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GO:0004708 MAP kinase kinase activityCatalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It is a dual-specificity mitogen-activated protein kinase kinase and requires activation by the serine/threonine kinase, MAP kinase kinase kinase.
Term Information
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| Type | Synonym |
| related | MKK4 |
| broad | MEK activity |
| related | MKK |
| related | MEK2 |
| related | MEK1 |
| related | MAPKK1 |
| related | MAPKK |
| related | MAP2K |
| related | MAP kinase or ERK kinase activity |
| narrow | MAP kinase kinase 7 activity |
| narrow | MAP kinase kinase 4 activity |
| exact | ATP:protein phosphotransferase (MAPKKK-activated) activity |
| exact | ERK activator kinase activity |
| exact | MAPKK activity |
| exact | mitogen-activated protein kinase kinase activity |
| related | STK27 |
| related | MKK7 |
| related | MKK6 |
| related | MKK2 |
| Database | ID |
| MetaCyc | 2.7.12.2-RXN |
| EC | 2.7.11.- |
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0003674 molecular_function | ||||||||
![]() | GO:0003824 catalytic activity | |||||||
![]() | ![]() | GO:0016740 transferase activity | ||||||
![]() | ![]() | ![]() | GO:0016772 transferase activity, transferring phosphorus-containing groups | |||||
![]() | ![]() | ![]() | ![]() | GO:0016301 kinase activity | ||||
![]() | ![]() | ![]() | ![]() | ![]() | GO:0016773 phosphotransferase activity, alcohol group as acceptor | |||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0004672 protein kinase activity | ||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0004712 protein serine/threonine/tyrosine kinase activity | |
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0004708 MAP kinase kinase activity |
| Code | Relationship |
![]() | part of |
![]() | is a |
![]() | regulates |
![]() | +ve regulates |
![]() | -ve regulates |
| I | GO:0008545 JUN kinase kinase activity |
| Code | Relationship |
| P | part of |
| I | is a |
| Hostname | tomcat-7.ebi.ac.uk |
| Uptime | 16:38 12/10/2009 |
| Data version | 2009-11-22-04-02-35 |