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GO:0004748 ribonucleoside-diphosphate reductase activityCatalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.
Term Information
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| Type | Synonym |
| exact | 2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase activity |
| broad | ribonucleotide reductase activity |
| exact | 2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase activity |
| exact | nucleoside diphosphate reductase activity |
| exact | ribonucleoside 5'-diphosphate reductase activity |
| exact | ribonucleoside diphosphate reductase activity |
| exact | ribonucleotide diphosphate reductase activity |
| exact | RNR |
| related | purine/pyrimidine nucleoside diphosphate reduction |
| Database | ID |
| INTERPRO | IPR008926 |
| INTERPRO | IPR013554 |
| INTERPRO | IPR000788 |
| MetaCyc | RIBONUCLEOSIDE-DIP-REDUCTI-RXN |
| EC | 1.17.4.1 |
| INTERPRO | IPR013509 |
| INTERPRO | IPR013344 |
| INTERPRO | IPR000358 |
| INTERPRO | IPR013678 |
GO:0006162 purine/pyrimidine nucleoside diphosphate reduction |
(consider GO:0004748) |
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0003674 molecular_function | |||||
![]() | GO:0003824 catalytic activity | ||||
![]() | ![]() | GO:0016491 oxidoreductase activity | |||
![]() | ![]() | ![]() | GO:0016725 oxidoreductase activity, acting on CH or CH2 groups | ||
![]() | ![]() | ![]() | ![]() | GO:0016728 oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor | |
![]() | ![]() | ![]() | ![]() | ![]() | GO:0004748 ribonucleoside-diphosphate reductase activity |
| Code | Relationship |
![]() | part of |
![]() | is a |
![]() | regulates |
![]() | +ve regulates |
![]() | -ve regulates |
| I | GO:0016959 class I ribonucleotide reductase activity |
| I | GO:0016960 class II ribonucleotide reductase activity |
| I | GO:0016961 class III ribonucleotide reductase activity |
| I | GO:0051061 ADP reductase activity |
| I | GO:0051062 UDP reductase activity |
| I | GO:0051063 CDP reductase activity |
| Code | Relationship |
| P | part of |
| I | is a |
| Hostname | tomcat-8.ebi.ac.uk |
| Uptime | 17:46 13/10/2009 |
| Data version | 2009-11-21-04-03-45 |