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GO:0004660 protein farnesyltransferase activity

Term Information

ID GO:0004660
Name protein farnesyltransferase activity
Ontology Molecular Function
Definition Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
PMID:8621375
Comment The catalyzed reaction transfers a farnesyl group from farnesyl diphosphate to a target protein. There is no relationship between this activity and farnesyltransferase activity, GO:0004311, where the catalyzed reaction forms (free) geranylgeranyl diphosphate.
Secondary IDs GO:0018223
GONUTS GO:0004660 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact protein-cysteine farnesyltransferase activity
exact farnesyl-diphosphate:protein-cysteine farnesyltransferase activity
narrow CAAX farnesyltransferase activity
exact FTase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 2.5.1.58
MetaCyc 2.5.1.58-RXN

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004660:
Relationship To GO:0004660 Child Term Child Term Name
Capable of GO:0005965 protein farnesyltransferase complex

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004660. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004660 based on the entire annotation set Co-occurrence statistics for GO:0004660 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2009-05-21 Added XREF MetaCyc:2.5.1.58-RXN
2008-05-13 Added DEFINITION Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
2008-04-01 Updated RELATION is a GO:0008318 (protein prenyltransferase activity)
2007-11-08 Added SYNONYM farnesyl-diphosphate:protein-cysteine farnesyltransferase activity
2007-09-06 Added SYNONYM CAAX farnesyltransferase activity
2007-09-06 Added SYNONYM FTase activity
2007-08-09 Added SYNONYM protein-cysteine farnesyltransferase activity
2007-08-09 Deleted SYNONYM protein-cysteine farnesyltransferase activity
2005-08-29 Added XREF EC:2.5.1.58
2005-08-29 Deleted XREF EC:2.5.1.-
2005-08-27 Updated DEFINITION Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
2004-09-10 Added SECONDARY GO:0018223 (protein-cysteine farnesyltransferase activity)
2004-09-10 Added SYNONYM protein-cysteine farnesyltransferase activity
2004-09-08 Added DEFINITION Catalysis of the covalent addition of a farnesyl (15-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.
2003-03-19 Updated TERM protein farnesyltransferase activity
2002-02-06 Updated TERM protein farnesyltransferase
2001-04-03 Updated TERM protein farnesyltransferase
2001-03-30 Added XREF EC:2.5.1.-
2001-03-30 Added TERM protein farnesyltransferase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM protein farnesyltransferase activity
2002-02-06 Updated TERM protein farnesyltransferase
2001-04-03 Updated TERM protein farnesyltransferase
2001-03-30 Added TERM protein farnesyltransferase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
2007-11-08 Added SYNONYM farnesyl-diphosphate:protein-cysteine farnesyltransferase activity
2007-09-06 Added SYNONYM CAAX farnesyltransferase activity
2007-09-06 Added SYNONYM FTase activity
2007-08-09 Added SYNONYM protein-cysteine farnesyltransferase activity
2007-08-09 Deleted SYNONYM protein-cysteine farnesyltransferase activity
2005-08-27 Updated DEFINITION Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
2004-09-10 Added SYNONYM protein-cysteine farnesyltransferase activity
2004-09-08 Added DEFINITION Catalysis of the covalent addition of a farnesyl (15-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0008318 (protein prenyltransferase activity)

Cross-references

Timestamp Action Category Detail
2009-05-21 Added XREF MetaCyc:2.5.1.58-RXN
2005-08-29 Added XREF EC:2.5.1.58
2005-08-29 Deleted XREF EC:2.5.1.-
2001-03-30 Added XREF EC:2.5.1.-

Other

Timestamp Action Category Detail
2004-09-10 Added SECONDARY GO:0018223 (protein-cysteine farnesyltransferase activity)
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