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GO:0004709 MAP kinase kinase kinase activity

Term Information

ID GO:0004709
Name MAP kinase kinase kinase activity
Ontology Molecular Function
Definition Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
PMID:9561267
Secondary IDs GO:0004710
GONUTS GO:0004709 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact mitogen-activated protein kinase kinase kinase activity
related cRaf
exact MEKK activity
exact MAPK/ERK kinase kinase activity
exact ATP:protein phosphotransferase (MAPKKKK-activated) activity
related MAP3K
exact MEK kinase activity
related MEKK
related MEKK1
related MEKK2
related MEKK3
narrow MLK-like mitogen-activated protein triple kinase activity
related MLTK
related MLTKa
related MLTKb
related Mil/Raf
related REKS
related STK28
related cMos
exact MAPKKK activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000015 GO:0000165 MAPK cascade only_in_taxon 2759 Eukaryota
GOTAX:0000017 GO:0000186 activation of MAPKK activity only_in_taxon 2759 Eukaryota
More information on taxon constraints in GO is available here

Cross-references

Database ID
EC 2.7.11.-
EC 2.7.11.25
InterPro IPR015785
InterPro IPR016231
InterPro IPR017419
InterPro IPR017421
InterPro IPR017424
InterPro IPR027257
InterPro IPR027258
MetaCyc 2.7.11.25-RXN

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004709:
Relationship To GO:0004709 Child Term Child Term Name
Is a GO:0004706 JUN kinase kinase kinase activity
Positively regulates GO:0000185 activation of MAPKKK activity
Negatively regulates GO:0051390 inactivation of MAPKKK activity
Is a GO:0038070 MAP kinase kinase kinase activity involved in cell wall organization or biogenesis
Is a GO:0038073 MAP kinase kinase kinase activity involved in conjugation with cellular fusion
Is a GO:0038077 MAP kinase kinase kinase activity involved in innate immune response
Is a GO:0038081 MAP kinase kinase kinase activity involved in osmosensory signaling pathway

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004709. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004709 based on the entire annotation set Co-occurrence statistics for GO:0004709 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-05-25 Added SECONDARY GO:0004710 (MAPK/ERK kinase kinase activity)
2012-05-25 Added XREF EC:2.7.11.-
2012-05-25 Added SYNONYM MEKK activity
2012-05-25 Added SYNONYM MAPK/ERK kinase kinase activity
2012-01-29 Added DEFINITION Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
2012-01-29 Deleted DEFINITION Catalysis of the phosphorylation and activation of MAP kinase kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
2012-01-29 Added RELATION part of GO:0000186 (activation of MAPKK activity)
2012-01-29 Added RELATION part of GO:0000165 (MAPK cascade)
2009-05-21 Added XREF MetaCyc:2.7.11.25-RXN
2008-05-13 Added DEFINITION Catalysis of the phosphorylation and activation of MAP kinase kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
2008-05-12 Deleted DEFINITION Catalysis of the phosphorylation and activation of MAP kinase kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
2008-04-01 Updated RELATION is a GO:0004702 (receptor signaling protein serine/threonine kinase activity)
2007-11-08 Added SYNONYM ATP:protein phosphotransferase (MAPKKKK-activated) activity
2007-11-08 Added SYNONYM MAP3K
2007-11-08 Added SYNONYM MEK kinase activity
2007-11-08 Added SYNONYM MEKK
2007-11-08 Added SYNONYM MEKK1
2007-11-08 Added SYNONYM MEKK2
2007-11-08 Added SYNONYM MEKK3
2007-11-08 Added SYNONYM MLK-like mitogen-activated protein triple kinase activity
2007-11-08 Added SYNONYM MLTK
2007-11-08 Added SYNONYM MLTKa
2007-11-08 Added SYNONYM MLTKb
2007-11-08 Added SYNONYM Mil/Raf
2007-11-08 Added SYNONYM REKS
2007-11-08 Added SYNONYM STK28
2007-11-08 Added SYNONYM cMos
2007-11-08 Added SYNONYM cRaf
2007-11-08 Added SYNONYM mitogen-activated protein kinase kinase kinase activity
2007-11-08 Deleted SYNONYM MEK kinase activity
2007-11-08 Deleted SYNONYM MEKK activity
2007-09-26 Added XREF EC:2.7.11.25
2007-09-26 Deleted XREF EC:2.7.1.-
2007-08-09 Added SYNONYM MAPKKK activity
2007-08-09 Added SYNONYM MEK kinase activity
2007-08-09 Added SYNONYM MEKK activity
2007-08-09 Deleted SYNONYM MAPKKK activity
2007-08-09 Deleted SYNONYM MEK kinase activity
2007-08-09 Deleted SYNONYM MEKK activity
2005-07-09 Added SYNONYM MAPKKK activity
2005-07-09 Added SYNONYM MEK kinase activity
2005-07-09 Added SYNONYM MEKK activity
2005-07-09 Deleted SYNONYM MAPKKK
2005-07-09 Deleted SYNONYM MEK kinase
2005-07-09 Deleted SYNONYM MEKK
2004-04-19 Added SYNONYM MAPKKK
2004-04-19 Added SYNONYM MEK kinase
2004-04-19 Added SYNONYM MEKK
2004-04-17 Updated DEFINITION Catalysis of the phosphorylation and activation of MAP kinase kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
2004-04-16 Deleted SYNONYM MAPKKK
2004-04-16 Deleted SYNONYM MEK kinase
2004-04-16 Deleted SYNONYM MEKK
2003-04-12 Added SYNONYM MEK kinase
2003-04-12 Added SYNONYM MEKK
2003-03-19 Updated TERM MAP kinase kinase kinase activity
2002-11-27 Updated DEFINITION Catalysis of the phosphorylation and activation of MAP kinases kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
2002-02-06 Updated TERM MAP kinase kinase kinase
2001-08-06 Added DEFINITION Enzyme that phosphorylates and activates MAP kinases kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
2001-04-03 Updated TERM MAP kinase kinase kinase
2001-03-30 Added XREF EC:2.7.1.-
2001-03-30 Added SYNONYM MAPKKK
2001-03-30 Added TERM MAP kinase kinase kinase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM MAP kinase kinase kinase activity
2002-02-06 Updated TERM MAP kinase kinase kinase
2001-04-03 Updated TERM MAP kinase kinase kinase
2001-03-30 Added TERM MAP kinase kinase kinase

