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GO:0004693 cyclin-dependent protein serine/threonine kinase activity

Term Information

ID GO:0004693
Name cyclin-dependent protein serine/threonine kinase activity
Ontology Molecular Function
Definition Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
PMID:7877684 PMID:9841670
Secondary IDs GO:0016537
GONUTS GO:0004693 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow D-type cyclin kinase activity
narrow cdc2 kinase activity
exact cdk-activating kinase activity
narrow cyclin D-cdk6 kinase activity
narrow cyclin D-dependent kinase activity
narrow cyclin E kinase activity
narrow cyclin-A associated kinase activity
narrow cyclin-dependent kinase 6 activity
broad cyclin-dependent kinase activity
narrow cyclin-dependent kinase-2 activity
narrow cyclin-dependent kinase-4 activity
narrow neuronal cdc2-like kinase activity
broad cyclin-dependent protein kinase activity
exact CDK activity
exact CDK, catalytic subunit activity
exact cyclin-dependent protein kinase, intrinsic catalyst activity
exact ATP:cyclin phosphotransferase activity
related CDK
exact Cdk-activating protein kinase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 2.7.11.22
InterPro IPR028788
MetaCyc 2.7.11.22-RXN

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004693:
Relationship To GO:0004693 Child Term Child Term Name
Negatively regulates GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
Regulates GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
Regulates GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
Negatively regulates GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
Positively regulates GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
Positively regulates GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
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Date
Assigned By
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Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004693. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004693 based on the entire annotation set Co-occurrence statistics for GO:0004693 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-03-23 Deleted RELATION part of GO:0007049 (cell cycle)
2013-03-08 Added SYNONYM cyclin-dependent protein kinase activity
2013-03-08 Updated TERM cyclin-dependent protein serine/threonine kinase activity
2013-03-08 Added DEFINITION Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
2013-03-08 Deleted DEFINITION Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
2013-03-08 Added RELATION is a GO:0097472 (cyclin-dependent protein kinase activity)
2010-09-24 Deleted DEFINITION Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
2010-09-24 Added DEFINITION Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
2010-06-15 Added RELATION part of GO:0007049 (cell cycle)
2010-06-14 Deleted RELATION part of GO:0007049 (cell cycle)
2010-06-09 Updated TERM cyclin-dependent protein kinase activity
2010-06-08 Added RELATION part of GO:0007049 (cell cycle)
2010-06-08 Updated TERM cyclin-dependent protein kinase activity
2009-07-23 Deleted SYNONYM Cdk2
2009-07-23 Deleted SYNONYM cdk8
2009-07-23 Deleted SYNONYM cdk5
2009-07-23 Deleted SYNONYM STK25
2009-07-23 Deleted SYNONYM cdc2
2009-07-23 Deleted SYNONYM cdk3
2009-07-23 Deleted SYNONYM Bur1 Cdk
2009-07-23 Deleted SYNONYM nclk
2009-07-23 Deleted SYNONYM cdk2
2009-07-23 Deleted SYNONYM cdk4
2009-07-23 Deleted SYNONYM Cak1p
2009-07-23 Deleted SYNONYM cdk7
2009-07-23 Deleted SYNONYM cdk9
2009-07-23 Deleted SYNONYM Bur1
2009-07-23 Deleted SYNONYM Cdc28p
2009-07-23 Deleted SYNONYM cyclin A-activated cdk2
2009-07-23 Deleted SYNONYM cdk6
