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GO:0004708 MAP kinase kinase activity

Term Information

ID GO:0004708
Name MAP kinase kinase activity
Ontology Molecular Function
Definition Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
GONUTS GO:0004708 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related STK27
exact mitogen-activated protein kinase kinase activity
related MKK6
related MKK4
related MKK2
related MKK
related MEK1
related MAPKK1
related MAPKK
related MAP2K
related MAP kinase or ERK kinase activity
narrow MAP kinase kinase 7 activity
narrow MAP kinase kinase 4 activity
exact ATP:protein phosphotransferase (MAPKKK-activated) activity
related MEK2
exact ERK activator kinase activity
exact MAPK activator activity
broad MEK activity
exact MAPKK activity
related MKK7

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000015 GO:0000165 MAPK cascade only_in_taxon 2759 Eukaryota
More information on taxon constraints in GO is available here

Cross-references

Database ID
EC 2.7.11.-
MetaCyc 2.7.12.2-RXN

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004708:
Relationship To GO:0004708 Child Term Child Term Name
Is a GO:0008545 JUN kinase kinase activity
Positively regulates GO:0000186 activation of MAPKK activity
Negatively regulates GO:0051389 inactivation of MAPKK activity
Is a GO:0038068 MAP kinase kinase activity involved in cell wall organization or biogenesis
Is a GO:0038072 MAP kinase kinase activity involved in conjugation with cellular fusion
Is a GO:0038076 MAP kinase kinase activity involved in innate immune response
Is a GO:0038080 MAP kinase kinase activity involved in osmosensory signaling pathway

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004708. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004708 based on the entire annotation set Co-occurrence statistics for GO:0004708 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-10-30 Added SYNONYM MAPK activator activity
2012-01-29 Added RELATION part of GO:0000187 (activation of MAPK activity)
2012-01-29 Added RELATION part of GO:0000165 (MAPK cascade)
2012-01-29 Deleted DEFINITION Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It is a dual-specificity mitogen-activated protein kinase kinase and requires activation by the serine/threonine kinase, MAP kinase kinase kinase.
2012-01-29 Added DEFINITION Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
2009-05-21 Added XREF MetaCyc:2.7.12.2-RXN
2008-05-13 Added DEFINITION Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It is a dual-specificity mitogen-activated protein kinase kinase and requires activation by the serine/threonine kinase, MAP kinase kinase kinase.
2008-05-12 Deleted DEFINITION Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It is a dual-specificity mitogen-activated protein kinase kinase and requires activation by the serine/threonine kinase, MAP kinase kinase kinase.
2008-04-01 Updated RELATION is a GO:0004712 (protein serine/threonine/tyrosine kinase activity)
2007-09-26 Added XREF EC:2.7.11.-
2007-09-26 Deleted XREF EC:2.7.1.-
2007-09-26 Added SYNONYM ATP:protein phosphotransferase (MAPKKK-activated) activity
2007-09-26 Added SYNONYM MAP kinase kinase 4 activity
2007-09-26 Added SYNONYM MAP kinase kinase 7 activity
2007-09-26 Added SYNONYM MAP kinase or ERK kinase activity
2007-09-26 Added SYNONYM MAP2K
2007-09-26 Added SYNONYM MAPKK
2007-09-26 Added SYNONYM MAPKK1
2007-09-26 Added SYNONYM MEK1
2007-09-26 Added SYNONYM MEK2
2007-09-26 Added SYNONYM MKK
2007-09-26 Added SYNONYM MKK2
2007-09-26 Added SYNONYM MKK4
2007-09-26 Added SYNONYM MKK6
2007-09-26 Added SYNONYM MKK7
2007-09-26 Added SYNONYM STK27
2007-09-26 Added SYNONYM mitogen-activated protein kinase kinase activity
2007-08-09 Added SYNONYM ERK activator kinase activity
2007-08-09 Added SYNONYM MAPKK activity
2007-08-09 Added SYNONYM MEK activity
2007-08-09 Deleted SYNONYM ERK activator kinase activity
2007-08-09 Deleted SYNONYM MAPKK activity
2007-08-09 Deleted SYNONYM MEK activity
2005-07-09 Added SYNONYM ERK activator kinase activity
2005-07-09 Added SYNONYM MAPKK activity
2005-07-09 Added SYNONYM MEK activity
2005-07-09 Deleted SYNONYM MEK
2005-07-09 Deleted SYNONYM ERK activator kinase
2005-07-09 Deleted SYNONYM MAPKK
2004-04-19 Added SYNONYM ERK activator kinase
2004-04-19 Added SYNONYM MAPKK
2004-04-16 Deleted SYNONYM ERK activator kinase
2004-04-16 Deleted SYNONYM MAPKK
2003-08-05 Updated DEFINITION Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It is a dual-specificity mitogen-activated protein kinase kinase and requires activation by the serine/threonine kinase, MAP kinase kinase kinase.
2003-04-12 Deleted SYNONYM extracellular signal-regulated kinase
2003-03-19 Updated TERM MAP kinase kinase activity
2003-03-19 Added SYNONYM MEK
2002-11-27 Updated DEFINITION A dual-specificity mitogen-activated protein kinase kinase; an enzyme that catalyzes the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It requires activation by the serine/threonine kinase, MAP kinase kinase kinase.
2002-02-06 Updated TERM MAP kinase kinase
2001-08-06 Added DEFINITION A dual-specificity mitogen-activated protein kinase kinase; an enzyme that catalyzes the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a TEY sequence in MAP kinases. It requires activation by the serine/threonine kinase, MAP kinase kinase kinase.
2001-04-03 Updated TERM MAP kinase kinase
2001-03-30 Added XREF EC:2.7.1.-
2001-03-30 Added SYNONYM ERK activator kinase
2001-03-30 Added SYNONYM MAPKK
2001-03-30 Added SYNONYM extracellular signal-regulated kinase
2001-03-30 Added TERM MAP kinase kinase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM MAP kinase kinase activity
2002-02-06 Updated TERM MAP kinase kinase
2001-04-03 Updated TERM MAP kinase kinase
2001-03-30 Added TERM MAP kinase kinase

