spacer

GO:0004725 protein tyrosine phosphatase activity

Term Information

ID GO:0004725
Name protein tyrosine phosphatase activity
Ontology Molecular Function
Definition Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
GONUTS GO:0004725 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact tyrosylprotein phosphatase activity
exact phosphotyrosine phosphatase activity
exact PPT-phosphatase activity
exact PTP-phosphatase activity
exact [phosphotyrosine]protein phosphatase activity
exact phosphoprotein phosphatase (phosphotyrosine) activity
exact phosphotyrosine histone phosphatase activity
exact phosphotyrosine protein phosphatase activity
exact phosphotyrosylprotein phosphatase activity
exact protein phosphotyrosine phosphatase activity
exact protein-tyrosine-phosphate phosphohydrolase activity
exact tyrosine O-phosphate phosphatase activity
exact PTPase activity
exact protein-tyrosine-phosphatase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.1.3.48
InterPro IPR000242
InterPro IPR000751
InterPro IPR003546
InterPro IPR008356
InterPro IPR008425
InterPro IPR012151
InterPro IPR012152
InterPro IPR012153
InterPro IPR012265
InterPro IPR012266
InterPro IPR014064
InterPro IPR014392
InterPro IPR015103
InterPro IPR016130
InterPro IPR016276
InterPro IPR016277
InterPro IPR016334
InterPro IPR016335
InterPro IPR016336
InterPro IPR016667
InterPro IPR017361
InterPro IPR017867
InterPro IPR020428
InterPro IPR022778
InterPro IPR027262
InterPro IPR028471
InterPro IPR028472
InterPro IPR028473
InterPro IPR028479
InterPro IPR028770
InterPro IPR030590
MetaCyc PROTEIN-TYROSINE-PHOSPHATASE-RXN

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004725:
Relationship To GO:0004725 Child Term Child Term Name
Positively regulates GO:0008160 protein tyrosine phosphatase activator activity
Is a GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
Is a GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
Is a GO:0004727 prenylated protein tyrosine phosphatase activity
Is a GO:0004728 receptor signaling protein tyrosine phosphatase activity
Is a GO:0030945 protein tyrosine phosphatase activity, via thiol-phosphate intermediate
Is a GO:0030946 protein tyrosine phosphatase activity, metal-dependent
Is a GO:0033550 MAP kinase tyrosine phosphatase activity
Capable of GO:1904096 protein tyrosine phosphatase complex
Regulates GO:1903613 regulation of protein tyrosine phosphatase activity
Negatively regulates GO:1903614 negative regulation of protein tyrosine phosphatase activity
Positively regulates GO:1903615 positive regulation of protein tyrosine phosphatase activity
Is a GO:1990439 MAP kinase threonine phosphatase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004725. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004725 based on the entire annotation set Co-occurrence statistics for GO:0004725 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-03-11 Added RELATION part of GO:0035335 (peptidyl-tyrosine dephosphorylation)
2008-05-13 Added DEFINITION Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
2008-04-01 Updated RELATION is a GO:0004721 (phosphoprotein phosphatase activity)
2007-12-14 Added SYNONYM tyrosine O-phosphate phosphatase activity
2007-12-14 Added SYNONYM tyrosylprotein phosphatase activity
2007-12-14 Added SYNONYM PPT-phosphatase activity
2007-12-14 Added SYNONYM PTP-phosphatase activity
2007-12-14 Added SYNONYM [phosphotyrosine]protein phosphatase activity
2007-12-14 Added SYNONYM phosphoprotein phosphatase (phosphotyrosine) activity
2007-12-14 Added SYNONYM phosphotyrosine histone phosphatase activity
2007-12-14 Added SYNONYM phosphotyrosine protein phosphatase activity
2007-12-14 Added SYNONYM phosphotyrosylprotein phosphatase activity
2007-12-14 Added SYNONYM protein phosphotyrosine phosphatase activity
2007-12-14 Added SYNONYM protein-tyrosine-phosphatase activity
2007-12-14 Added SYNONYM protein-tyrosine-phosphate phosphohydrolase activity
2007-10-16 Deleted SYNONYM protein tyrosine phosphatase activity
2007-09-06 Added SYNONYM PTPase activity
2007-09-06 Added SYNONYM phosphotyrosine phosphatase activity
2007-08-09 Added SYNONYM protein tyrosine phosphatase activity
2007-08-09 Deleted SYNONYM protein tyrosine phosphatase activity
2004-05-03 Updated TERM protein tyrosine phosphatase activity
2004-04-19 Added SYNONYM protein tyrosine phosphatase activity
2004-04-16 Deleted SYNONYM protein tyrosine phosphatase activity
2004-01-07 Updated TERM protein-tyrosine-phosphatase activity
2004-01-07 Added SYNONYM protein tyrosine phosphatase activity
2003-10-27 Added XREF MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN
2003-03-19 Updated TERM protein tyrosine phosphatase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
2002-02-06 Updated TERM protein tyrosine phosphatase
2001-04-03 Updated TERM protein tyrosine phosphatase
2001-03-30 Added XREF EC:3.1.3.48
2001-03-30 Added TERM protein tyrosine phosphatase

Term

Timestamp Action Category Detail
2004-05-03 Updated TERM protein tyrosine phosphatase activity
2004-01-07 Updated TERM protein-tyrosine-phosphatase activity
2003-03-19 Updated TERM protein tyrosine phosphatase activity
2002-02-06 Updated TERM protein tyrosine phosphatase
2001-04-03 Updated TERM protein tyrosine phosphatase
2001-03-30 Added TERM protein tyrosine phosphatase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
2007-12-14 Added SYNONYM tyrosine O-phosphate phosphatase activity
2007-12-14 Added SYNONYM tyrosylprotein phosphatase activity
2007-12-14 Added SYNONYM PPT-phosphatase activity
2007-12-14 Added SYNONYM PTP-phosphatase activity
2007-12-14 Added SYNONYM [phosphotyrosine]protein phosphatase activity
2007-12-14 Added SYNONYM phosphoprotein phosphatase (phosphotyrosine) activity
2007-12-14 Added SYNONYM phosphotyrosine histone phosphatase activity
2007-12-14 Added SYNONYM phosphotyrosine protein phosphatase activity
2007-12-14 Added SYNONYM phosphotyrosylprotein phosphatase activity
2007-12-14 Added SYNONYM protein phosphotyrosine phosphatase activity
2007-12-14 Added SYNONYM protein-tyrosine-phosphatase activity
2007-12-14 Added SYNONYM protein-tyrosine-phosphate phosphohydrolase activity
2007-10-16 Deleted SYNONYM protein tyrosine phosphatase activity
2007-09-06 Added SYNONYM PTPase activity
2007-09-06 Added SYNONYM phosphotyrosine phosphatase activity
2007-08-09 Added SYNONYM protein tyrosine phosphatase activity
2007-08-09 Deleted SYNONYM protein tyrosine phosphatase activity
2004-04-19 Added SYNONYM protein tyrosine phosphatase activity
2004-04-16 Deleted SYNONYM protein tyrosine phosphatase activity
2004-01-07 Added SYNONYM protein tyrosine phosphatase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Relationships

Timestamp Action Category Detail
2011-03-11 Added RELATION part of GO:0035335 (peptidyl-tyrosine dephosphorylation)
2008-04-01 Updated RELATION is a GO:0004721 (phosphoprotein phosphatase activity)

Cross-references

Timestamp Action Category Detail
2003-10-27 Added XREF MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN
2001-03-30 Added XREF EC:3.1.3.48
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
16ms