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GO:0004663 Rab geranylgeranyltransferase activityCatalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.
Term Information
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| Type | Synonym |
| exact | geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity |
| exact | Rab-protein geranylgeranyltransferase activity |
| exact | GGTase-II activity |
| exact | GGTaseII activity |
| exact | protein geranylgeranyltransferase type II activity |
| exact | type II protein geranyl-geranyltransferase activity |
| exact | RabGGTase activity |
| Database | ID |
| MetaCyc | RXN-3701 |
| MetaCyc | 2.5.1.60-RXN |
| EC | 2.5.1.60 |
| INTERPRO | IPR009087 |
| INTERPRO | IPR001738 |
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0003674 molecular_function | |||||||
![]() | GO:0003824 catalytic activity | ||||||
![]() | ![]() | GO:0016740 transferase activity | |||||
![]() | ![]() | ![]() | GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups | ||||
![]() | ![]() | ![]() | ![]() | GO:0004659 prenyltransferase activity | |||
![]() | ![]() | ![]() | ![]() | ![]() | GO:0008318 protein prenyltransferase activity | ||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0004661 protein geranylgeranyltransferase activity | |
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0004663 Rab geranylgeranyltransferase activity |
| Code | Relationship |
![]() | part of |
![]() | is a |
![]() | regulates |
![]() | +ve regulates |
![]() | -ve regulates |
| Hostname | tomcat-7.ebi.ac.uk |
| Uptime | 16:38 12/10/2009 |
| Data version | 2009-11-22-04-02-35 |