Definition/synonyms

Timestamp Action Category Detail
2013-10-30 Added SYNONYM MAPK activator activity
2012-01-29 Deleted DEFINITION Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It is a dual-specificity mitogen-activated protein kinase kinase and requires activation by the serine/threonine kinase, MAP kinase kinase kinase.
2012-01-29 Added DEFINITION Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
2008-05-13 Added DEFINITION Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It is a dual-specificity mitogen-activated protein kinase kinase and requires activation by the serine/threonine kinase, MAP kinase kinase kinase.
2008-05-12 Deleted DEFINITION Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It is a dual-specificity mitogen-activated protein kinase kinase and requires activation by the serine/threonine kinase, MAP kinase kinase kinase.
2007-09-26 Added SYNONYM ATP:protein phosphotransferase (MAPKKK-activated) activity
2007-09-26 Added SYNONYM MAP kinase kinase 4 activity
2007-09-26 Added SYNONYM MAP kinase kinase 7 activity
2007-09-26 Added SYNONYM MAP kinase or ERK kinase activity
2007-09-26 Added SYNONYM MAP2K
2007-09-26 Added SYNONYM MAPKK
2007-09-26 Added SYNONYM MAPKK1
2007-09-26 Added SYNONYM MEK1
2007-09-26 Added SYNONYM MEK2
2007-09-26 Added SYNONYM MKK
2007-09-26 Added SYNONYM MKK2
2007-09-26 Added SYNONYM MKK4
2007-09-26 Added SYNONYM MKK6
2007-09-26 Added SYNONYM MKK7
2007-09-26 Added SYNONYM STK27
2007-09-26 Added SYNONYM mitogen-activated protein kinase kinase activity
2007-08-09 Added SYNONYM ERK activator kinase activity
2007-08-09 Added SYNONYM MAPKK activity
2007-08-09 Added SYNONYM MEK activity
2007-08-09 Deleted SYNONYM ERK activator kinase activity
2007-08-09 Deleted SYNONYM MAPKK activity
2007-08-09 Deleted SYNONYM MEK activity
2005-07-09 Added SYNONYM ERK activator kinase activity
2005-07-09 Added SYNONYM MAPKK activity
2005-07-09 Added SYNONYM MEK activity
2005-07-09 Deleted SYNONYM MEK
2005-07-09 Deleted SYNONYM ERK activator kinase
2005-07-09 Deleted SYNONYM MAPKK
2004-04-19 Added SYNONYM ERK activator kinase
2004-04-19 Added SYNONYM MAPKK
2004-04-16 Deleted SYNONYM ERK activator kinase
2004-04-16 Deleted SYNONYM MAPKK
2003-08-05 Updated DEFINITION Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It is a dual-specificity mitogen-activated protein kinase kinase and requires activation by the serine/threonine kinase, MAP kinase kinase kinase.
2003-04-12 Deleted SYNONYM extracellular signal-regulated kinase
2003-03-19 Added SYNONYM MEK
2002-11-27 Updated DEFINITION A dual-specificity mitogen-activated protein kinase kinase; an enzyme that catalyzes the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It requires activation by the serine/threonine kinase, MAP kinase kinase kinase.
2001-08-06 Added DEFINITION A dual-specificity mitogen-activated protein kinase kinase; an enzyme that catalyzes the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a TEY sequence in MAP kinases. It requires activation by the serine/threonine kinase, MAP kinase kinase kinase.
2001-03-30 Added SYNONYM ERK activator kinase
2001-03-30 Added SYNONYM MAPKK
2001-03-30 Added SYNONYM extracellular signal-regulated kinase

Relationships

Timestamp Action Category Detail
2012-01-29 Added RELATION part of GO:0000187 (activation of MAPK activity)
2012-01-29 Added RELATION part of GO:0000165 (MAPK cascade)
2008-04-01 Updated RELATION is a GO:0004712 (protein serine/threonine/tyrosine kinase activity)

Cross-references

Timestamp Action Category Detail
2009-05-21 Added XREF MetaCyc:2.7.12.2-RXN
2007-09-26 Added XREF EC:2.7.11.-
2007-09-26 Deleted XREF EC:2.7.1.-
2001-03-30 Added XREF EC:2.7.1.-
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