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GO:0004707 MAP kinase activityCatalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
Term Information
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| Type | Synonym |
| related | pp44mapk |
| related | pp42 |
| related | p44mpk |
| narrow | p42 mitogen-activated protein kinase activity |
| related | p42mapk |
| related | p38delta |
| related | p38-2 |
| narrow | myelin basic protein kinase activity |
| exact | mitogen-activated protein kinase activity |
| exact | mitogen activated kinase activity |
| narrow | extracellular signal-regulated kinase activity |
| related | STK26 |
| related | PMK-3 |
| related | PMK-2 |
| related | PMK-1 |
| narrow | MBP kinase II activity |
| narrow | MBP kinase I activity |
| related | MAPK |
| narrow | MAP-2 kinase activity |
| related | LeMPK3 |
| related | ERK |
| related | Dp38 |
| exact | ATP:protein phosphotransferase (MAPKK-activated) activity |
| Database | ID |
| INTERPRO | IPR008352 |
| INTERPRO | IPR008351 |
| INTERPRO | IPR008350 |
| INTERPRO | IPR003527 |
| MetaCyc | 2.7.11.24-RXN |
| EC | 2.7.11.24 |
| INTERPRO | IPR008349 |
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0003674 molecular_function | ||||||||||||
![]() | GO:0003824 catalytic activity | |||||||||||
![]() | ![]() | GO:0060089 molecular transducer activity | ||||||||||
![]() | ![]() | ![]() | GO:0016740 transferase activity | |||||||||
![]() | ![]() | ![]() | ![]() | GO:0004871 signal transducer activity | ||||||||
![]() | ![]() | ![]() | ![]() | ![]() | GO:0005057 receptor signaling protein activity | |||||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0016772 transferase activity, transferring phosphorus-containing groups | ||||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0016301 kinase activity | |||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0016773 phosphotransferase activity, alcohol group as acceptor | ||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0004672 protein kinase activity | |||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0004674 protein serine/threonine kinase activity | ||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0004702 receptor signaling protein serine/threonine kinase activity | |
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0004707 MAP kinase activity |
| Code | Relationship |
![]() | part of |
![]() | is a |
![]() | regulates |
![]() | +ve regulates |
![]() | -ve regulates |
| I | GO:0016908 MAP kinase 2 activity |
| I | GO:0008338 MAP kinase 1 activity |
| I | GO:0016909 SAP kinase activity |
| Code | Relationship |
| P | part of |
| I | is a |
| Hostname | tomcat-8.ebi.ac.uk |
| Uptime | 17:46 13/10/2009 |
| Data version | 2009-11-21-04-03-45 |