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GO:0004714 transmembrane receptor protein tyrosine kinase activity

Catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate, to initiate a change in cell activity.

Term Information

ID GO:0004714
Name transmembrane receptor protein tyrosine kinase activity
Ontology Molecular Function
Definition Catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate, to initiate a change in cell activity.
Comment

Synonyms

Type Synonym
related neurotrophin TRKB receptor activity
related neurotrophin TRKC receptor activity
exact receptor protein-tyrosine kinase activity
related sevenless receptor activity
exact receptor protein tyrosine kinase activity
broad ATP:protein-tyrosine O-phosphotransferase activity
exact ATP:protein-L-tyrosine O-phosphotransferase (receptor-type) activity
narrow Drosophila Eph kinase activity
narrow anaplastic lymphoma kinase activity
narrow ephrin-B3 receptor tyrosine kinase activity
narrow insulin receptor protein-tyrosine kinase activity
narrow neurite outgrowth regulating kinase activity
narrow novel oncogene with kinase-domain activity
related neurotrophin TRK receptor activity
related neurotrophin TRKA receptor activity

Cross-references associated with this term:

Database ID
EC 2.7.10.1
MetaCyc 2.7.10.1-RXN
INTERPRO IPR006211
INTERPRO IPR015776
INTERPRO IPR015781
INTERPRO IPR002011
INTERPRO IPR016247
INTERPRO IPR001824

This term can be used instead of these obsolete terms:

GO:0005016 neurotrophin TRKC receptor activity (consider GO:0004714)
GO:0004927 sevenless receptor activity (consider GO:0004714)
GO:0005013 neurotrophin TRK receptor activity (consider GO:0004714)
GO:0005014 neurotrophin TRKA receptor activity (consider GO:0004714)
GO:0005015 neurotrophin TRKB receptor activity (consider GO:0004714)

Web service: term information

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Ancestor Chart

Visual display of a section of the GO directed acyclic graph (DAG) for a single GO term. Terms in the GO are linked to parent (more general) terms and often to child (more specific) terms by one or more 'relationships'

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Chart

Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0060089 molecular transducer activity
GO:0016740 transferase activity
GO:0004871 signal transducer activity
GO:0004872 receptor activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0004888 transmembrane receptor activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0016301 kinase activity
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0019199 transmembrane receptor protein kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
I GO:0008288 boss receptor activity
I GO:0005003 ephrin receptor activity
I GO:0005006 epidermal growth factor receptor activity
I GO:0005007 fibroblast growth factor receptor activity
I GO:0005008 hepatocyte growth factor receptor activity
I GO:0005009 insulin receptor activity
I GO:0005010 insulin-like growth factor receptor activity
I GO:0005011 macrophage colony stimulating factor receptor activity
I GO:0005017 platelet-derived growth factor receptor activity
I GO:0005020 stem cell factor receptor activity
I GO:0005021 vascular endothelial growth factor receptor activity
I GO:0060175 brain-derived neurotrophic factor receptor activity

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

This display shows those GO terms which have been annotated to the same proteins as this term.
Terms may have been co-annotated either by electronic (IEA) or manual annotation methods. Users can decide which evidence code type should be used in the calculation of the co-occurence statistics.
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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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