Definition/synonyms

Timestamp Action Category Detail
2012-05-25 Added SYNONYM MEKK activity
2012-05-25 Added SYNONYM MAPK/ERK kinase kinase activity
2012-01-29 Added DEFINITION Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
2012-01-29 Deleted DEFINITION Catalysis of the phosphorylation and activation of MAP kinase kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
2008-05-13 Added DEFINITION Catalysis of the phosphorylation and activation of MAP kinase kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
2008-05-12 Deleted DEFINITION Catalysis of the phosphorylation and activation of MAP kinase kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
2007-11-08 Added SYNONYM ATP:protein phosphotransferase (MAPKKKK-activated) activity
2007-11-08 Added SYNONYM MAP3K
2007-11-08 Added SYNONYM MEK kinase activity
2007-11-08 Added SYNONYM MEKK
2007-11-08 Added SYNONYM MEKK1
2007-11-08 Added SYNONYM MEKK2
2007-11-08 Added SYNONYM MEKK3
2007-11-08 Added SYNONYM MLK-like mitogen-activated protein triple kinase activity
2007-11-08 Added SYNONYM MLTK
2007-11-08 Added SYNONYM MLTKa
2007-11-08 Added SYNONYM MLTKb
2007-11-08 Added SYNONYM Mil/Raf
2007-11-08 Added SYNONYM REKS
2007-11-08 Added SYNONYM STK28
2007-11-08 Added SYNONYM cMos
2007-11-08 Added SYNONYM cRaf
2007-11-08 Added SYNONYM mitogen-activated protein kinase kinase kinase activity
2007-11-08 Deleted SYNONYM MEK kinase activity
2007-11-08 Deleted SYNONYM MEKK activity
2007-08-09 Added SYNONYM MAPKKK activity
2007-08-09 Added SYNONYM MEK kinase activity
2007-08-09 Added SYNONYM MEKK activity
2007-08-09 Deleted SYNONYM MAPKKK activity
2007-08-09 Deleted SYNONYM MEK kinase activity
2007-08-09 Deleted SYNONYM MEKK activity
2005-07-09 Added SYNONYM MAPKKK activity
2005-07-09 Added SYNONYM MEK kinase activity
2005-07-09 Added SYNONYM MEKK activity
2005-07-09 Deleted SYNONYM MAPKKK
2005-07-09 Deleted SYNONYM MEK kinase
2005-07-09 Deleted SYNONYM MEKK
2004-04-19 Added SYNONYM MAPKKK
2004-04-19 Added SYNONYM MEK kinase
2004-04-19 Added SYNONYM MEKK
2004-04-17 Updated DEFINITION Catalysis of the phosphorylation and activation of MAP kinase kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
2004-04-16 Deleted SYNONYM MAPKKK
2004-04-16 Deleted SYNONYM MEK kinase
2004-04-16 Deleted SYNONYM MEKK
2003-04-12 Added SYNONYM MEK kinase
2003-04-12 Added SYNONYM MEKK
2002-11-27 Updated DEFINITION Catalysis of the phosphorylation and activation of MAP kinases kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
2001-08-06 Added DEFINITION Enzyme that phosphorylates and activates MAP kinases kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
2001-03-30 Added SYNONYM MAPKKK

Relationships

Timestamp Action Category Detail
2012-01-29 Added RELATION part of GO:0000186 (activation of MAPKK activity)
2012-01-29 Added RELATION part of GO:0000165 (MAPK cascade)
2008-04-01 Updated RELATION is a GO:0004702 (receptor signaling protein serine/threonine kinase activity)

Cross-references

Timestamp Action Category Detail
2012-05-25 Added XREF EC:2.7.11.-
2009-05-21 Added XREF MetaCyc:2.7.11.25-RXN
2007-09-26 Added XREF EC:2.7.11.25
2007-09-26 Deleted XREF EC:2.7.1.-
2001-03-30 Added XREF EC:2.7.1.-

Other

Timestamp Action Category Detail
2012-05-25 Added SECONDARY GO:0004710 (MAPK/ERK kinase kinase activity)
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