spacer

GO:0004663 Rab geranylgeranyltransferase activity

Term Information

ID GO:0004663
Name Rab geranylgeranyltransferase activity
Ontology Molecular Function
Definition Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.
PMID:8621375
GONUTS GO:0004663 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact Rab-protein geranylgeranyltransferase activity
exact type II protein geranyl-geranyltransferase activity
exact geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
exact protein geranylgeranyltransferase type II activity
exact RabGGTase activity
exact GGTaseII activity
exact GGTase-II activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 2.5.1.60
InterPro IPR001738
InterPro IPR009087
InterPro IPR026873
MetaCyc 2.5.1.60-RXN
MetaCyc RXN-3701

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004663:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004663. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004663 based on the entire annotation set Co-occurrence statistics for GO:0004663 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2009-06-11 Deleted XREF MetaCyc:NULL
2009-05-21 Updated TERM Rab geranylgeranyltransferase activity
2009-05-21 Deleted SYNONYM Rab geranylgeranyltransferase activity
2009-05-21 Added SYNONYM Rab-protein geranylgeranyltransferase activity
2009-05-21 Added XREF MetaCyc:RXN-3701
2009-05-21 Added XREF MetaCyc:NULL
2009-05-21 Added XREF MetaCyc:2.5.1.60-RXN
2008-05-13 Added DEFINITION Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.
2008-04-01 Updated RELATION is a GO:0004661 (protein geranylgeranyltransferase activity)
2007-09-06 Added SYNONYM type II protein geranyl-geranyltransferase activity
2007-08-09 Added SYNONYM RabGGTase activity
2007-08-09 Added SYNONYM geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
2007-08-09 Added SYNONYM protein geranylgeranyltransferase type II activity
2007-08-09 Added SYNONYM GGTase-II activity
2007-08-09 Added SYNONYM GGTaseII activity
2007-08-09 Added SYNONYM Rab geranylgeranyltransferase activity
2007-08-09 Deleted SYNONYM GGTase-II activity
2007-08-09 Deleted SYNONYM GGTaseII activity
2007-08-09 Deleted SYNONYM Rab geranylgeranyltransferase activity
2007-08-09 Deleted SYNONYM RabGGTase activity
2007-08-09 Deleted SYNONYM geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
2007-08-09 Deleted SYNONYM protein geranylgeranyltransferase type II activity
2005-07-01 Added XREF EC:2.5.1.60
2005-07-01 Deleted XREF EC:2.5.1.-
2005-07-01 Added SYNONYM GGTase-II activity
2005-07-01 Added SYNONYM GGTaseII activity
2005-07-01 Added SYNONYM Rab geranylgeranyltransferase activity
2005-07-01 Added SYNONYM RabGGTase activity
2005-07-01 Added SYNONYM geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
2005-07-01 Added SYNONYM protein geranylgeranyltransferase type II activity
2005-06-29 Updated DEFINITION Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.
2004-09-09 Updated TERM Rab-protein geranylgeranyltransferase activity
2004-09-08 Added DEFINITION Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group to a protein via thioether linkages to a cysteine residue within a CC or CXC recognition motif at or near the C terminus, such as that found in the small GTPase Rab.
2003-03-19 Updated TERM RAB-protein geranylgeranyltransferase activity
2002-02-06 Updated TERM RAB-protein geranylgeranyltransferase
2001-04-03 Updated TERM RAB-protein geranylgeranyltransferase
2001-03-30 Added XREF EC:2.5.1.-
2001-03-30 Added TERM RAB-protein geranylgeranyltransferase

Term

Timestamp Action Category Detail
2009-05-21 Updated TERM Rab geranylgeranyltransferase activity
2004-09-09 Updated TERM Rab-protein geranylgeranyltransferase activity
2003-03-19 Updated TERM RAB-protein geranylgeranyltransferase activity
2002-02-06 Updated TERM RAB-protein geranylgeranyltransferase
2001-04-03 Updated TERM RAB-protein geranylgeranyltransferase
2001-03-30 Added TERM RAB-protein geranylgeranyltransferase

Definition/synonyms

Timestamp Action Category Detail
2009-05-21 Deleted SYNONYM Rab geranylgeranyltransferase activity
2009-05-21 Added SYNONYM Rab-protein geranylgeranyltransferase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.
2007-09-06 Added SYNONYM type II protein geranyl-geranyltransferase activity
2007-08-09 Added SYNONYM RabGGTase activity
2007-08-09 Added SYNONYM geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
2007-08-09 Added SYNONYM protein geranylgeranyltransferase type II activity
2007-08-09 Added SYNONYM GGTase-II activity
2007-08-09 Added SYNONYM GGTaseII activity
2007-08-09 Added SYNONYM Rab geranylgeranyltransferase activity
2007-08-09 Deleted SYNONYM GGTase-II activity
2007-08-09 Deleted SYNONYM GGTaseII activity
2007-08-09 Deleted SYNONYM Rab geranylgeranyltransferase activity
2007-08-09 Deleted SYNONYM RabGGTase activity
2007-08-09 Deleted SYNONYM geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
2007-08-09 Deleted SYNONYM protein geranylgeranyltransferase type II activity
2005-07-01 Added SYNONYM GGTase-II activity
2005-07-01 Added SYNONYM GGTaseII activity
2005-07-01 Added SYNONYM Rab geranylgeranyltransferase activity
2005-07-01 Added SYNONYM RabGGTase activity
2005-07-01 Added SYNONYM geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
2005-07-01 Added SYNONYM protein geranylgeranyltransferase type II activity
2005-06-29 Updated DEFINITION Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.
2004-09-08 Added DEFINITION Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group to a protein via thioether linkages to a cysteine residue within a CC or CXC recognition motif at or near the C terminus, such as that found in the small GTPase Rab.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0004661 (protein geranylgeranyltransferase activity)

Cross-references

Timestamp Action Category Detail
2009-06-11 Deleted XREF MetaCyc:NULL
2009-05-21 Added XREF MetaCyc:RXN-3701
2009-05-21 Added XREF MetaCyc:NULL
2009-05-21 Added XREF MetaCyc:2.5.1.60-RXN
2005-07-01 Added XREF EC:2.5.1.60
2005-07-01 Deleted XREF EC:2.5.1.-
2001-03-30 Added XREF EC:2.5.1.-
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
13ms