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GO:0004721 phosphoprotein phosphatase activityCatalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
Term Information
GO SlimsThis term is present in the following GO Consortium-maintained GO slims:
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| Type | Synonym |
| exact | protein phosphatase activity |
| exact | phosphoprotein phosphohydrolase activity |
| narrow | protein phosphatase-2C activity |
| narrow | protein phosphatase-2B activity |
| narrow | protein phosphatase-2A activity |
| narrow | protein phosphatase-1 activity |
| Database | ID |
| INTERPRO | IPR006945 |
| INTERPRO | IPR012008 |
| INTERPRO | IPR012391 |
| INTERPRO | IPR010822 |
| EC | 3.1.3.16 |
| MetaCyc | 3.1.3.16-RXN |
| INTERPRO | IPR011236 |
| INTERPRO | IPR012911 |
| INTERPRO | IPR006811 |
| INTERPRO | IPR011943 |
| INTERPRO | IPR011947 |
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0003674 molecular_function | ||||||
![]() | GO:0003824 catalytic activity | |||||
![]() | ![]() | GO:0016787 hydrolase activity | ||||
![]() | ![]() | ![]() | GO:0016788 hydrolase activity, acting on ester bonds | |||
![]() | ![]() | ![]() | ![]() | GO:0042578 phosphoric ester hydrolase activity | ||
![]() | ![]() | ![]() | ![]() | ![]() | GO:0016791 phosphatase activity | |
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0004721 phosphoprotein phosphatase activity |
| Code | Relationship |
![]() | part of |
![]() | is a |
![]() | regulates |
![]() | +ve regulates |
![]() | -ve regulates |
| I | GO:0008138 protein tyrosine/serine/threonine phosphatase activity |
| I | GO:0019198 transmembrane receptor protein phosphatase activity |
| I | GO:0008330 protein tyrosine/threonine phosphatase activity |
| I | GO:0004722 protein serine/threonine phosphatase activity |
| I | GO:0004725 protein tyrosine phosphatase activity |
| I | GO:0033549 MAP kinase phosphatase activity |
| Code | Relationship |
| P | part of |
| I | is a |
| Hostname | tomcat-8.ebi.ac.uk |
| Uptime | 17:46 13/10/2009 |
| Data version | 2009-11-20-04-03-08 |