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GO:0004708 MAP kinase kinase activity

Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It is a dual-specificity mitogen-activated protein kinase kinase and requires activation by the serine/threonine kinase, MAP kinase kinase kinase.

Term Information

ID GO:0004708
Name MAP kinase kinase activity
Ontology Molecular Function
Definition Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It is a dual-specificity mitogen-activated protein kinase kinase and requires activation by the serine/threonine kinase, MAP kinase kinase kinase.
Comment

Synonyms

Type Synonym
related MKK4
broad MEK activity
related MKK
related MEK2
related MEK1
related MAPKK1
related MAPKK
related MAP2K
related MAP kinase or ERK kinase activity
narrow MAP kinase kinase 7 activity
narrow MAP kinase kinase 4 activity
exact ATP:protein phosphotransferase (MAPKKK-activated) activity
exact ERK activator kinase activity
exact MAPKK activity
exact mitogen-activated protein kinase kinase activity
related STK27
related MKK7
related MKK6
related MKK2

Cross-references associated with this term:

Database ID
MetaCyc 2.7.12.2-RXN
EC 2.7.11.-

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Ancestor Table

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0004672 protein kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004708 MAP kinase kinase activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
I GO:0008545 JUN kinase kinase activity

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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