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GO:0004662 CAAX-protein geranylgeranyltransferase activity

Term Information

ID GO:0004662
Name CAAX-protein geranylgeranyltransferase activity
Ontology Molecular Function
Definition Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
PMID:8621375
GONUTS GO:0004662 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact GGTase-I activity
exact GGTaseI activity
related protein geranylgeranyltransferase type I
exact geranylgeranyltransferase type I activity
exact type I protein geranyl-geranyltransferase activity
exact geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 2.5.1.59
MetaCyc 2.5.1.60-RXN
MetaCyc RXN-3701

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004662:
Relationship To GO:0004662 Child Term Child Term Name
Capable of GO:0005953 CAAX-protein geranylgeranyltransferase complex

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004662. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004662 based on the entire annotation set Co-occurrence statistics for GO:0004662 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2009-05-21 Added XREF MetaCyc:RXN-3701
2009-05-21 Added XREF MetaCyc:2.5.1.60-RXN
2008-05-13 Added DEFINITION Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
2008-04-01 Updated RELATION is a GO:0004661 (protein geranylgeranyltransferase activity)
2007-11-08 Added SYNONYM protein geranylgeranyltransferase type I
2007-09-06 Added SYNONYM type I protein geranyl-geranyltransferase activity
2007-08-09 Added SYNONYM GGTase-I activity
2007-08-09 Added SYNONYM GGTaseI activity
2007-08-09 Added SYNONYM geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
2007-08-09 Added SYNONYM geranylgeranyltransferase type I activity
2007-08-09 Deleted SYNONYM GGTase-I activity
2007-08-09 Deleted SYNONYM GGTaseI activity
2007-08-09 Deleted SYNONYM geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
2007-08-09 Deleted SYNONYM geranylgeranyltransferase type I activity
2005-07-01 Added SYNONYM GGTase-I activity
2005-07-01 Added SYNONYM GGTaseI activity
2005-07-01 Added SYNONYM geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
2005-07-01 Added XREF EC:2.5.1.59
2005-07-01 Deleted XREF EC:2.5.1.-
2005-07-01 Added SYNONYM geranylgeranyltransferase type I activity
2005-06-29 Updated DEFINITION Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
2004-09-08 Added DEFINITION Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group to a protein via thioether linkages to a cysteine residue within a CAAX recognition motif at or near the C terminus.
2003-03-19 Updated TERM CAAX-protein geranylgeranyltransferase activity
2002-02-06 Updated TERM CAAX-protein geranylgeranyltransferase
2001-04-03 Updated TERM CAAX-protein geranylgeranyltransferase
2001-03-30 Added XREF EC:2.5.1.-
2001-03-30 Added TERM CAAX-protein geranylgeranyltransferase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM CAAX-protein geranylgeranyltransferase activity
2002-02-06 Updated TERM CAAX-protein geranylgeranyltransferase
2001-04-03 Updated TERM CAAX-protein geranylgeranyltransferase
2001-03-30 Added TERM CAAX-protein geranylgeranyltransferase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
2007-11-08 Added SYNONYM protein geranylgeranyltransferase type I
2007-09-06 Added SYNONYM type I protein geranyl-geranyltransferase activity
2007-08-09 Added SYNONYM GGTase-I activity
2007-08-09 Added SYNONYM GGTaseI activity
2007-08-09 Added SYNONYM geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
2007-08-09 Added SYNONYM geranylgeranyltransferase type I activity
2007-08-09 Deleted SYNONYM GGTase-I activity
2007-08-09 Deleted SYNONYM GGTaseI activity
2007-08-09 Deleted SYNONYM geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
2007-08-09 Deleted SYNONYM geranylgeranyltransferase type I activity
2005-07-01 Added SYNONYM GGTase-I activity
2005-07-01 Added SYNONYM GGTaseI activity
2005-07-01 Added SYNONYM geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
2005-07-01 Added SYNONYM geranylgeranyltransferase type I activity
2005-06-29 Updated DEFINITION Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
2004-09-08 Added DEFINITION Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group to a protein via thioether linkages to a cysteine residue within a CAAX recognition motif at or near the C terminus.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0004661 (protein geranylgeranyltransferase activity)

Cross-references

Timestamp Action Category Detail
2009-05-21 Added XREF MetaCyc:RXN-3701
2009-05-21 Added XREF MetaCyc:2.5.1.60-RXN
2005-07-01 Added XREF EC:2.5.1.59
2005-07-01 Deleted XREF EC:2.5.1.-
2001-03-30 Added XREF EC:2.5.1.-
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