphate.
2007-11-08 Added SYNONYM sphingomyelin cholinephosphohydrolase activity
2007-11-08 Added SYNONYM sphingomyelinase activity
2007-11-08 Deleted SYNONYM sphingomyelinase
2007-09-06 Added SYNONYM acid sphingomyelinase activity
2007-09-06 Added SYNONYM neutral sphingomyelinase activity
2007-09-06 Deleted SYNONYM acid sphingomyelinase
2007-09-06 Deleted SYNONYM neutral sphingomyelinase
2007-08-09 Added SYNONYM acid sphingomyelin phosphodiesterase
2007-08-09 Added SYNONYM acid sphingomyelinase
2007-08-09 Added SYNONYM neutral sphingomyelin phosphodiesterase
2007-08-09 Added SYNONYM neutral sphingomyelinase
2007-08-09 Added SYNONYM sphingomyelinase
2007-08-09 Deleted SYNONYM acid sphingomyelin phosphodiesterase
2007-08-09 Deleted SYNONYM acid sphingomyelinase
2007-08-09 Deleted SYNONYM neutral sphingomyelin phosphodiesterase
2007-08-09 Deleted SYNONYM neutral sphingomyelinase
2007-08-09 Deleted SYNONYM sphingomyelinase
2004-04-19 Added SYNONYM acid sphingomyelin phosphodiesterase
2004-04-19 Added SYNONYM acid sphingomyelinase
2004-04-19 Added SYNONYM neutral sphingomyelin phosphodiesterase
2004-04-19 Added SYNONYM neutral sphingomyelinase
2004-04-19 Added SYNONYM sphingomyelinase
2004-04-16 Deleted SYNONYM acid sphingomyelin phosphodiesterase
2004-04-16 Deleted SYNONYM acid sphingomyelinase
2004-04-16 Deleted SYNONYM neutral sphingomyelin phosphodiesterase
2004-04-16 Deleted SYNONYM neutral sphingomyelinase
2004-04-16 Deleted SYNONYM sphingomyelinase
2003-10-27 Added SYNONYM sphingomyelinase
2003-10-27 Added SYNONYM acid sphingomyelin phosphodiesterase
2003-10-27 Added SYNONYM acid sphingomyelinase
2003-10-27 Added SYNONYM neutral sphingomyelin phosphodiesterase
2003-10-27 Added SYNONYM neutral sphingomyelinase
2003-08-21 Deleted SYNONYM acid sphingomyelin phosphodiesterase
2003-08-21 Deleted SYNONYM acid sphingomyelinase
2003-08-21 Deleted SYNONYM neutral sphingomyelin phosphodiesterase
2003-08-21 Deleted SYNONYM neutral sphingomyelinase
2003-08-21 Deleted SYNONYM sphingomyelinase
2003-02-11 Added SYNONYM neutral sphingomyelinase
2003-02-11 Added SYNONYM neutral sphingomyelin phosphodiesterase
2003-02-11 Added SYNONYM acid sphingomyelinase
2003-02-11 Added SYNONYM acid sphingomyelin phosphodiesterase
2002-11-27 Added DEFINITION Catalysis of the reaction: sphingomyelin + H2O = N-acylsphingosine + choline phosphate.
2001-09-06 Added SYNONYM sphingomyelinase

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0004620 (phospholipase activity)
2008-04-01 Updated RELATION is a GO:0008081 (phosphoric diester hydrolase activity)

Cross-references

Timestamp Action Category Detail
2010-10-11 Added XREF RHEA:19256
2010-10-11 Added XREF KEGG:R02541
2003-10-27 Added XREF MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN
2001-03-30 Added XREF EC:3.1.4.12

Other

Timestamp Action Category Detail
2003-02-11 Added SECONDARY GO:0030230 (acid sphingomyelin phosphodiesterase)
2003-02-11 Added SECONDARY GO:0030231 (neutral sphingomyelin phosphodiesterase)
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