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GO:0004707 MAP kinase activity

Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.

Term Information

ID GO:0004707
Name MAP kinase activity
Ontology Molecular Function
Definition Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
Comment

Synonyms

Type Synonym
related pp44mapk
related pp42
related p44mpk
narrow p42 mitogen-activated protein kinase activity
related p42mapk
related p38delta
related p38-2
narrow myelin basic protein kinase activity
exact mitogen-activated protein kinase activity
exact mitogen activated kinase activity
narrow extracellular signal-regulated kinase activity
related STK26
related PMK-3
related PMK-2
related PMK-1
narrow MBP kinase II activity
narrow MBP kinase I activity
related MAPK
narrow MAP-2 kinase activity
related LeMPK3
related ERK
related Dp38
exact ATP:protein phosphotransferase (MAPKK-activated) activity

Cross-references associated with this term:

Database ID
INTERPRO IPR008352
INTERPRO IPR008351
INTERPRO IPR008350
INTERPRO IPR003527
MetaCyc 2.7.11.24-RXN
EC 2.7.11.24
INTERPRO IPR008349

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Ancestor Chart

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Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0060089 molecular transducer activity
GO:0016740 transferase activity
GO:0004871 signal transducer activity
GO:0005057 receptor signaling protein activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0004707 MAP kinase activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
I GO:0016908 MAP kinase 2 activity
I GO:0008338 MAP kinase 1 activity
I GO:0016909 SAP kinase activity

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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