2009-07-23 Deleted SYNONYM PCTAIRE-1
2009-07-23 Deleted SYNONYM cyk
2009-07-23 Deleted SYNONYM Cak1
2009-07-23 Deleted SYNONYM cdk1
2009-07-23 Deleted SYNONYM cyclin A-activated cdc2
2009-05-21 Added XREF MetaCyc:2.7.11.22-RXN
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
2008-04-01 Updated RELATION is a GO:0004674 (protein serine/threonine kinase activity)
2007-11-08 Added SYNONYM Cdc28p
2007-11-08 Added SYNONYM Cdk-activating protein kinase activity
2007-11-08 Added SYNONYM Cdk2
2007-11-08 Added SYNONYM D-type cyclin kinase activity
2007-11-08 Added SYNONYM PCTAIRE-1
2007-11-08 Added SYNONYM STK25
2007-11-08 Added SYNONYM cdc2
2007-11-08 Added SYNONYM cdc2 kinase activity
2007-11-08 Added SYNONYM cdk-activating kinase activity
2007-11-08 Added SYNONYM cdk1
2007-11-08 Added SYNONYM cdk2
2007-11-08 Added SYNONYM cdk3
2007-11-08 Added SYNONYM cdk4
2007-11-08 Added SYNONYM cdk5
2007-11-08 Added SYNONYM cdk6
2007-11-08 Added SYNONYM cdk7
2007-11-08 Added SYNONYM cdk8
2007-11-08 Added SYNONYM cdk9
2007-11-08 Added SYNONYM cyclin A-activated cdc2
2007-11-08 Added SYNONYM cyclin A-activated cdk2
2007-11-08 Added SYNONYM cyclin D-cdk6 kinase activity
2007-11-08 Added SYNONYM cyclin D-dependent kinase activity
2007-11-08 Added SYNONYM cyclin E kinase activity
2007-11-08 Added SYNONYM cyclin-A associated kinase activity
2007-11-08 Added SYNONYM cyclin-dependent kinase 6 activity
2007-11-08 Added SYNONYM cyclin-dependent kinase activity
2007-11-08 Added SYNONYM cyclin-dependent kinase-2 activity
2007-11-08 Added SYNONYM cyclin-dependent kinase-4 activity
2007-11-08 Added SYNONYM cyk
2007-11-08 Added SYNONYM nclk
2007-11-08 Added SYNONYM neuronal cdc2-like kinase activity
2007-11-08 Added SYNONYM ATP:cyclin phosphotransferase activity
2007-11-08 Added SYNONYM Bur1
2007-11-08 Added SYNONYM Bur1 Cdk
2007-11-08 Added SYNONYM CDK
2007-11-08 Added SYNONYM Cak1
2007-11-08 Added SYNONYM Cak1p
2007-09-26 Added XREF EC:2.7.11.22
2007-09-26 Deleted XREF EC:2.7.1.-
2007-08-09 Added SYNONYM CDK activity
2007-08-09 Added SYNONYM CDK, catalytic subunit activity
2007-08-09 Added SYNONYM cyclin-dependent protein kinase, intrinsic catalyst activity
2007-08-09 Deleted SYNONYM CDK activity
2007-08-09 Deleted SYNONYM CDK, catalytic subunit activity
2007-08-09 Deleted SYNONYM cyclin-dependent protein kinase, intrinsic catalyst activity
2006-01-24 Updated DEFINITION Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
2005-07-09 Deleted SYNONYM CDK, catalytic subunit
2005-07-09 Deleted SYNONYM CDK
2005-07-09 Added SYNONYM CDK activity
2005-07-09 Added SYNONYM CDK, catalytic subunit activity
2004-04-19 Added SYNONYM CDK
2004-04-19 Added SYNONYM cyclin-dependent protein kinase, intrinsic catalyst activity
2004-04-17 Updated DEFINITION Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, where activity is dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
2004-04-16 Deleted SYNONYM CDK
2004-04-16 Deleted SYNONYM cyclin-dependent protein kinase, intrinsic catalyst activity
2004-04-15 Added DEFINITION Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, where activity is dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)
2003-12-20 Added SYNONYM CDK, catalytic subunit
2003-12-20 Added SYNONYM cyclin-dependent protein kinase, intrinsic catalyst activity
2003-12-20 Added SECONDARY GO:0016537 (cyclin-dependent protein kinase, intrinsic catalyst activity)
2003-03-19 Updated TERM cyclin-dependent protein kinase activity
2002-02-14 Added SYNONYM CDK
2002-02-06 Updated TERM cyclin-dependent protein kinase
2001-04-03 Updated TERM cyclin-dependent protein kinase
2001-03-30 Added XREF EC:2.7.1.-
2001-03-30 Added TERM cyclin-dependent protein kinase

