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GO:0004662 CAAX-protein geranylgeranyltransferase activityCatalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
Term Information
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| Type | Synonym |
| exact | type I protein geranyl-geranyltransferase activity |
| related | protein geranylgeranyltransferase type I |
| exact | GGTase-I activity |
| exact | GGTaseI activity |
| exact | geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity |
| exact | geranylgeranyltransferase type I activity |
| Database | ID |
| EC | 2.5.1.59 |
| MetaCyc | 2.5.1.60-RXN |
| MetaCyc | RXN-3701 |
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0003674 molecular_function | |||||||
![]() | GO:0003824 catalytic activity | ||||||
![]() | ![]() | GO:0016740 transferase activity | |||||
![]() | ![]() | ![]() | GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups | ||||
![]() | ![]() | ![]() | ![]() | GO:0004659 prenyltransferase activity | |||
![]() | ![]() | ![]() | ![]() | ![]() | GO:0008318 protein prenyltransferase activity | ||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0004661 protein geranylgeranyltransferase activity | |
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0004662 CAAX-protein geranylgeranyltransferase activity |
| Code | Relationship |
![]() | part of |
![]() | is a |
![]() | regulates |
![]() | +ve regulates |
![]() | -ve regulates |
| Hostname | tomcat-7.ebi.ac.uk |
| Uptime | 16:38 12/10/2009 |
| Data version | 2009-11-22-04-02-35 |