spacer

GO:0004666 prostaglandin-endoperoxide synthase activity

Term Information

ID GO:0004666
Name prostaglandin-endoperoxide synthase activity
Ontology Molecular Function
Definition Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O.
GONUTS GO:0004666 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact prostaglandin endoperoxide synthetase activity
exact prostaglandin synthetase activity
exact (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity
exact prostaglandin G/H synthase activity
exact PG synthetase activity
exact (PG)H synthase activity
exact fatty acid cyclooxygenase activity
exact prostaglandin synthase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.14.99.1
InterPro IPR029576
InterPro IPR029580
MetaCyc PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN
RHEA 23731

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004666:
Relationship To GO:0004666 Child Term Child Term Name
Regulates GO:0060584 regulation of prostaglandin-endoperoxide synthase activity
Positively regulates GO:0060585 positive regulation of prostaglandin-endoperoxide synthase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004666. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004666 based on the entire annotation set Co-occurrence statistics for GO:0004666 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:23731
2008-05-13 Added DEFINITION Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O.
2008-04-01 Updated RELATION is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
2007-11-08 Added SYNONYM (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity
2007-11-08 Added SYNONYM (PG)H synthase activity
2007-11-08 Added SYNONYM fatty acid cyclooxygenase activity
2007-11-08 Added SYNONYM prostaglandin endoperoxide synthetase activity
2007-09-06 Added SYNONYM PG synthetase activity
2007-09-06 Added SYNONYM prostaglandin G/H synthase activity
2007-09-06 Added SYNONYM prostaglandin synthase activity
2007-09-06 Added SYNONYM prostaglandin synthetase activity
2003-10-27 Added XREF MetaCyc:PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN
2003-08-22 Updated DEFINITION Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O.
2003-03-19 Updated TERM prostaglandin-endoperoxide synthase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O.
2002-02-06 Updated TERM prostaglandin-endoperoxide synthase
2001-04-03 Updated TERM prostaglandin-endoperoxide synthase
2001-03-30 Added XREF EC:1.14.99.1
2001-03-30 Added TERM prostaglandin-endoperoxide synthase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM prostaglandin-endoperoxide synthase activity
2002-02-06 Updated TERM prostaglandin-endoperoxide synthase
2001-04-03 Updated TERM prostaglandin-endoperoxide synthase
2001-03-30 Added TERM prostaglandin-endoperoxide synthase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O.
2007-11-08 Added SYNONYM (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity
2007-11-08 Added SYNONYM (PG)H synthase activity
2007-11-08 Added SYNONYM fatty acid cyclooxygenase activity
2007-11-08 Added SYNONYM prostaglandin endoperoxide synthetase activity
2007-09-06 Added SYNONYM PG synthetase activity
2007-09-06 Added SYNONYM prostaglandin G/H synthase activity
2007-09-06 Added SYNONYM prostaglandin synthase activity
2007-09-06 Added SYNONYM prostaglandin synthetase activity
2003-08-22 Updated DEFINITION Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O.
2002-11-27 Added DEFINITION Catalysis of the reaction: arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)

Cross-references

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:23731
2003-10-27 Added XREF MetaCyc:PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN
2001-03-30 Added XREF EC:1.14.99.1
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
24ms