Term

Timestamp Action Category Detail
2013-03-08 Updated TERM cyclin-dependent protein serine/threonine kinase activity
2010-06-09 Updated TERM cyclin-dependent protein kinase activity
2010-06-08 Updated TERM cyclin-dependent protein kinase activity
2003-03-19 Updated TERM cyclin-dependent protein kinase activity
2002-02-06 Updated TERM cyclin-dependent protein kinase
2001-04-03 Updated TERM cyclin-dependent protein kinase
2001-03-30 Added TERM cyclin-dependent protein kinase

Definition/synonyms

Timestamp Action Category Detail
2013-03-08 Added SYNONYM cyclin-dependent protein kinase activity
2013-03-08 Added DEFINITION Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
2013-03-08 Deleted DEFINITION Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
2010-09-24 Deleted DEFINITION Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
2010-09-24 Added DEFINITION Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
2009-07-23 Deleted SYNONYM Cdk2
2009-07-23 Deleted SYNONYM cdk8
2009-07-23 Deleted SYNONYM cdk5
2009-07-23 Deleted SYNONYM STK25
2009-07-23 Deleted SYNONYM cdc2
2009-07-23 Deleted SYNONYM cdk3
2009-07-23 Deleted SYNONYM Bur1 Cdk
2009-07-23 Deleted SYNONYM nclk
2009-07-23 Deleted SYNONYM cdk2
2009-07-23 Deleted SYNONYM cdk4
2009-07-23 Deleted SYNONYM Cak1p
2009-07-23 Deleted SYNONYM cdk7
2009-07-23 Deleted SYNONYM cdk9
2009-07-23 Deleted SYNONYM Bur1
2009-07-23 Deleted SYNONYM Cdc28p
2009-07-23 Deleted SYNONYM cyclin A-activated cdk2
2009-07-23 Deleted SYNONYM cdk6
2009-07-23 Deleted SYNONYM PCTAIRE-1
2009-07-23 Deleted SYNONYM cyk
2009-07-23 Deleted SYNONYM Cak1
2009-07-23 Deleted SYNONYM cdk1
2009-07-23 Deleted SYNONYM cyclin A-activated cdc2
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
2007-11-08 Added SYNONYM Cdc28p
2007-11-08 Added SYNONYM Cdk-activating protein kinase activity
2007-11-08 Added SYNONYM Cdk2
2007-11-08 Added SYNONYM D-type cyclin kinase activity
2007-11-08 Added SYNONYM PCTAIRE-1
2007-11-08 Added SYNONYM STK25
2007-11-08 Added SYNONYM cdc2
2007-11-08 Added SYNONYM cdc2 kinase activity
2007-11-08 Added SYNONYM cdk-activating kinase activity
2007-11-08 Added SYNONYM cdk1
2007-11-08 Added SYNONYM cdk2
2007-11-08 Added SYNONYM cdk3
2007-11-08 Added SYNONYM cdk4
2007-11-08 Added SYNONYM cdk5
2007-11-08 Added SYNONYM cdk6
2007-11-08 Added SYNONYM cdk7
2007-11-08 Added SYNONYM cdk8
2007-11-08 Added SYNONYM cdk9
2007-11-08 Added SYNONYM cyclin A-activated cdc2
2007-11-08 Added SYNONYM cyclin A-activated cdk2
2007-11-08 Added SYNONYM cyclin D-cdk6 kinase activity
2007-11-08 Added SYNONYM cyclin D-dependent kinase activity
2007-11-08 Added SYNONYM cyclin E kinase activity
2007-11-08 Added SYNONYM cyclin-A associated kinase activity
2007-11-08 Added SYNONYM cyclin-dependent kinase 6 activity
2007-11-08 Added SYNONYM cyclin-dependent kinase activity
2007-11-08 Added SYNONYM cyclin-dependent kinase-2 activity
2007-11-08 Added SYNONYM cyclin-dependent kinase-4 activity
2007-11-08 Added SYNONYM cyk
2007-11-08 Added SYNONYM nclk
2007-11-08 Added SYNONYM neuronal cdc2-like kinase activity
2007-11-08 Added SYNONYM ATP:cyclin phosphotransferase activity
2007-11-08 Added SYNONYM Bur1
2007-11-08 Added SYNONYM Bur1 Cdk
2007-11-08 Added SYNONYM CDK
2007-11-08 Added SYNONYM Cak1
2007-11-08 Added SYNONYM Cak1p
2007-08-09 Added SYNONYM CDK activity
2007-08-09 Added SYNONYM CDK, catalytic subunit activity
2007-08-09 Added SYNONYM cyclin-dependent protein kinase, intrinsic catalyst activity
2007-08-09 Deleted SYNONYM CDK activity
2007-08-09 Deleted SYNONYM CDK, catalytic subunit activity
2007-08-09 Deleted SYNONYM cyclin-dependent protein kinase, intrinsic catalyst activity
2006-01-24 Updated DEFINITION Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
2005-07-09 Deleted SYNONYM CDK, catalytic subunit
2005-07-09 Deleted SYNONYM CDK
2005-07-09 Added SYNONYM CDK activity
2005-07-09 Added SYNONYM CDK, catalytic subunit activity
2004-04-19 Added SYNONYM CDK
2004-04-19 Added SYNONYM cyclin-dependent protein kinase, intrinsic catalyst activity
2004-04-17 Updated DEFINITION Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, where activity is dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK).
2004-04-16 Deleted SYNONYM CDK
2004-04-16 Deleted SYNONYM cyclin-dependent protein kinase, intrinsic catalyst activity
2004-04-15 Added DEFINITION Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, where activity is dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)
2003-12-20 Added SYNONYM CDK, catalytic subunit
2003-12-20 Added SYNONYM cyclin-dependent protein kinase, intrinsic catalyst activity
2002-02-14 Added SYNONYM CDK

Relationships

Timestamp Action Category Detail
2013-03-23 Deleted RELATION part of GO:0007049 (cell cycle)
2013-03-08 Added RELATION is a GO:0097472 (cyclin-dependent protein kinase activity)
2010-06-15 Added RELATION part of GO:0007049 (cell cycle)
2010-06-14 Deleted RELATION part of GO:0007049 (cell cycle)
2010-06-08 Added RELATION part of GO:0007049 (cell cycle)
2008-04-01 Updated RELATION is a GO:0004674 (protein serine/threonine kinase activity)

Cross-references

Timestamp Action Category Detail
2009-05-21 Added XREF MetaCyc:2.7.11.22-RXN
2007-09-26 Added XREF EC:2.7.11.22
2007-09-26 Deleted XREF EC:2.7.1.-
2001-03-30 Added XREF EC:2.7.1.-

Other

Timestamp Action Category Detail
2003-12-20 Added SECONDARY GO:0016537 (cyclin-dependent protein kinase, intrinsic catalyst activity)
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