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GO:0004721 phosphoprotein phosphatase activity

Term Information

ID GO:0004721
Name phosphoprotein phosphatase activity
Ontology Molecular Function
Definition Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
GONUTS GO:0004721 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow protein phosphatase-2C activity
narrow protein phosphatase-2B activity
exact phosphoprotein phosphohydrolase activity
narrow protein phosphatase-2A activity
narrow protein phosphatase-1 activity
exact protein phosphatase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.1.3.16
InterPro IPR006811
InterPro IPR008425
InterPro IPR011236
InterPro IPR011943
InterPro IPR011947
InterPro IPR012008
InterPro IPR012391
InterPro IPR012911
InterPro IPR022778
InterPro IPR026070
MetaCyc 3.1.3.16-RXN
UniProtKB-KW Protein phosphatase

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004721:
Relationship To GO:0004721 Child Term Child Term Name
Negatively regulates GO:0004864 protein phosphatase inhibitor activity
Is a GO:0008138 protein tyrosine/serine/threonine phosphatase activity
Is a GO:0019198 transmembrane receptor protein phosphatase activity
Is a GO:0008330 protein tyrosine/threonine phosphatase activity
Is a GO:0004722 protein serine/threonine phosphatase activity
Is a GO:0004725 protein tyrosine phosphatase activity
Regulates GO:0019888 protein phosphatase regulator activity
Negatively regulates GO:0032515 negative regulation of phosphoprotein phosphatase activity
Positively regulates GO:0032516 positive regulation of phosphoprotein phosphatase activity
Regulates GO:0043666 regulation of phosphoprotein phosphatase activity
Is a GO:0033549 MAP kinase phosphatase activity
Is a GO:0098627 protein arginine phosphatase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
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Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004721. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004721 based on the entire annotation set Co-occurrence statistics for GO:0004721 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-11-05 Deleted SLIM goslim_candida
2011-08-14 Deleted SLIM goslim_yeast
2010-12-05 Deleted SLIM goslim_generic
2008-06-09 Added SLIM goslim_yeast
2008-06-09 Added SLIM goslim_generic
2008-06-09 Added SLIM goslim_candida
2008-05-13 Added DEFINITION Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
2008-04-01 Updated RELATION is a GO:0016791 (phosphatase activity)
2007-12-14 Added SYNONYM phosphoprotein phosphohydrolase activity
2007-09-06 Added SYNONYM protein phosphatase-1 activity
2007-09-06 Added SYNONYM protein phosphatase-2A activity
2007-09-06 Added SYNONYM protein phosphatase-2B activity
2007-09-06 Added SYNONYM protein phosphatase-2C activity
2007-08-09 Added SYNONYM protein phosphatase activity
2007-08-09 Deleted SYNONYM protein phosphatase activity
2004-04-19 Added SYNONYM protein phosphatase activity
2004-04-16 Deleted SYNONYM protein phosphatase activity
2004-01-07 Updated TERM phosphoprotein phosphatase activity
2004-01-07 Added SYNONYM protein phosphatase activity
2003-10-27 Added XREF MetaCyc:3.1.3.16-RXN
2003-03-26 Updated DEFINITION Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
2003-03-19 Updated TERM protein phosphatase activity
2002-11-27 Updated DEFINITION Catalysis of the hydrolysis of phosphate groups from proteins. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
2002-06-12 Added XREF EC:3.1.3.16
2002-06-12 Deleted XREF EC:3.1.3.-
2002-02-06 Updated TERM protein phosphatase
2001-08-06 Added DEFINITION Any enzyme that hydrolyzes phosphate groups from proteins. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
2001-04-03 Updated TERM protein phosphatase
2001-03-30 Added XREF EC:3.1.3.-
2001-03-30 Added TERM protein phosphatase

Term

Timestamp Action Category Detail
2004-01-07 Updated TERM phosphoprotein phosphatase activity
2003-03-19 Updated TERM protein phosphatase activity
2002-02-06 Updated TERM protein phosphatase
2001-04-03 Updated TERM protein phosphatase
2001-03-30 Added TERM protein phosphatase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
2007-12-14 Added SYNONYM phosphoprotein phosphohydrolase activity
2007-09-06 Added SYNONYM protein phosphatase-1 activity
2007-09-06 Added SYNONYM protein phosphatase-2A activity
2007-09-06 Added SYNONYM protein phosphatase-2B activity
2007-09-06 Added SYNONYM protein phosphatase-2C activity
2007-08-09 Added SYNONYM protein phosphatase activity
2007-08-09 Deleted SYNONYM protein phosphatase activity
2004-04-19 Added SYNONYM protein phosphatase activity
2004-04-16 Deleted SYNONYM protein phosphatase activity
2004-01-07 Added SYNONYM protein phosphatase activity
2003-03-26 Updated DEFINITION Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
2002-11-27 Updated DEFINITION Catalysis of the hydrolysis of phosphate groups from proteins. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
2001-08-06 Added DEFINITION Any enzyme that hydrolyzes phosphate groups from proteins. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016791 (phosphatase activity)

Cross-references

Timestamp Action Category Detail
2003-10-27 Added XREF MetaCyc:3.1.3.16-RXN
2002-06-12 Added XREF EC:3.1.3.16
2002-06-12 Deleted XREF EC:3.1.3.-
2001-03-30 Added XREF EC:3.1.3.-

Other

Timestamp Action Category Detail
2011-11-05 Deleted SLIM goslim_candida
2011-08-14 Deleted SLIM goslim_yeast
2010-12-05 Deleted SLIM goslim_generic
2008-06-09 Added SLIM goslim_yeast
2008-06-09 Added SLIM goslim_generic
2008-06-09 Added SLIM goslim_candida
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